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        Impact of scaling and root planing on C-reactive protein levels in gingival crevicular fluid and serum in chronic periodontitis patients with or without diabetes mellitus

        Mohan, Mahendra,Jhingran, Rajesh,Bains, Vivek Kumar,Gupta, Vivek,Madan, Rohit,Rizvi, Iram,Mani, Kanchan Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.4

        Purpose: The present study was conducted to evaluate the impact of scaling and root planing (SRP) on the C-reactive protein (CRP) levels of gingival crevicular fluid (GCF) and serum in chronic periodontitis patients with type 2 diabetes mellitus (T2DM-CP) or without type 2 diabetes mellitus (NDM-CP). Methods: Forty-eight human participants were divided into two groups: an experimental (T2DM-CP) group (group I, n=24) comprising chronic periodontitis patients with random blood sugar ${\geq}200mg/dL$ and type 2 diabetes mellitus, and control (NDM-CP) group (group II, n=24) of those with chronic periodontitis and random blood sugar <200 without T2DM for the study. All subjects underwent nonsurgical periodontal therapy (NSPT) including complete SRP and subgingival debridement. Periodontal health parameters, plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), GCF volume (GCF vol), GCF-CRP, random blood glucose (RBS), glycated hemoglobin, and systemic inflammatory markers, serum CRP, total leukocyte count (TLC), neutrophil count (Neutr) and lymphocyte count (Lymph), were evaluated at baseline, 1 month, and 3 months after SRP. Results: NSPT resulted in statistically significant improvement in periodontal health parameters (PI, GI, PPD, CAL, GCF vol), CRP levels in serum as well as GCF of both groups I and II. The mean improvement in periodontal health parameters (PI, GI, PPD, CAL, GCF vol), CRP levels in serum and GCF was greater in group I than group II after NSPT. There was nonsignificant increase in GCF-CRP, TLC, Lymph, and RBS, and a significant increase in Neutr and Serum CRP in group II at 1 month. The Serum CRP level of 20 out of 24 group II patients had also increased at 1 month. Conclusions: The CRP levels in both GCF and serum were higher in T2DM-CP patients than in NDM-CP patients. Although there was a significant improvement in both the groups, greater improvement was observed in both GCF and serum samples of T2DM-CP patients.

      • KCI등재

        Impact of scaling and root planing on C-reactive protein levels in gingival crevicular fluid and serum in chronic periodontitis patients with or without diabetes mellitus

        Mahendra Mohan,Rajesh Jhingran,Vivek Kumar Bains,Vivek Gupta,Rohit Madan,Iram Rizvi,Kanchan Mani 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.4

        Purpose: The present study was conducted to evaluate the impact of scaling and root planing (SRP) on the C-reactive protein (CRP) levels of gingival crevicular fluid (GCF) and serum in chronic periodontitis patients with type 2 diabetes mellitus (T2DM-CP) or without type 2 diabetes mellitus (NDM-CP). Methods: Forty-eight human participants were divided into two groups: an experimental (T2DM-CP) group (group I, n=24) comprising chronic periodontitis patients with random blood sugar ≥200 mg/dL and type 2 diabetes mellitus, and control (NDM-CP) group (group II, n=24) of those with chronic periodontitis and random blood sugar <200 without T2DM for the study. All subjects underwent nonsurgical periodontal therapy (NSPT) including complete SRP and subgingival debridement. Periodontal health parameters, plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), GCF volume (GCF vol), GCF-CRP, random blood glucose (RBS), glycated hemoglobin, and systemic inflammatory markers, serum CRP, total leukocyte count (TLC), neutrophil count (Neutr) and lymphocyte count (Lymph), were evaluated at baseline, 1 month, and 3 months after SRP. Results: NSPT resulted in statistically significant improvement in periodontal health parameters (PI, GI, PPD, CAL, GCF vol), CRP levels in serum as well as GCF of both groups I and II. The mean improvement in periodontal health parameters (PI, GI, PPD, CAL, GCF vol), CRP levels in serum and GCF was greater in group I than group II after NSPT. There was nonsignificant increase in GCF-CRP, TLC, Lymph, and RBS, and a significant increase in Neutr and Serum CRP in group II at 1 month. The Serum CRP level of 20 out of 24 group II patients had also increased at 1 month. Conclusions: The CRP levels in both GCF and serum were higher in T2DM-CP patients than in NDM-CP patients. Although there was a significant improvement in both the groups, greater improvement was observed in both GCF and serum samples of T2DM-CP patients.

      • KCI등재

        Rice straw (Oryza sativa L.) biomass conversion to furfural, 5-hydroxymethylfurfural, lignin and bio-char: A comprehensive solution

        Ajay Kumar,Arvind Singh Chauhan,Rohit Bains,Pralay Das 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-

        A sustainable, easy to operate, scalable, and chemically pre-treatments free method has been explored forrice straw (RS) biomass conversion to furfural, 5-hydroxymethylfurfural (5-HMF), lignin and bio-charproduction. Initially, the RS was dipped into liquid nitrogen in a thermos flask and grinded easily to finepowder for better handling of biomass under reaction conditions in a reactor. The process also reducesthe volume of biomass and enhances the surface area of RS biomass which was further analysed bySEM, TEM, IR, TGA and DSC, and further validated by its fruitful conversion to furfural, 5-HMF, ligninand bio-char synthesis in satisfied yields. The developed acidic process was performed at 130 C for 6hrs under a closed reaction system in reflux conditions. The ultra-performance liquid chromatography(UPLC) purity of furfural and 5-HMF was measured to >90% without additional purification technique. Moreover, the method was also examined in 250-gram scale and found to perform well.

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