Nutritional Efficiency in Antheraea mylitta D. during Food Deprivation

Rath, S.S.,Sinha, B.R.R.P.,Thangavelu, K. Korean Society of Sericultural Science 2004 International Journal of Industrial Entomology Vol.9 No.1

Nutrition plays an important role in maintaining the larval health, cocoon quality and reproductive potential in Antheraea mylitta D. Nutritional efficiency greatly influenced if food is not adequate and of quality. A. mylitta silkworms were subjected to food deprivation for the period of 0 hr to 12 hrs /day to assess its effect on various nutritional parameters and indices, and its manifestation at different levels. Food ingesta, digesta, gain in body weight declined significantly at each level of deprivation, so also food utilization efficiency like consumption index (CI), growth rate (GR), approximate digestibility (AD), and efficiency of conversion of ingested food (ECI). This stress leads to decline in mean daily food ingesta by 16.73% to 39.76% and digesta by 28.98% to 54.01 % following a significant reduction in average daily body weight gain (27.68% to 55.09%). Food deprivation a1so caused significant loss in the silk gland weight, cocoon and shell weight (14.37% to 53.69%), lowered the fecundity (35.86 % to 83.59%) and in number of eggs laid per gram body weight, but simultaneously the number of non-chorionated eggs increased significantly.

A Stable Organic Radical Delocalized on a Highly Twisted π System Formed Upon Palladium Metalation of a Möbius Aromatic Hexaphyrin

Rath, Harapriya,Tokuji, Sumito,Aratani, Naoki,Furukawa, Ko,Lim, Jong Min,Kim, Dongho,Shinokubo, Hiroshi,Osuka, Atsuhiro WILEY-VCH Verlag 2010 Angewandte Chemie Vol.122 No.8

<B>Graphic Abstract</B> <P>Ein neuer Dreh bei Porphyrinen: Die Metallierung von Möbius-aromatischem Hexakis(pentafluorphenyl)[28]hexaphyrin ergibt ein stabiles organisches Radikal, das über ein zweifach verdrehtes π-System delokalisiert ist. Der Zweiphotonenabsorptionsquerschnitt ist deutlich höher als bei nichtaromatischen expandierten Porphyrinen (Pd rosa, Cl grün, N blau; ohne Phenylringe). <img src='wiley_img/00448249-2010-122-8-ANGE200906017-content.gif' alt='wiley_img/00448249-2010-122-8-ANGE200906017-content'> </P>

In Silico Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein

Rath, Surya Narayan,Das, Debasrita,Konkimalla, V Badireenath,Pradhan, Sukanta Kumar Korea Genome Organization 2016 Genomics & informatics Vol.14 No.3

Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer. In silico study reveals, miRNAs namely, miR-106a, miR-21, and miR-29b-2 have a strong binding affinity towards PTEN, TGFBR2, and VEGFA genes, respectively, suggested as important factors in RNA silencing mechanism. Furthermore, interaction between AGO protein (PDB ID-3F73, chain A) with selected miRNAs and with miRNAs-mRNAs duplex were studied computationally to understand their binding at molecular level. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.

Active Control of Nonlinear Suspension System Using Modified Adaptive Supertwisting Controller

Rath, Jagat J.,Veluvolu, Kalyana C.,Defoort, Michael Hindawi Limited 2015 Discrete dynamics in nature and society Vol.2015 No.-

<P>The suspension system is faced with nonlinearities from the spring, damper, and external excitations from the road surface. The objective of any control action provided to the suspension is to improve ride comfort while ensuring road holding for the vehicle. In this work, a robust higher order sliding mode algorithm combining the merits of the modified supertwisting algorithm and the adaptive supertwisting algorithm has been proposed for the nonlinear active suspension system. The proposed controller is robust to linearly growing perturbations and bounded uncertainties. Simulations have been performed for different classes of road excitations and the results are presented.</P>

Output Feedback Active Suspension Control With Higher Order Terminal Sliding Mode

Rath, Jagat Jyoti,Defoort, Michael,Karimi, Hamid Reza,Veluvolu, Kalyana Chakravarthy Institute of Electrical and Electronics Engineers 2017 IEEE transactions on industrial electronics Vol. No.

<P>The control of an automotive suspension system using hydraulic actuators is a highly complex nonlinear control task dealing with system nonlinearities, external disturbances, and uncertainties. In this work, an output feedback active suspension control scheme is proposed to achieve a ride comfort while maintaining the road holding for the vehicle. To design the controller, the states of the nonlinear system are first estimated using a highgain observer where the suspension stroke is the only measurable output. The controller is then designed using a recursive derivative nonsingular higher order terminal sliding mode approach that avoids singularity. The practical stability for the closed-loop observer-controller pair is established. Simulation results for the quarter-wheel vehicle over various road conditions demonstrate the effectiveness of the proposed control in improving the suspension performance in both the time and frequency domains.</P>

Drug Target Identification and Elucidation of Natural Inhibitors for Bordetella petrii: An In Silico Study

Rath, Surya Narayan,Ray, Manisha,Pattnaik, Animesh,Pradhan, Sukanta Kumar Korea Genome Organization 2016 Genomics & informatics Vol.14 No.4

Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. PRJNA28135) from genome database of National Centre for Biotechnology information. In this regards, the inhibitory effect of nine natural compounds like ajoene (Allium sativum), allicin (A. sativum), cinnamaldehyde (Cinnamomum cassia), curcumin (Curcuma longa), gallotannin (active component of green tea and red wine), isoorientin (Anthopterus wardii), isovitexin (A. wardii), neral (Melissa officinalis), and vitexin (A. wardii) have been acknowledged with anti-bacterial properties and hence tested against identified drug target of B. petrii by implicating computational approach. The in silico studies revealed the hypothesis that lpxD could be a potential drug target and with recommendation of a strong inhibitory effect of selected natural compounds against infection caused due to B. petrii, would be further validated through in vitro experiments.

Characterization of novel Ba₂LnMoO₆ (Ln = Pr and Nd) double perovskite as the anode material for hydrocarbon-fueled solid oxide fuel cells

Rath, Manasa K.,Lee, Ki-Tae Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.737 No.-

<P><B>Abstract</B></P> <P>Ba<SUB>2</SUB>LnMoO<SUB>6</SUB> (Ln = Pr and Nd), with a double perovskite structure, has been investigated as an efficient anode material for solid oxide fuel cells (SOFCs) operating under methane fuel. Ba<SUB>2</SUB>LnMoO<SUB>6</SUB> (Ln = Pr and Nd) powders were successfully synthesized by a citric acid ethylene-diamine-tetraacetic acid (CA-EDTA) combustion technique. Ba<SUB>2</SUB>LnMoO<SUB>6</SUB> (Ln = Pr and Nd) was thermally and morphologically stable at high temperature and chemically compatible with the Gd<SUB>0.2</SUB>Ce<SUB>0.8</SUB>O<SUB>1.8</SUB> (GDC) electrolyte. The electrical conductivities of Ba<SUB>2</SUB>PrMoO<SUB>6</SUB> and Ba<SUB>2</SUB>NdMoO<SUB>6</SUB> were 348.5 and 146 Scm<SUP>−1</SUP> under humidified CH<SUB>4</SUB> at 800 °C, respectively. However, Ba<SUB>2</SUB>LnMoO<SUB>6</SUB> (Ln = Pr and Nd) exhibits better catalytic activity for the hydrogen oxidation reaction (HOR) than for the methane oxidation reaction (MOR); this is due to the presence of deposited carbon, which blocks the fuel path during the overall methane oxidation process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ba<SUB>2</SUB>LnMoO<SUB>6</SUB> (Ln = Pr and Nd) reduce in 5%H<SUB>2</SUB>/Ar has cubic double perovskite structure. </LI> <LI> Ba<SUB>2</SUB>PrMoO<SUB>6</SUB> exhibits high conductivity of 348.5 Scm<SUP>−1</SUP> under wet CH<SUB>4</SUB> at 800 °C. </LI> <LI> High conductivity under wet CH<SUB>4</SUB> is correlated with the carbon deposition. </LI> <LI> Activation energy of Ba<SUB>2</SUB>PrMoO<SUB>6</SUB> and Ba<SUB>2</SUB>NdMoO<SUB>6</SUB> for H<SUB>2</SUB> oxidation is 1.09 and 1.19 eV. </LI> </UL> </P>

In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease

Rath, Surya Narayan,Jena, Lingaraja,Bhuyan, Rajabrata,Mahanandia, Nimai Charan,Patri, Manorama Korea Genome Organization 2021 Genomics & informatics Vol.19 No.1

Levodopa (L-DOPA) therapy is normally practised to treat motor pattern associated with Parkinson disease (PD). Additionally, several inhibitory drugs such as Entacapone and Opicapone are also cosupplemented to protect peripheral inactivation of exogenous L-DOPA (~80%) that occurs due to metabolic activity of the enzyme catechol-O-methyltransferase (COMT). Although, both Entacapone and Opicapone have U.S. Food and Drug Administration approval but regular use of these drugs is associated with high risk of side effects. Thus, authors have focused on in silico discovery of phytochemicals and evaluation of their effectiveness against human soluble COMT using virtual screening, molecular docking, drug-like property prediction, generation of pharmacophoric property, and molecular dynamics simulation. Overall, study proposed, nine phytochemicals (withaphysalin D, withaphysalin N, withaferin A, withacnistin, withaphysalin C, withaphysalin O, withanolide B, withasomnine, and withaphysalin F) of plant Withania somnifera have strong binding efficiency against human COMT in comparison to both of the drugs i.e., Opicapone and Entacapone, thus may be used as putative bioenhancer in L-DOPA therapy. The present study needs further experimental validation to be used as an adjuvant in PD treatment.

The effect of root canal irrigants on dentin: a focused review

Rath, Priti Pragati,Yiu, Cynthia Kar Yung,Matinlinna, Jukka Pekka,Kishen, Anil,Neelakantan, Prasanna The Korean Academy of Conservative Dentistry 2020 Restorative Dentistry & Endodontics Vol.45 No.3

Despite the vast literature on the effects of root canal irrigants on the dentin characteristics, the precise effects of clinically relevant irrigation sequences remain unclear. In this review, we systematically dissect the role of different sequential irrigation approaches that are used in clinical endodontics. Using a systematic search strategy, we attempt to answer the question: 'Which irrigating sequence has the most deleterious effects on dentin structure and properties?' The effect of irrigants on the dentin composition and mechanical properties have been reviewed. A wide variety of concentrations, duration and techniques have been employed to characterize the effects of chemicals on dentin properties, thus making it impossible to draw guidelines or recommendations of irrigant sequences to be followed clinically. It was apparent that all the studied irrigation sequences potentially result in some deleterious effects on dentin such as decrease in the flexural strength, microhardness, modulus of elasticity and inorganic content and organic-inorganic ratio of the dentin. However, the literature still lacks comprehensive investigations to compare the deleterious effect of different irrigation sequences, using a wide variety of qualitative and quantitative methods. Such investigations are essential to make clinical recommendations and strategize efforts to minimize chemically-induced damage to dentin characteristics.

Effect of Mating Delay and Mating Duration on Reproductive Performance of Antheraea mylitta

Rath, S. S.,Narain, Raj,Singh, M. K.,Suryanarayana, N. Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.14 No.2

Tropical tasar silkmoth Antheraea mylilta D. is an economically important insect. The wild nature and above all unsynchronized emergence of moths lead to impairment in reproductive activity. The mating in moths is low (64%-70%), leaving about 30-36% of potential females unused for seed (= egg) production. Delay in mating adversely affects the reproductive performance such as mating behaviour, fecundity and fertility. Females are more severely affected by mating delay than males. Therefore, a study was under taken to develop a method to overcome the problem so that the production of layings can be increased to meet the ever increasing demand. It was revealed from the study that out of 16 possible age combinations (from the age groups of day 0 to day 3), female and male of day 0 (4-8 hours old) excel in their reproductive performance than others (with 94.4% mating success, 284 fecundity and 91.5% hatching). Reproductive performance declined significantly even if one of the parents was older. When either of the mating pair was 1 day old, the mating declined by 28%; fecundity by 32.8%; and hatching by 40.8%. The insemination of eupyrene sperm was declined by 35.2% when both the parents are 1 day old. Mating duration of 8 hours resulted in insemination of $8.3{\times}10^5$ eupyrene sperms, which was declined by 31.6%, 48% and 55% upon lowering of mating duration to 6 hr, 4 hr and 2 hr were maintained respectively.