Epidemiological Aspects of Osteosarcoma, Giant Cell Tumor and Chondrosarcoma Musculoskeletal Tumors - Experience of the National Rehabilitation Institute, Mexico City

DelaGarza-Montano, P,Estrada-Villasenor, E,Dominguez Rubio, R,Martinez-Lopez, V,Avila-Luna, A,Alfaro-Rodriguez, A,Garciadiego-Cazares, D,Carlos, A,Hernandez-Perez, AD,Bandala, C Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: Primary bone neoplasms are rare, contributing only 0.2% of the global burden of all human malignancies. Osteosarcoma (OS) and chondrosarcoma (CS) are the most common malignancies of bone. The giant cell tumor of bone (GCTb) is a benign tumor with behavior characterized by osteolytic bone destruction. The OS, CS and GCTb affect both sexes, all races and generally have incidence peaks regarding the age of the patient which vary according to the tumor type. We analyzed the incidences of OS, CS and GCTb and their relations with gender and age in patients treated in the National Rehabilitation Institute (INR, for its acronym in Spanish) over a period of nine years. Materials and Methods: In the study period, clinic pathological data for 384 patients were obtained with clinical, radiological and histopathological diagnosis for OS, GCTb and CS. Data analysis was performed using the chi-square and Fisher's exact tests. Results: From 2006 to 2014 were recorded 384 cases of bone malignancies in the database of INR. The GCTb had the highest incidence (53.1%), followed by OS (31.3%) and finally the CS (15.6%). The overall average age was $33.6{\pm}15.8$ years and the overall frequency of gender had a ratio of 1/1.03 male/female. The states with the highest incidence were Distrito Federal and Estado de Mexico with 29.2% and 25.3% respectively. Malignant neoplasms of bone assessed in the course of nine years show three significant increases in 2008, 2011 and 2014 (p=0.14). We found association between sex and tumor type (p=0.03), GCTb and CS predominated in females (54.9% and 56.6% respectively), while for the OS males were most affected (59.1%). Age was different in relation with tumor type (p=0.0001), average age was $24.3{\pm}11.2$ years for OS, $34.5{\pm}13$ years for GCTb and $49.2{\pm}18.5$ years for CS. Furthermore, associations of tumor type with topographic location of the primary tumor (P=0.0001) were found. Conclusions: In this study we can see that incidence of musculoskeletal tumor in our population is continuously increasing and in nine years an approximately 200% increase of musculoskeletal tumor cases was observed.

Association of Metastasis with Clinicopathological Data in Mexican Patients with Osteosarcoma, Giant Cell Tumor of Bone and Chondrosarcoma

Estrada-Villaseor, E,Escamilla-Uribe, R,De la Garza-Montano, P,Dominguez-Rubio, R,Martinez-Lopez, V,Avila-Luna, A,Alfaro-Rodriguez, A,Ruvalcaba-Paredes, EK,Garciadiego-Cazares, D,Bandala, C Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: Bone tumors are neoplasias with a high overall mortality; one of the main factors that reduce survival is their high capacity to develop metastases. It has been reported that finding lung metastases at diagnosis of osteosarcoma (OS), chondrosarcoma (CS) and giant cell tumor of bone (GCTb) is quite common. In this study, we inquire the relationship of metastases caused by these tumors with different clinical and pathological aspects, in order to guide medical personnel in the diagnosis and opportune treatment of metastases or micro metastases. Materials and Methods: We collected data of 384 patients with clinical, radiological and histopathological diagnosis of OS, GCTb and CS that attended the National Rehabilitation Institute (INR) during 2006 to 2014. Chi-square and Fisher's exact tests were performed for data analysis. Results: In the three tumor types, the presence of metastases at diagnosis was variable (p=0.0001). Frequency of metastases was 36.7%, 31.7% and 13.2% for OS, CS and GCTb respectively. The average age had no significant difference (p>0.05) in relation to metastases, even so, patients with OS and GCTb and metastases, were older while patients with CS and metastases were younger, in comparison to patients without metastases. Males had a higher frequency of metastases (68.2%, p = 0.09) in contrast to CS and GCTb, in which the metastases was more frequent in women with 51.9% (p = 0.44) and 57.9% (p = 0.56) respectively. Broadly, metastasis was associated with primary tumors located in the femur (44.4%), followed by the tibia (15.6%); metastases was more frequent when primary tumor of GCTb and OS were in the same bones, but were located in the hip (26.3%) for CS. Conclusions: The frequency of metastases in OS, GCTb and CS is high in our population and is determined by different clinicopathological variables related to the kind of tumor. Further studies are needed in order to evaluate metastases subsequent to diagnosis and associations with survival and clinicopathological factors, as well as to determine the sensitivity and specificity of current methods of detection.

Effect of Testosterone Solution 2% on Testosterone Concentration, Sex Drive and Energy in Hypogonadal Men: Results of a Placebo Controlled Study

Brock, G.,Heiselman, D.,Maggi, M.,Kim, S.W.,Rodriguez Vallejo, J.M.,Behre, H.M.,McGettigan, J.,Dowsett, S.A.,Hayes, R.P.,Knorr, J.,Ni, X.,Kinchen, K. Williams and Wilkins Co 2016 The Journal of urology Vol.195 No.3

<P>Purpose: We determined the effect of testosterone solution 2% on total testosterone level and the 2 symptoms of hypogonadism, sex drive and energy level. Materials and Methods: This was a randomized, multicenter, double-blind, placebo controlled, 16-week study to compare the effect of testosterone and placebo on the proportion of men with a testosterone level within the normal range (300 to 1,050 ng/dl) upon treatment completion. We also assessed the impact of testosterone on sex drive and energy level measured using SAID (Sexual Arousal, Interest and Drive scale) and HED (Hypogonadism Energy Diary), respectively. A total of 715 males 18 years old or older with total testosterone less than 300 ng/dl and at least 1 symptom of testosterone deficiency (decreased energy and/or decreased sexual drive) were randomized to 60 mg topical testosterone solution 2% or placebo once daily. Results: Of study completers 73% in the testosterone vs 15% in the placebo group had a testosterone level within the normal range at study end point (p < 0.001). Participants assigned to testosterone showed greater baseline to end point improvement in SAID scores (low sex drive subset p < 0.001 vs placebo) and HED scores (low energy subset p = 0.02 vs placebo, not significant at prespecified p < 0.01). No major adverse cardiovascular or venous thrombotic events were reported in the testosterone group. The incidence of increased hematocrit was higher with testosterone vs placebo (p = 0.04). Conclusions: Once daily testosterone solution 2% for 12 weeks was efficacious in restoring normal testosterone levels and improving sexual drive in hypogonadal men. Improvement was also seen in energy levels on HED though not at the prespecified p < 0.01. No new safety signals were identified.</P>

Shell evolution of <i>N</i> = 40 isotones towards ⁶⁰Ca: First spectroscopy of ⁶²Ti

Corté,s, M.L.,Rodriguez, W.,Doornenbal, P.,Obertelli, A.,Holt, J.D.,Lenzi, S.M.,Mené,ndez, J.,Nowacki, F.,Ogata, K.,Poves, A.,Rodrí,guez, T.R.,Schwenk, A.,Simonis, J.,Stroberg, S.R. North-Holland Pub. Co 2020 Physics letters. Section B Vol.800 No.-

<P><B>Abstract</B></P> <P>Excited states in the N = 40 isotone <SUP>62</SUP>Ti were populated via the <SUP>63</SUP>V ( p , 2 p ) <SUP>62</SUP>Ti reaction at ∼200 MeV/nucleon at the Radioactive Isotope Beam Factory and studied using <I>γ</I>-ray spectroscopy. The energies of the 2 1 + → 0 gs + and 4 1 + → 2 1 + transitions, observed here for the first time, indicate a deformed <SUP>62</SUP>Ti ground state. These energies are increased compared to the neighboring <SUP>64</SUP>Cr and <SUP>66</SUP>Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for <SUP>62</SUP>Ti show a dominant configuration with four neutrons excited across the N = 40 gap. Likewise, they indicate that the N = 40 island of inversion extends down to Z = 20 , disfavoring a possible doubly magic character of the elusive <SUP>60</SUP>Ca.</P>

SUNSHINE, EARTHSHINE AND CLIMATE CHANGE: II. SOLAR ORIGINS OF VARIATIONS IN THE EARTH'S ALBEDO

GOODE P. R.,PALLE E.,YURCHYSHYN V.,QIU J.,HICKEY J.,RODRIGUEZ P. MONTANES,CHU M.-C.,KOLBE E.,BROWN C.T.,KOONIN S.E. The Korean Astronomical Society 2003 Journal of The Korean Astronomical Society Vol.36 No.suppl1

There are terrestrial signatures of the solar activity cycle in ice core data (Ram & Stoltz 1999), but the variations in the sun's irradiance over the cycle seem too small to account for the signature (Lean 1997; Goode & Dziembowski 2003). Thus, one would expect that the signature must arise from an indirect effect(s) of solar activity. Such an indirect effect would be expected to manifest itself in the earth's reflectance. Further, the earth's climate depends directly on the albedo. Continuous observations of the earthshine have been carried out from Big Bear Solar Observatory since December 1998, with some more sporadic measurements made during the years 1994 and 1995. We have determined the annual albedos both from our observations and from simulations utilizing the Earth Radiation Budget Experiment (ERBE) scene model and various datasets for the cloud cover, as well as snow and ice cover. With these, we look for inter-annual and longer-term changes in the earth's total reflectance, or Bond albedo. We find that both our observations and simulations indicate that the albedo was significantly higher during 1994-1995 (activity minimum) than for the more recent period covering 1999-2001 (activity maximum). However, the sizes of the changes seem somewhat discrepant. Possible indirect solar influences on the earth's Bond albedo are discussed to emphasize that our earthshine data are already sufficiently precise to detect, if they occur, any meaningful changes in the earth's reflectance. Still greater precision will occur as we expand our single site observations to a global network.

Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers

Chaluvally-Raghavan, P.,Zhang, F.,Pradeep, S.,Hamilton, Mark P.,Zhao, X.,Rupaimoole, R.,Moss, T.,Lu, Y.,Yu, S.,Pecot, Chad V.,Aure, Miriam R.,Peuget, S.,Rodriguez-Aguayo, C.,Han, H.D.,Zhang, D.,Venkat Cell Press 2014 CANCER CELL Vol.26 No.6

Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated as miR569), which is overexpressed in a subset of ovarian and breast cancers, at least in part due to the 3q26.2 amplicon, alters cell survival and proliferation. Downregulation of TP53INP1 expression by miR569 is required for the effects of miR569 on survival and proliferation. Targeting miR569 sensitizes ovarian and breast cancer cells overexpressing miR569 to cisplatin by increasing cell death both in vitro and in vivo. Thus targeting miR569 could potentially benefit patients with the 3q26.2 amplicon and subsequent miR569 elevation.

Performance of carbon fiber added to anodes of conductive cement-graphite pastes used in electrochemical chloride extraction in concretes

M. J. Pellegrini-Cervantes,C. P. Barrios-Durstewitz,R. E. Nú,ñ,ez-Jaquez,F. J. Baldenebro-Lopez,R. Corral-Higuera,S. P. Arredondo-Rea,M. Rodriguez-Rodriguez,O. Llanes-Cardenas,R. Beltran-Chaco 한국탄소학회 2018 Carbon Letters Vol.26 No.-

Pollution of chloride ion-reinforced concrete can trigger active corrosion processes that reduce the useful life of structures. Multifunctional materials used as a counter-electrode by electrochemical techniques have been used to rehabilitate contaminated concrete. Cement-based pastes added to carbonaceous material, fibers or dust, have been used as an anode in the non-destructive Electrochemical Chloride Extraction (ECE) technique. We studied the performance of the addition of Carbon Fiber (CF) in a cement-graphite powder base paste used as an anode in ECE of concretes contaminated with chlorides from the preparation of the mixture. The experimental parameters were: 2.3% of free chlorides, 21 days of ECE application, a Carbon Fiber Volume Fraction (CFVF) of 0.1, 0.3, 0.6, 0.9%, a lithium borate alkaline electrolyte, a current density of 4.0 A / m2 and a cement/graphite ratio of 1.0 for the paste. The efficiency of the ECE in the traditional technique using metal mesh as an anode was 77.6% and for CFVF of 0.9% it was 90.4%, with a tendency to increase to higher percentages of the CFVF in the conductive cement-graphite paste, keeping the pH stable and achieving a homogeneous ECE in the mass of the concrete contaminated with chlorides.

Mode Adaptive Droop Control With Virtual Output Impedances for an Inverter-Based Flexible AC Microgrid

Jaehong Kim,Guerrero, J M,Rodriguez, P,Teodorescu, R,Kwanghee Nam IEEE 2011 IEEE TRANSACTIONS ON POWER ELECTRONICS - Vol.26 No.3

<P>A decentralized power control method in a single-phase flexible ac microgrid is proposed in this paper. Droop control is widely considered to be a good choice for managing the power flows between microgrid converters in a decentralized manner. In this work, to enhance the power loop dynamics, droop control combined with a derivative controller is used in islanded mode. In grid-connected mode, to strictly control the power factor in the point of common coupling (PCC), a droop method combined with an integral controller is adopted. Small-signal analysis of the proposed control is shown both in islanded and grid-connected mode. The proposed control scheme does not need any mode switching action. Thus, it is relatively simple in control for full mode of operation. Smooth transitions between the operation modes and the effectiveness of the proposed control scheme are evaluated through simulation and experimental results.</P>

Electrical percolation and fluidity of conductive recycled mortar cement: graphite powder: recycled sand with addition of industrial waste carbon fiber

Espinoza-Moreno C. A.,Rodriguez-Rodriguez M.,Pellegrini-Cervantes M. J.,Barrios-Durstewitz C. P.,Núñez-Jaquez R. E.,Peinado-Guevara H. J.,Chinchillas-Chinchillas M.,Fajardo-San-Miguel G. 한국탄소학회 2021 Carbon Letters Vol.31 No.4

The use of recycled materials, such as the fne recycled aggregate made from concrete waste and carbon fber (CF) product of industrial waste, for the manufacture of conductive recycled mortars (CRM), transforms the mortar base cement normally made with cement:sand in a sustainable multifunctional material, conferring satisfactory mechanical and electrical properties for non-structural uses. This action provides ecological benefts, reducing the use of natural fne aggregates from rivers and the amount of concrete waste deposited in landflls resulting from construction waste. In this investigation the efect of the addition of CF on electrical properties in hardened, wet and dry state, electric percolation in dry state and fuidity of the wet mixture of a cement based CRM was evaluated: fne recycled aggregate: graphite powder, CRM specimens with dimensions of 4×4×16 cm. were manufactured for 3, 7 and 28 days of age and sand/cement ratios=1.00, graphite/cement=1.00, water/cement=0.60 and CF=0.1, 0.3, 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0% compared to the weight of cement. The results demonstrated the efect of the addition of CF in CRM, reducing fuidity of the mixtures due to the opposition generated by its physical interaction of CF with recycled sand or recycled fne aggregate and graphite powder (GP), in its case, placing the electric percolation percolation at 0.30% and 0.45% of CF for CRM with and without GP, respectively. Increases in electrical conductivity (EC) without the presence of GP are defned by the contact between the CF and the conductive paths formed. In contrast, with the presence of GP, the EC is defned by the contact between the CF and the GP simultaneously, forming conductive routes with greater performance in its EC.

복강경하 탈장 수술

박재갑,김희철,김선회,박용현,R.A. Lauderdale,R.P. Rodriguez 대한외과학회 1992 대한외과학회 학술대회 초록집 Vol.1992 No.11