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Romagnoli, Romeo,Baraldi, Pier Giovanni,Lopez-Cara, Carlota,Cruz-Lopez, Olga,Carrion, Maria Dora,Kimatrai Salvador, Maria,Bermejo, Jaime,Est?vez, Sara,Est?vez, Francisco,Balzarini, Jan,Brancale, Andre Wiley-VCH 2011 CHEMMEDCHEM Vol.6 No.10
<P>Induction of apoptosis is a promising strategy that could lead to the discovery of new molecules active in cancer chemotherapy. This property is generally observed when cells are treated with agents that target microtubules, dynamic structures that play a crucial role in cell division. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. A new class of inhibitors of tubulin polymerization based on the 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan molecular skeleton, with the amino group placed at different positions on the benzene ring, were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell-cycle effects. The methoxy substitution pattern on the benzene portion of the benzo[b]furan moiety played an important role in affecting antiproliferative activity. In the series of 5-amino derivatives, the greatest inhibition of cell growth occurred if the methoxy substituent is placed at the C6 position, whereas C7 substitution decreases potency. The most promising compound in this series is 2-(3',4',5'-trimethoxybenzoyl)-3-methyl-5-amino-6-methoxybenzo[b]furan (3 h), which inhibits cancer cell growth at nanomolar concentrations (IC(50) =16-24 nM), and interacts strongly with tubulin by binding to the colchicine site. Sub-G(1) apoptotic cells in cultures of HL-60 and U937 cells were observed by flow cytometric analysis after treatment with 3 h in a concentration-dependent manner. We also show that compound 3 h induces apoptosis by activation of caspase-3, -8, and -9, and this is associated with cytochrome c release from mitochondria. The introduction of an α-bromoacryloyl group increased antiproliferative activity with respect to the parent amino derivatives.</P>
Marco Romagnoli 국립민속박물관 2019 International Journal of Intangible Heritage Vol.14 No.-
The 2003 UNESCO Convention for the Safeguarding ofthe Intangible Cultural Heritage paved the way as thefirst international and binding instrument to safeguard‘intangible cultural heritage’. ICH is a relatively newlydefinedconcept by UNESCO, differentiated from thecategory of UNESCO World Heritage related to the 1972Convention. This shift of paradigm – from tangible tointangible, from ‘cultural objects’ to ‘cultural processes’,and from protecting to safeguarding – constitutes arenewal of the definition and management of immaterialmanifestations as well as their inscription on theUNESCO ICH Lists. In 2010, the Traditional MexicanCuisine, the Mediterranean diet and the GastronomicMeal of the French were inscribed on the RepresentativeList of the Intangible Cultural Heritage of Humanity. These inscriptions represented a step forward inUNESCO’s recognition of new heritage categories and,more specifically, the consideration of gastronomy withregard to its symbolic, identity and ritual role in societies. From 2010, more gastronomic elements made it to theList. Nevertheless, academic research on food heritagemainly analysed case studies about cuisine and foodinstead of providing theoretical perspectives, and theeffects of food heritagisation on the UNESCO List arefar from having been thoroughly studied and evaluatedthrough fieldwork. The aim of this paper is to explorethe ways in which heritage is constructed 1) starting bydefining cultural heritage, Intangible Cultural Heritageand gastronomic heritages, 2) continuing to challengethe actual feasibility of heritagising gastronomy and thesocial practices associated therewith, via UNESCO, and 3)ending with some reflections on the reasons for the greatinterest in inscribing food heritage with UNESCO.
An atypical case of respiratory actinobacillosis in a cow
Peli Angelo,Spadari Alessandro,Romagnoli Noemi,Scarpa Filippo,Pietra Marco,Bettini Giuliano 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.3
A not pregnant 4-year-old Jersey cow was presented with the sudden appearance of respiratory noise, nasal discharge and moderate respiratory difficulty. Upon physical examination a snoring-like noise, extended head and neck position, exaggerated abdominal effort, bilateral nasal discharge and left prescapular lymph node enlargement were noted. Sub-occlusion of the initial portion of the respiratory tract was suspected. Radiographic and endoscopic examinations revealed a pedunculate mass on the dorsal aspect of the rhinopharynx, which was removed with endoscopically assisted electrosurgery. Histologic examination revealed a chronic pyogranulomatous inflammation with eosinophilic club-like bodies surrounding small colonies of rod-shaped bacteria. Results of histochemical staining were consistent with Actinobacillus-like bacteria and a diagnosis of respiratory actinobacillosis was reached. Surgery and antibiotic therapy were resolutive, as demonstated by an endoscopic check at the second month after surgery, even without the association of the traditional iodine cure, which is regarded as the treatment of choice for actinobacillosis.
Balderramo Domingo C.,Romagnoli Pablo Alberto,Granlund Atle van Beelen,Catalan-Serra Ignacio 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.4
There is growing evidence of the role of fungal microbiota in the pathogenesis of inflammatory bowel disease (IBD). Fungi can exert direct pro-inflammatory effects or modify the bacterial composition via interkingdom interactions. Although several studies have demonstrated alterations in the fecal fungal microbiota composition in IBD, there is a wide variation in the mycobiome in different populations, with no definite pattern that can define the mycobiome in IBD having yet been identified. Recent work has suggested that characterizing the fecal fungal composition may influence therapeutic decisions and help to predict outcomes in a subset of IBD patients. In this study, we review the current literature on the emerging role of the fecal mycobiome as a potential tool for precision medicine in IBD.
Clinical findings, rhinoscopy and histological evaluation of 54 dogs with chronic nasal disease
Marco Pietra,Flavio Pasquali,Noemi Romagnoli,Giuliano Bettini,Alessandro Spadari,Giuseppe Spinella 대한수의학회 2010 Journal of Veterinary Science Vol.11 No.3
Nasal diseases are very common in dogs and rhinoscopy is often required for a definitive diagnosis. Rhinoscopy, while superficial in nature, can guide the clinician to the final diagnosis. In this study, rhinoscopy was performed on 54 dogs with symptoms of chronic nasopharyngeal disease. The endoscopic diagnosis of neoplasia or chronic nasal inflammation was validated with histological examination of pathological samples, in order to evaluate the degree of concordance between endoscopic findings and histological diagnosis. The agreement between endoscopy and histology was tested by application of Cohen’s kappa coefficient. We conclude that correlation between endoscopic results and histological diagnosis, expressed by a Cohen’s kappa coefficient of 0.73,is only possible with a constant cooperation between the clinician and the pathologist.
Interventional Radiological Treatment of Renal Transplant Complications: A Pictorial Review
Roberto Iezzi,Michele Fabio la Torre,Marco Santoro,Roberta Dattesi,Massimiliano Nestola,Alessandro Posa,Jacopo Romagnoli,Franco Citterio,Lorenzo Bonomo 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.3
Renal transplantation is the treatment of choice for patients with chronic renal failure, which produces a dramatic improvement in the quality of life and survival rates, in comparison to long-term dialysis. Nowadays, new imaging modalities allow early diagnosis of complications, and thanks to the recent developments of interventional techniques, surgery may be avoided in most cases. Knowledge in the types of renal transplant complications is fundamental for a correct pre-operative planning. In this article, we described the most common or clinically relevant renal transplant complications and explained their interventional management.