Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China

Xie, Xiang-Quan,Zheng, Kui-Cheng,Wu, Bing-Shan,Chen, Tie-Hui,Lai, Shan-Rong,Lin, Zai-Sheng,Aoki, Kazuo The Korean Society for Preventive Medicine 2014 Journal of Preventive Medicine and Public Health Vol.47 No.5

Objectives: In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increased risk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogen I:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthy dietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developing gastric cancer than those in Nanjing do.

Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China

Xiang-Quan Xie,Kui-Cheng Zheng,Bing-Shan Wu,Tie-Hui Chen,Shan-Rong Lai,Zai-Sheng Lin,Kazuo Aoki 대한예방의학회 2014 Journal of Preventive Medicine and Public Health Vol.47 No.5

Objectives: In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increasedrisk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogenI:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthydietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developinggastric cancer than those in Nanjing do.

Investigation of the Mechanism of Period-doubling Bifurcation in Voltage Mode Controlled Buck-Boost Converter

Xie, Ling-Ling,Gong, Ren-Xi,Zhuo, Hao-Ze,Wei, Jiong-Quan The Korean Institute of Electrical Engineers 2011 Journal of Electrical Engineering & Technology Vol.6 No.4

An investigation of the mechanism of period-doubling bifurcation in a voltage mode controlled buck-boost converter operating in discontinuous conduction mode is conducted from the viewpoint of nonlinear dynamical systems. The discrete iterative model describing the dynamics of the close-loop is derived. Period-doubling bifurcation occurs at certain values of the feedback factor. Results from numerical simulations and experiments are provided to verify the evolution of perioddoubling bifurcation, and the results are consistent with the theoretical analysis. These results show that the buck-boost converters exhibit a wide range of nonlinear behavior, and the system exhibits a typical period-doubling bifurcation route to chaos under particular operating conditions.

FK866 inhibits colorectal cancer metastasis by reducing NAD+ levels in cancer-associated fibroblasts

Xie Hanhan,Lei Yun,Mao Yushan,Lan Jingbin,Yang Jing,Quan Hui,Zhang Tao 한국유전학회 2022 Genes & Genomics Vol.44 No.12

Background: Extraintestinal metastasis is the main therapeutic challenge for colorectal cancer, the third most common cancer worldwide. Various components of the tumor microenvironment, especially cancer-associated fibroblasts (CAFs), play important roles in tumor metastasis. NAMPT is often overexpressed in tumor tissues and is associated with poorer prognosis. However, the specific roles of NAMPT as well as NAD+ in tumor metastasis are relatively unknown. Therefore, we investigated the role of NAMPT and related NAD+ metabolism in cancer-associated fibroblasts mediated colorectal cancer metastasis. Objective: This study sought to explore the molecular mechanism of FK866 in CAFs cell and colorectal cancer proliferation and metastasis. Methods: The expression of NAMPT in clinical tissues were detected by immunohistochemically analysis. To investigate the role of NAMPT and NAD+ in the interactions between cancer cells and cancer-associated fibroblasts in tumor microenvironment, we isolated CAFs from normal and cancer tissues of clinical colorectal cancer patients. CAFs were treated with different concentrations of FK866, inhibitor of NAMPT, then the NAD+ content was detected using kits, the expression of CAFs activity and stemness indexes was assessed by Western blot and immunofluorescence. The secreted factors of these cells were analyzed by cellular inflammatory factor microarrays. The migration of SW480 after co-cultured with FK866-treated CAFs was detected by Transwell. Finally, high-throughput sequencing was performed to identify the proteins that are associated with the effect of altered NAD+ in CAFs on the migration of cancer cells. Results: NAMPT expression is significantly higher in colorectal cancer tissues, especially in metastatic cancer patients, than that in normal tissues. Inhibition of NAMPT by FK866 in CAFs decreases the expression of activity indicators (α-SMA, PDGFRβ), stemness indicators (BMI-1, OCT4), inflammatory factors and chemokines. Meanwhile, FK866 treatment inhibits the migration ability of SW480 cells co-cultured with CAFs. Finally, high-throughput sequencing reveals that PITX3 are down-regulated after NAD+ reduction in CAFs, which could be reversed by adding NAM, a raw material for NAD+ synthesis. Conclusion: Inhibition of the NAMPT-mediated NAD+ synthesis by FK866 may decrease the activation and stemness of CAFs, reduce the secretion of inflammatory and chemokines by suppressing the expression of PITX3, resulting in the suppression of colorectal cancer metastasis.

Gestational Diabetes Mellitus and Subsequent Cancer Risk: Shared Risk Factors, Causality or Confounding?

Xie, Shao-Hua,Yang, Shu-Juan,Chen, Juan,Cheng, Jin-Quan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Low Molecular Weight Organic Acids in Brassica pekinensis Rupr. and Growing soil Influenced by Simulated Nitrate Deposition

Xie, Wen-Ming,Liu, Xing-Quan,Ko, Kwang-Yong,Lee, Kyu-Seung The Korean Society of Environmental Agriculture 2008 한국환경농학회지 Vol.27 No.3

We investigated whether carboxylate exudation of Brassica pekinensis Rupr. was affected by nitrate deposition from simulated acid rain. A gas chromatographic (GC) analysis was employed for the determination of low molecular weight organic acids (LOA) in rhizosphere soils, bulk soil, roots and leaves of Brassica pekinensis Rupr.. Rhizosphere soils were collected after 8 weeks of plant growth by first removing the bulk soil from the root system and then by mechanical move off the rhizosphere soil that adhered to the root surface with soft brush. Soil and plant materials were simultaneously extracted with the mixture of methanol and sulfuric acid (100:7, v/v). Seven organic acids, oxalic, malonic, fumaric, succinic, maleic, L-malic and citric acid were identified and quantified by GC equipped with FID. Oxalic, L-malic, and citric acids were found in both the bulk and rhizosphere soils, while most LOAs were not detected in the control treatment. On the contrary, except maleic acid, all other organic acids were detected in the leaves and roots of cabbages treated with nitrate deposition.

Study on the Moisture and Thermal Characteristics of Vegetated Expansive Soil Slopes

Quan Shen,Yidan Zhang,Canrong Xie,Chengli Zhang,ChaoHui Wang 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.6

The moisture and thermal characteristics of expansive soil slopes have a significant impact on the strength and overall stability of the soil. In this study, the medium-strength expansive soil vegetated slope in Baise, Guangxi, was taken as the research object. Through the combination of numerical simulation and measured meteorological data, the impact of moisture and heat characteristics on slope stability was then analyzed, and optimal geometric parameters conducive to the stability of vegetated slopes were proposed based on these findings. The research results indicate that under long-term climatic conditions, solar net radiation has the most sensitive effect on the evaporation of slope soil. During the evaporation process, vegetation transpiration dominates in the vegetation-covered layer, while below the depth of the vegetation cover layer, soil evaporation itself plays a dominant role. Under the conditions of evaporation-rainfall-evaporation, slopes with a smaller permeability coefficient in the vegetation cover layer have significantly higher safety factors than slopes with a larger permeability coefficient and bare slopes. A steep vegetated slope with a slope gradient of 50° can maintain slope stability with proper handling of its height. The research findings have reference value for the design and construction of vegetated slopes with expansive soil.

A self-assembly and stimuli-responsive fusion gelonin delivery system for tumor treatment

Quan Liu,Lu Zhang,Xiuru Ji,Meong Cheol Shin,Shuping Xie,Baoyan Pan,Fei Yu,Jingwen Zhao,Victor C. Yang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-

Ribosome-inactivating proteins (RIPs) are potent protein toxins for cancer therapy, and they have strongability to inhibit protein synthesis and induce cell death via inactivation of ribosomes in eukaryotic cells. However, the delivery of RIPs has been a challenging task due to their large molecular weight and lack oftargeting property. Low molecular weight protamine (LMWP), a transmembrane peptide, has beenproved to effectively promote transmembrane transportation, whereas the enzyme-activatable systemcan enhance the specificity by enhancing the tumor drug concentration through enzymatic reaction. Weherein constructed a self-assembly and stimuli-responsive fusion gelonin delivery system. Gelonin, atypical RIP protein, was assembled with nickel ferrite nanoparticles by self-assembling between hexa-histidine tag (His-tagged) and nickel ions. Both in vitro and in vivo results indicated that the magneticnanoparticle carriers and the applied linkers did not damage the pharmaceutical effect of gelonin, andthe whole drug delivery system showed good biocompatibility, sensitive selectivity, and significantlyenhanced cytotoxic activity. This in turn presented theranostic nanoparticles as efficient delivery vehiclefor clinical use.

[Oral Session 3] STUDIES OF DUAL COMPONENT AND MICROPARTICALE RETENTION SYSTEM IN PAPERMAKING ON DYNAMIC DRAINAGE CONDITION

Xie Lai-Su,Wang Hai-Yi,Chen Fu-Shan,Long Yan-Quan 한국펄프·종이공학회 1999 한국펄프종이학회 기타 간행물 Vol.- No.-

This paper dealt with effect of dual component and micropartical retention system on papermaking. First-pass retention under dynamic drainage condition was studied in neutral and alkaline papermaking system. Cationic starches, amphoteric starches and amphoteric polyacrylamide were added prior to high shear force, then anionic microparticle (colloidal silica or bentonite clay) were added. The system is found to be very useful to improve filler retention. For mitigating unfavorable effect of interfering sub-stances [I] , anionic trash catcher (ATC)such as p-DADMAC was tested in this study.

[Oral Session 1] STUDY OF AMPHOTERIC POLYACRYLAMIDE USED AS RETENTION AND DRAINAGE AIDS IN PAPERMAKING

Xie Lai-Su,Wang Hai-Yi,Chen Fu-Shan,Long Yan-Quan 한국펄프·종이공학회 1999 한국펄프종이학회 기타 간행물 Vol.- No.-

In this paper, a series of amphoteric polyacrylamide (PAM) with different molecular weight and charge were synthesized and used as retention and dewatering aids. Better products had been selected and tested under varied conditions. Effects of molecular weight, cationic charge density, degree of hydrolysis<br/> and other factors of PAM on retention and dewatering of papermaking were also considered. Finally, synthesized quaternary and tertiary ammonium amphoteric polyacrylamide were practised in paper mill trial.