과민성 장증후군 환자에서 베타 아드레날린 수용체 기능의 활성도와 불안 수준

강은호,이풍렬,이준행,김현서,이종철,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.1

의복 쇼핑 성향의 개념 규명을 위한 문헌적 연구

김세희,이은영 한국의류학회 2004 한국의류학회지 Vol.28 No.3,4

As the sphere of consumers' shopping behavior expands, the need to understand shopping orientation also increases. Yet, there has been few research that investigated the nature of clothing shopping orientation[CSO]. Thus, more research that accounts for CSO is needed. The purpose of this study is to determine the concept of CSO. In order to study CSO, documentary research was conducted. The results of this study were as follows: In order to identify the concept of CSO, the concept of general shopping orientation was determined first the concept of CSO was determined. Through investigating the relationship between clothing lifestyle and , and comparing the general shopping orientation and CSO, the concept of CSO was ultimately determined as a clothing shopping specific life style, that is, a patternized clothing shopping aspect integrating consumer's activity, interest, and opinion relating to clothing shopping. It comprehends both behavioral and psychological aspects appearing while the clothing shopping, and before and after the clothing shopping. The results of this study would be useful to reduce the confusion between the concept of CSO and other similar concepts, and to guide valid research on CSO.

소규모사업장 보건관리기술지원사업 지원여부에 따른 사업장내 의사소통 비교

정최경희,박혜숙,김정연,이경용,현성민,오지영,김수근,김현주,하은희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

목적: 소규모사업장 보건관리기술지원사업 지원여부에 따라 사업장내 위험의사소통채널이 마련되었는지와 이 채널이 기능을 하는지, 그리고 의사소통채널마련과 사업장내 위험의사소통 활성화의 기본적이고 중요한 배경이 되는 사업주의 산업보건에 대한 관심이 차이가 있는지에 대해 살펴보고자 하였다. 방법: 서울, 안산, 대전, 광주, 포항 지역에서 보건관리기술지원사업을 받은 사업장과 받지 않은 사업장을 대상으로 비례층화무작위표본추출법을 사용하여 추출한 후 1991년 12월 6일부터 10일간 우편설문조사를 실시하였다. 설문대상은 각 사업장의 남녀 각 1명, 보건업무담당자, 사업주였으며, 설문내용은 사업장 및 응답자의 일반적 특성 및 사업장내 위험의사소통이었다. 설문에 응답이 온 463개 사업장의 자료를 자료처리하여 총 228개 사업장(단해년도지원 사업장 189개, 연속2년지원 사업장 13개, 비지원사업장 26개)을 대상으로 분석하였다. 결과: 사업장내 의사소통에 대한 단변량분석에서는 보건업무 담당자의 선정여부만이 통계적으로 유의한 차이가 있었다. 소규모사업장 보건관리기술지원사업을 지원받지 않은 사업장과 지원받은 사업장의 사업장내 위험의사소통을 비교하기 위한 로지스틱회귀분석 결과, 모든 항목에서 통계적으로는 유의한 차이를 보여주지 않았다. 그러나 사업주의 관심(OR ; 1.63, 95% CI ; 0.38~7.01)과 보건업무담당자의 선정(OR ; 3.67, 95% CI ; 1.00~13.44) 및 결정권한(OR ; 1.48, 95% CI ; 0.25~8.91), 사업주의 산업보건문제 소통(OR ; 3.07, 95% CI ; 0.81~11.71), 보건업무담당자의 정보요청경험(OR; 4.48, 95% CI ; 0.97~20.57)에서는 지원받지 않은 사업장에 비해 지원받은 사업장에서 교차비가 증가하는 양상을 보여주었다. 반면 노동자의 산업보건문제 소통가능성여부는 오히려 교차비가 0.53(95% CI ; 0.11~2.44)로 감소하는 경향을 보여주었다. 결론: 소규모사업장 보건관리기술지원사업을 의사소통의 측면에서 평가해보면, 사업주나 보건업무담당자에게는 다소 효과가 있었지만 노동자가 지속적으로 참여할 수 있도록 의사소통문화를 바꾸어내는 데에는 한계가 있었다. 개선을 위해서는 노동자 중심의 접근 프로그램의 개발 및 시행이 시급하다 할 수 있다. Objectives :This study was to evaluate the effectiveness of the government-funded subsidized occupational health program for small-scale enterprises(GSOHP_SSE) by occupational health com-munication in workplace. Methods : We sampled the 1,835 enterprises of study by proportional stratified random sampling among industries of supported and not supported by GSOHP_SSE in Seoul, Ansan, Daejeon, Kwang-joo and Pohang. Information on the general characteristics of enterprises and respondants and occupational health communication in the workplace was collected on self-reported questionnaires by post-survey between December 6 and 15 in 2001. We received answers from 463 enterprises and analyzed 228 enterprises through data-cleaning by logistic regression to evaluate effectiveness of GSOHP-SSE about occupational health communication in the workplace. Results : By multiple logistic regression analysis, GSOHP_SSE turned out not to be statistically significant factor in all dependent variables about occupational health communication in the work-place. The concern of owner(odds ratio (below OR) ; 1.63, 95% confidence interval(below 95% CI) ; 0.38-7.01), formation(OR ; 3.67, 95% CI ; 1.00-13.44) and empowerment(OR ; 1.48, 95% CI ; 0.25-8.91) of health manager, request about occupational health problem of health manager(OR ;4.48, 95% CI ; 0.97-20.57) and occupational health communication of owner (OR ; 3.07, 95% CI ; 0.81-11.71) had the trend increasing OR in the industries supported GS-OHP_SSE relative to the industries not supported. But in recognition of possibility on occupational health communication of laborers, OR of GSOHP_SSE was decreased in 0.53(95% CI ; 0.11-2.44). Conclusions: This study found that the GSOHP_SSE was some effective to the side of employer and health manager, but had a limitation about change of communication culture useful to the laborers. We suggested the laborer-centered health training programs or the empowerment-based health training programs for effective occupational health management in the workplace.

Buffer/CoFe/Cu/Co 샌드위치 박막의 자기저항 특성

김희중,김미양,오미영,이장로,송은영,김경민 숙명여자대학교 자연과학연구소 1996 자연과학논문집 Vol.- No.7

DC magnetron sputtering방법으로 Corning glass 기판위에 버퍼층을 Fe와 ??로 바꾸어가면서 보자력이 다른 ??와 Co를 이용하여 buffer/CoFe(35Å)/Cu(tÅ)/Cu(35Å)의 형태로 샌드위치 박막을 제작하고 자기저항비의 버퍼층 두께 및 비자성층 Cu층 두께, 자성층 두께 의존성을 조사하였다. 자기저항비와 포화 자기장(??)은 버퍼층의 두께가 두꺼워짐에 따라 증대하다가 극대치 3%를 보인 후 완만하게 감소하였다. NiFe, Fe버퍼층을 갖는 시료를 비교한 경우, 각각 CoFe층과 Co층 사이의 결합 자기장(??)은 큰 차이가 없었으나 NiFe버퍼층을 갖는 시료가 minor자기저항 곡선의 반가폭 ??는 감소하고 자기저항(MR) slope와 관련된 field senditivity(%/Oe)는 향상되었다. Buffer(tÅ)/CoFe(35Å)/Cu(50Å)/Co(35Å) sandwiches prepared by dc magnetron sputtering on a corning glass substrate using ?? and Co possess different coercivities. Dependence of magnetoresistance on the type and thickness of buffer layer, thickness of Cu and thickness of magnetic layer in buffer/CoFe/Cu/Co sandwiches were investigated. Magnetoresistance ratio and saturation field ?? increased as the thickness of buffer layer becomes thicker, then decreased smoothly after maximum value. Improved field sensitivity was realized by the use of ?? buffer layer.

버퍼층 및 열처리 효과가 CoFe/Cu 다층박막의 자기저항에 미치는 영향

오미영,송은영,이장로,김희중,김경민,김미양 숙명여자대학교 자연과학연구소 1996 자연과학논문집 Vol.- No.7

DC magnetron sputtering방법에 의해 Corning glass기판 위에 ?? 형태로 다층박막을 제작하여 버퍼층 종류(Fe, Cu, Cr, Ta)와 두께, 비자성층인 Cu두께 변화에 관한 자기저항비의존성을 조사하였다. 또한 이들 시료에 대하여 열처리를 행한 후 열처리가 이 시료의 구조, 자기적 성질 및 자기저항에 미치는 영향을 조사하였다. Fe버퍼층의 두께가 60Å일 때 극대 자기저항비가 14%인 자기저항이 관찰되었고 Fe버퍼층과 Cr버퍼층을 갖는 시료를 비교한 경우 자기저항비는 그다지 차이가 없으나 Fe버퍼층이 있는 경우에 더 큰 포화자기장 및 자기 이력현상을 나타내었다. 250℃까지의 시료에 대한 열처리는 다층박막의 주기성을 유지한채 더 큰 결정립을 갖게 하여 자기저항비는 증가하였으나 그 이상의 온도에서는 계면 혼합 및 계면 확산에 의한 감소를 나타내었다. Giant magnetoresistance (GMR) and magnetic properties of CoFe/Cu multilayers prepared by dcmagnetron sputtering has been studied. We investigated the effect of Fe buffer layer thickness, different buffer layers, and annealing condition on GMR. For the 60Å Fe buffer layer thickness, maximum MR ratio 14% was found. When we have used different buffer layers, multilayers with Cr and Fe buffer show similar GMR magnitude, but multilayers with an Fe buffer have much higher saturation fields and hysteresis. The study of the dependence of the MR behaviors on annealing temperature, the MR ratio was increased to 250℃, but reduced at the temperature higher than 300℃ because of the interfacial diffuse.

양측성 관상동정맥루 1예

최용원,오석규,이재훈,이상재,권경희,최은경,김남호,정진원 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

저자들은 호흡곤란, 흉부불쾌감, 심계항진 등을 주소로 내원한 환자에서 경흉부 및 경식도 심초음파 검사상 주폐동맥에서 이완기에 전행하는 지속적인 혈류의 흐름을 관찰하고, 관상동맥 조영술을 통해 좌전하행지 중간부위와 우관상동맥 근위부에서 각각 기시하여 공통경로를 이루면서 주폐동맥으로 유입되는 양측성 관상동정맥루를 보이는 드문 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. A coronary arteriovenous fistula is infrequently encountered vascular communication between a coronary artery and a cardiac chamber, a great artery or the vena cava. It is the most common congenital anomaly that can affect coronary perfusion. Bilateral involvement of coronary fistula constitutes an uncommon subgroup of coronary arteriovenous fistulas. A 69 year-old female patient presented with chest discomfort, palpitation, and dyspnea. In the echocardiography, doppler color flow imaging visualized abnormal flow signals with mosaic appearance in the main pulmonary artery during diastolic phase. Coronary angiography revealed arteriovenous fistula arising from the left anterior descending artery and the right coronary artery. Both coronary arteriovenous fistulas drained into the main pulmonary artery. We report a case of bilateral coronary arteriovenous fistula that was confirmed by echocariography and coronary angiography.

The association of Pro12Ala polymorphism of peroxisomeproliferator-activated receptor-γ gene with serumosteoprotegerin levels in healthy Korean women

Eun-Jung Rhee, Ki-Won Oh,Eun-Joo Yun,Chan-Hee Jung,Cheol-Young Park,Won-Young Lee,Eun-Sook Oh,Ki-Hyun Baek,Moo-Il Kang,Sung-Woo Park,Sun-Woo Kim 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.6

Novel ATP8B1 Gene Mutations in a Child with Progressive Familial Intrahepatic Cholestasis Type 1

Eun Sang Rhee,Yu Bin Kim,Sunghee Lee,Seak Hee Oh,Beom Hee Lee,Kyung Mo Kim,Han-Wook Yoo 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.5

Progressive familial intrahepatic cholestasis (PFIC) is a group of severe genetic disorders, inherited in an autosomal recessive manner, causing cholestasis of hepatocellular origin, later progressing to biliary cirrhosis and liver failure. This is the first report of PFIC type 1 with novel compound heterozygous mutations in Korea. The patient was presented with intrahepatic cholestasis, a normal level of serum γ-glutamyl transferase, steatorrhea, and growth failure. Genetic testing of this patient revealed novel compound heterozygous mutations (p.Glu585Ter and p.Leu749Pro) in the ATP8B1 gene. After a liver transplantation at age 19 months, the patient developed severe post-transplant steatohepatitis.

ORiginal Article : Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms

( Eun Ran Kim ),( Mun Hee Yang ),( Yeun Jung Lim ),( Jin Hee Lee ),( Dong Kyung Chang ),( Young Ho Kim ),( Hee Jung Son ),( Jae J Kim ),( Jong Chul Rhee ),( Jin Yong Kim ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5

Background/Aims: Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas. Methods: We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile. Results: The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorec-tal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced patho-logic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal ad-enomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels. Conclusions: These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neo-plasms. (Gut Liver 2013;7:519-523)

The relationship between four single nucleotide polymorphisms in the promoter region of the osteoprotegerin gene and aortic calcification or coronary artery disease in Koreans

Rhee, Eun Jung,Oh, Ki Won,Jung, Chan Hee,Lee, Won Young,Oh, Eun Sook,Yun, Eun Joo,Baek, Ki Hyun,Kang, Moo Il,Kim, Sun Woo Blackwell Publishing Ltd 2006 Clinical endocrinology Vol.64 No.6

<P>Summary</P><P>Objective </P><P>Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the receptor activator of the NF-&kgr;B ligand (RANKL). OPG has been shown to be an important inhibitor of osteoclastogenesis and arterial calcification in animal models. OPG has been proposed as a link molecule between osteoporosis and arterial calcification, but the relationship between the OPG gene and the cardiovascular system in human populations is unclear. Thus, the aim of this study was to investigate the relationship between OPG gene polymorphisms and aortic calcification or coronary artery disease in Koreans.</P><P>Design and patients </P><P>Genotyping of four polymorphisms, A163G, G209A, T245G and T950C, in the promoter region of the OPG gene was performed in 251 healthy Korean women (mean age 51·3 ± 6·9 years) and in a second study population consisting of 100 patients who underwent coronary angiography (mean age 57·0 ± 11·9 years), by allelic discrimination using the 5′ nuclease polymerase chain reaction assay. Cardiovascular risk factors and serum OPG levels were measured and aortic calcification in thoracic and abdominal aorta was examined by simple radiological methods.</P><P>Results </P><P>In the first study population, the prevalence of aortic calcification increased significantly as the subjects grew older. The frequencies of mutant alleles were significantly higher in the subjects with aortic calcification compared with those without aortic calcification in G209A and T950C polymorphisms, although these significances were lost after adjustment for age. No significant relationship was found between OPG gene polymorphisms and serum OPG levels or cardiovascular risk factors. In the second study group, there were no associations between OPG promoter genotypes and aortic calcification, serum OPG levels, or coronary artery disease.</P><P>Conclusions </P><P>We observed that the four polymorphisms in the promoter region of the OPG gene were not associated with aortic calcification or coronary artery disease in Koreans. Further studies are needed to clarify this relationship.</P>