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- 저자 : Quynh T. Thi (검색결과 8 건)
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Quynh T N Nguyen,Jiwon Park,Dong Yeol Kim,Sang-Min Kim,Hyun Jae Sung,Thuy-Duong Thi Tran,Ngan An Bui,Inn-Oc Han 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
Repeated sublethal hypoxia exposure is reported to accelerate brain inflammation, and to affect the initiation and progression of cognitive dysfunction. Forskolin, an adenylate cyclase activator, is well-known as an inducer of the cAMP/PKA/CREB signaling. It has been shown that forskolin protects against various neuronal complications and induces long term memory; however, the underlying mechanism remains unclear. In this study, we showed that intraperitoneal administration of 200ng/g forskolin for 5 days on zebrafish notably recovered hypoxia-induced social interaction impairment and learning memory deficit. Forskolin suppressed hypoxia-induced neuroinflammation indicated by the decrease of NF-kB signaling and GFAP expression. On mouse neuroblastoma cell line, forskolin notably rescued hypoxia-induced cell death and dysfunction. The hypoxia model either in vivo or in vitro exerted a downregulation of PKA/CREB signaling and its downstream, c-Fos and BDNF expression, which was restored by forskolin. As previous studies proposed that hypoxia-induced hypo-O-GlcNAcylation could be an important causal factor for cognitive defect, we further investigated whether the HBP/O-GlcNAcylation cycling was changed by forskolin. Intriguingly, we observed that following forskolin treatment, OGT protein level (enzyme controls the addition of GlcNAc group to target proteins) induced considerably, which was accompanied by the upregulated O-GlcNAcylation level. Under forskolin treatment, O-GlcNAcylation flux on hypoxia-exposed zebrafish was reserved in line with the recovery of other inflammation and learning/memory markers. Next, we studied further about potential regulation of O-GlcNAcylation on the neuroprotective effect of forskolin. Zebrafish were treated with 500ng/g 6-diazo-5-oxo-L-norleucine (DON), an inhibitor of GFAT1 (enzyme that catalyzes the reaction from fructose-6-P to glucosamine-6-P), to downregulate the O-GlcNAcylation of proteins. It was observed that DON treatment led to learning/memory impairment, which was rescued by forskolin. Moreover, forskolin conserved hypo-O-GlcNAcylation and neuroinflammation following DON administration. Further experiments are being conducted to examine how HBP/O-GlcNAc flux is involved in the beneficial effect of forskolin on cognitive function.
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Effect of Co substitution on ferrimagnetic Heusler compound Mn3Ga
Nguyen Quynh Anh T.,Ho Thi H.,Jung Myung-Hwa,Rhim Sonny H. 한국물리학회 2023 Current Applied Physics Vol.49 No.-
Effect of Co substitution on Mn3Ga is investigated using first-principles study for structural and magnetic properties. Without Co, ferrimagnetic Heusler compound Mn3Ga is in tetragonal phase. With Co substitution, depending on Co concentration (x), Mn3Ga prefers tetragonal (cubic) phase when x ≤ 0.5 ( x ≥ 0.5). Ferrimagnetism is robust regardless of x in both phases. While magnetic moments of two Mn do not vary significantly with x, magnetic moments of Co in two phases exhibit different behaviors, leading to distinct features in absolute value of total magnetic moment (|Mtot |). When x ≤ 0.5, in tetragonal phase, magnetic moment of Co is vanishingly small, resulting in a decrease of |Mtot | with x. In contrast, when x ≥ 0.5, in cubic phase, magnetic moment of Co is roughly 1μB, which is responsible for the increase of |Mtot |. Electronic structure is analyzed with partial density of states for various x. To elucidate the counterintuitively small Co moment, the magnetic exchange interaction is investigated, where exchange coefficient between Co and Mn(II) in x ≤ 0.5 is much smaller than that in x ≥ 0.5.
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Glucosamine relieves high fat diet-induced fatty liver through autophagy
Jiwon Park,Quynh T N Nguyen,Dong Yeol Kim,Sang-Min Kim,Thuy-Duong Thi Tran,Hyun Jae Sung,Ngan An Bui,Inn-Oc Han 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
Glucosamine (GlcN) is the amino sugar that increases the protein O-GlcNAcylation level by going into the hexosamine biosynthesis pathway (HBP pathway). Previous studies have reported that GlcN regulates autophagy in various organs including the brain, cartilage, and retina. However, its regulating mechanism and role in the liver are still unclear. Here, we observed glucosamine induces autophagy in human hepatocytes (HepG2). Moreover, LC3, one of the most important factors of autophagy, was upregulated by GlcN at the transcriptional and protein levels. We hypothesized that the HBP pathway is involved in GlcN-induced autophagy. Therefore, examined with inhibition of two enzymes, O-GlcNacase and O-GlcNAc transferase, which have an opposite role in the HBP pathway. As a result, the autophagy process was regulated by O-GlcNAcylation levels. To provide the role of GlcN in the liver autophagy process, we conducted the GlcN effect on the fatty liver, known autophagy disrupted disease. Palmitic acid (PA) induced autophagy inhibition and fat accumulation was relieved by GlcN in HepG2 cells. In addition, high-fat diet-induced fatty liver was restored by GlcN through autophagy in mice. Our results indicate that GlcN increased autophagy flux and through this, lipid accumulation can be restored both in vivo and in vitro.
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Hossein Moayedi,Yinghao Zhao,Loke Kok Foong,Quynh T. Thi 국제구조공학회 2024 Smart Structures and Systems, An International Jou Vol.33 No.1
The use of five optimization techniques for the prediction of a strength-based concrete mixture's best-fit model is examined in this work. Five optimization techniques are utilized for this purpose: Slime Mold Algorithm (SMA), Black Hole Algorithm (BHA), Multi-Verse Optimizer (MVO), Vortex Search (VS), and Whale Optimization Algorithm (WOA). MATLAB employs a hybrid learning strategy to train an artificial neural network that combines least square estimation with backpropagation. Thus, 72 samples are utilized as training datasets and 31 as testing datasets, totaling 103. The multi-layer perceptron (MLP) is used to analyze all data, and results are verified by comparison. For training datasets in the best-fit models of SMAMLP, BHA-MLP, MVO-MLP, VS-MLP, and WOA-MLP, the statistical indices of coefficient of determination (R<sup>2</sup>) in training phase are 0.9603, 0.9679, 0.9827, 0.9841 and 0.9770, and in testing phase are 0.9567, 0.9552, 0.9594, 0.9888 and 0.9695 respectively. In addition, the best-fit structures for training for SMA, BHA, MVO, VS, and WOA (all combined with multilayer perceptron, MLP) are achieved when the term population size was modified to 450, 500, 250, 150, and 500, respectively. Among all the suggested options, VS could offer a stronger prediction network for training MLP.
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LE, Tri D.,NGUYEN, Tan T.,NGUYEN, Phuong N.D.,NGUYEN, Thi Quynh Trang Korea Distribution Science Association 2022 유통과학연구 Vol.20 No.11
Purpose: Increasing competition in the higher education sector has prompted universities to enhance their marketing efforts and understand their potential customers. The study aims to explore how information sources are used and changed among prospective Vietnamese students during the decision-making process. Research Design, Data, and Methodology: This study undertakes a longitudinal study involving multiple rounds of data collection to better understand the decision-making process of prospective students. Data was collected from 12th -grade students in Vietnam through two rounds of quantitative surveys with 251 students and one round of qualitative interviews, spanning the duration of their senior year. The three stages of the decision-making process correspond to the three stages of pre-purchase period. Results: Most students decide that attending open days, taking career assessments, and looking up information online are the most important information sources to consider. The WOM sources are more important in the early stages, while university-generated sources and events are important in the later stages. Conclusion: Implications from this study may contribute to the design of more effective marketing communications campaigns as university marketers gain a better understanding of the distribution of information sources utilized for each specific stage of the decision-making process.
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REM sleep deprivation impairs learning and memory by decreasing brain O-GlcNAc cycling in mouse
Sang-Min Kim,Jiwon Park,Hyun Jae Sung,Ngan An Bui,Quynh T N Nguyen,Thuy-Duong Thi Tran,Dong Yeol Kim,Inn-Oc Han 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
Rapid eye movement (REM) sleep is associated with learning and memory (L/M) functions. Here, we demonstrate that REM sleep deprivation (REMSD)-induced impairment of contextual fear memory and spatial memory in mouse is linked to a downregulation in hexosamine biosynthetic pathway (HBP)/O-GlcNAc flux in mouse brain. In mice exposed to REMSD, O-GlcNAcylation proteins and O-GlcNAc transferase (OGT) were decreased while O-GlcNAcase was increased compared to control mouse brain. Foot shock fear conditioning (FC) induced activation of protein kinase A (PKA) and cAMP response element binding protein (CREB), which were significantly inhibited in brains of the REMSD group. Intriguingly, increasing O-GlcNAc cycling with glucosamine (GlcN) or OGA inhibitor, Thiamet G, restored defects in L/M functions and FC-induced PKA/CREB activation induced by REMSD. On behavior test, GlcN restored the contextual fear memory and spatial memory impairment induced by REMSD. Furthermore, Thiamet G restored the REMSD-induced decrease in dendritic spine density and learning and memory impairment. Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6‐diazo‐5‐oxo‐l‐norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function and inhibited FC-induced PKA/CREB activation. To our knowledge, this is the first study to provide comprehensive evidence of dynamic O-GlcNAcylation changes during the L/M process in mice and defects in this pathway in the brain of REM sleep-deprived mice. Our collective results highlight HBP/O-GlcNAc cycling as a novel molecular link between sleep and cognitive function.
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