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      저자 : Richard L. Beissinger (검색결과 2 건)
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      • SCIESCOPUSKCI등재

        Evaluation of Shear - Induced Particle Diffusivity in Red Cell Ghosts Suspensions

        Cha, Woo Nou,Beissinger, Richard L . 한국화학공학회 2001 Korean Journal of Chemical Engineering Vol.18 No.4

        The shear-induced particle diffusivity in the red blood cell suspensions was evaluated based on the flow model and experimental results in a rectangular flow chamber. The effective diffusivity (D_e) of solute in the particle suspensions is equal to the stationary diffusivity (D_s) of the solute plus the shear-induced particle diffusivity (D_p). The effective diffusivity (D_e) of bovine senun albumin (BSA) in the red blood cell (RBC) ghost suspensions was determined under diffusion-limited conditions using a total internal reflection fluorescence (TIRF) method as a function of suspended RBC ghost volume fractions (0.05-0.7) and shear rates (200-1,000 s^(-1)). The stationary diffusivity (D_s) of BSA in RBC ghost suspensions was calculated by Meredith and Tobias model. Therefore the shear-induced particle diffusivity undergoing laminar shear flow can be evaluated. The shear-induced RBC ghost difiusivity was ranged from 0.35×10^(-7) to 21.2×10^(-7) cm²/s and it increased with increasing shear rate. Also the shear-induced RBC ghost diffusivity increased as a particle volume fraction increased as well, up to a particle volume fraction of 0.45. However, for RBC ghost volume fractions above 0.45, the shear-induced particle diffusivity decreased with increasing particle volume fraction. The shear-induced particle diffusivity in RBC ghost suspensions is a function of a particle Peclet number (or shear rate) and particle volume fractions. The dimensionless particle diiffusivity (D_p/a²γ) was investigated as a function of particle volume fraction and these results are in good agreement with the literature values.

      • KCI등재

        플라즈마 단백질의 고스트 적혈구 흡착 특성

        김동욱(DongUk Kim),차운오(WoonOu Cha),Richard L. Beissinger 한국생물공학회 1996 KSBB Journal Vol.11 No.6

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