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- 저자 : Robert Dunbar (검색결과 2 건)
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김부근,Robert Dunbar,김동선 한국지질과학협의회 2013 Geosciences Journal Vol.17 No.3
Sediment trap deployments in the eastern Bransfield Basin (west Antarctic) show seasonal and inter-annual variability in particle fluxes, with most of total annual flux at mid-depth occurring during a short period. High seasonality in particle flux may be associated with biological processes (the timing of phytoplankton blooms) and physical factor (sea-ice cover). Inter-annual variability of particle flux may also reflect inter-annual variation of sea-ice cover related to the biological processes. Most notable is that year-round high particle flux is observed in sediment traps moored near the seabed, which is not unexpected, emphasizing the contribution of supplementary transport of lithogenic particles particularly during the unproductive season. In this case, particles in relatively rapid vertical transit, such as aggregates and fecal pellets, are presumably mixed with laterally-transported particles. The relationship between d15N values and biogenic particle flux highlights the contribution of particles in lateral transit to the vertical setting particles downward to the near-bottom sediment trap. Mid-depth sediment trap shows clear seasonal d15N variability, whereas the near-bottom sediment trap shows no distinct seasonal trend, indicating the contamination of low d15N, fresh organic material by high d15N, regenerated and more refractory material resuspended from shallow continental margin. However, judging from the flux-weight d15N values between the mid-depth and near-bottom sediment traps, biogeochemical components contained in the horizontally delivered particles are not critical to prevent the surface-water condition preserved in those of downward sinking particles. Our results provide the convincing implications from the recovery of paleoclimatic information using sediment cores from the eastern Bransfield Basin (west Antarctic).
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Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study
Kim, S.,Kim, N.,Presson, Angela P.,Metzger, Mark E.,Bonifacino, Aylin C.,Sehl, M.,Chow, Samson A.,Crooks, Gay M.,Dunbar, Cynthia E.,An, D.,Donahue, Robert E.,Chen, Irvin S.Y. Cell Press 2014 Cell stem cell Vol.14 No.4
In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in repopulation characteristics. However, it is unclear whether similar properties apply in primates. Here, we examined this issue through tracking of thousands of hematopoietic stem and progenitor cells (HSPCs) in rhesus macaques for up to 12 years. Approximately half of the clones analyzed contributed to long-term repopulation (over 3-10 years), arising in sequential groups and likely representing self-renewing HSCs. The remainder contributed primarily for the first year. The long-lived clones could be further subdivided into functional groups contributing primarily to myeloid, lymphoid, or both myeloid and lymphoid lineages. Over time, the 4%-10% of clones with robust dual lineage contribution predominated in repopulation. HSPCs expressing a CCR5 shRNA transgene behaved similarly to controls. Our study therefore documents HSPC behavior in a clinically relevant model over a long time frame and provides a substantial system-level data set that is a reference point for future work.
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