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Serum interleukin-1beta and tumor necrosis factor-alpha in febrile seizures: is there a link?
Mahyar, Abolfazl,Ayazi, Parviz,Orangpour, Reza,Daneshi-Kohan, Mohammad Mahdi,Sarokhani, Mohammad Reza,Javadi, Amir,Habibi, Morteza,Talebi-Bakhshayesh, Mousa The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.10
Purpose: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrile seizures. The present study was conducted to identify potential links between serum interleukin-1beta (IL-$1{\beta}$), tumor necrosis factor-alpha (TNF-${\alpha}$), and febrile seizures. Methods: Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type), and 46 controls with comparable age, sex, and severity of temperature were enrolled. Results: The median concentrations of serum IL-$1{\beta}$ in the simple, complex febrile seizure, and control groups were 0.05, 0.1, and 0.67 pg/mL, respectively (P=0.001). Moreover, the median concentrations of TNF-${\alpha}$ in the simple, complex febrile seizure, and control groups were 2.5, 1, and 61.5 pg/mL, respectively (P=0.001). Furthermore, there were significant differences between the case groups in serum IL-$1{\beta}$ and TNF-${\alpha}$ levels (P<0.05). Conclusion: Unlike previous studies, our study does not support the hypothesis that increased IL-$1{\beta}$ and TNF-${\alpha}$ production is involved in the pathogenesis of febrile seizures.
Serum interleukin-1beta and tumor necrosis factor-alpha in febrile seizures: is there a link?
Abolfazl Mahyar,Parviz Ayazi,Reza Orangpour,Mohammad Mahdi Daneshi-Kohan,Mohammad Reza Sarokhani,Amir Javadi,Mousa Talebi-Bakhshayesh 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.10
Purpose: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remainsunclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrileseizures. The present study was conducted to identify potential links between serum interleukin-1beta(IL-1β), tumor necrosis factor-alpha (TNF-α), and febrile seizures. Methods: Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type),and 46 controls with comparable age, sex, and severity of temperature were enrolled. Results: The median concentrations of serum IL-1β in the simple, complex febrile seizure, and controlgroups were 0.05, 0.1, and 0.67 pg/mL, respectively (P=0.001). Moreover, the median concentrationsof TNF-α in the simple, complex febrile seizure, and control groups were 2.5, 1, and 61.5 pg/mL,respectively (P=0.001). Furthermore, there were significant differences between the case groups inserum IL-1β and TNF-α levels (P<0.05). Conclusion: Unlike previous studies, our study does not support the hypothesis that increased IL-1βand TNF-α production is involved in the pathogenesis of febrile seizures.