Clinical Efficacy of Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer Patients with Liver Metastases: A Network Meta-Analysis of Nine Randomized Controlled Trials

Qing Yin,Longguo Dai,Ruizhu Sun,Ping Ke,Liya Liu,Bo Jiang 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3

Purpose This network meta-analysis (NMA) was conducted to compare the efficacy of immune checkpoint inhibitors in advanced non–small cell lung cancer (NSCLC) patients with liver metastases.Materials and Methods English literature was retrieved from the PubMed, American Society of Clinical Oncology, and European Society for Medical Oncology databases from January 2015 to January 2021. We pooled the overall survival (OS) and progression-free survival (PFS) hazard ratios (HRs) using an NMA and ranked treatments by the surface under the cumulative ranking curve. Publication bias was evaluated by Begg’s and Egger’s tests. STATA 15.0 was used for the sensitivity analysis, and the remaining statistical analyses were performed using R 4.0.2.Results Nine eligible phase III randomized controlled trials were included, including 1,141 patients with liver metastases. Pembrolizumab+chemotherapy ranked highest, followed by atezolizumab+bevacizumab+chemotherapy and nivolumab. However, no significant difference in OS rates was observed across these three treatments (HR, 0.98; 95% confidence interval [CI], 0.43 to 2.22 for pembrolizumab+chemotherapy vs. atezolizumab+bevacizumab+chemotherapy; HR, 0.91; 95% CI, 0.52 to 1.57 for pembrolizumab+chemotherapy vs. nivolumab). Regarding the PFS rate, atezolizumab+bevacizumab+chemotherapy and pembro-lizumab+chemotherapy ranked highest and no significant difference was observed between them (HR, 0.79; 95% CI, 0.36 to 1.70 for atezolizumab+bevacizumab+chemotherapy vs. pembrolizumab+chemotherapy).Conclusion Pembrolizumab+chemotherapy, atezolizumab+bevacizumab+chemotherapy, and nivolumab were superior to other treatments in NSCLC patients with liver metastases. These new findings may help clinicians better select therapeutic strategies for NSCLC patients with liver metastases.

Inverter Power Monitoring System Based on VRML Virtual Reality Technology

Qing-yun Dai,Jin-dou Wang,Rui-Tao Liu,Jun-hong Cheng,Yi li,Wei-yang Wu 보안공학연구지원센터 2013 International Journal of Smart Home Vol.7 No.5

Research of DSP-based Embedded Systems Connected to the Internet

Qing-yun Dai,Jin-dou Wang,Rui-tao Liu,Jun-hong Cheng,Yi li 보안공학연구지원센터 2013 International Journal of Hybrid Information Techno Vol.6 No.6

First-principles calculations on ferroelectricity and lattice dynamics of Type-II multiferroic SmMn2O5

Dai Jian-Qing,Yuan Jin 한국물리학회 2021 Current Applied Physics Vol.29 No.-

In this work, we report on the structural, electronic, and ferroelectric properties of SmMn2O5 by using firstprinciples density functional theory plus on-site Coulomb interaction (DFT + U) calculations. A thorough analysis was preformed to reveal the competing characteristics of different high-temperature (T) phases and the polarization mechanism in the low-T multiferroic phase. We show that the structural characteristics of the high-T phases have a strong influence on the low-T multiferroicity. In addition to the spin-induced lattice distortion that reduces substantially the purely electronic ferroelectricity, the dominant polarization mechanism in low-T SmMn2O5 still originates from the electronic polarization. By performing mode decomposition of the Hellmann– Feynman forces and the lattice distortion induced by the q = (0.5, 0, 0) magnetic order, we find that the Raman-active Ag mode characterized by the Mn4+O6 octahedron distortion and synergistic displacement of Mn3+ and Sm ions is of primary importance, while the infrared (IR)-active B2u mode plays a secondary role. These findings provide a theoretical foundation for future studies concerning the enhanced magnetoelectric effects of SmMn2O5 due to its pure exchange–striction mechanism.

Genome sequence of lung pathogenic Escherichia coli O78, a chimeric strain isolated from pneumonia forest musk deer

Qing Tian,Xin Zhou,Jianguo Cheng,Yan Luo,Lei Dai,Wei Zhao,Wuyou Wang 한국유전학회 2017 Genes & Genomics Vol.39 No.7

Pneumonia is one of the major diseases of forest musk deer (FMD) that affects the survival of musk deer breeding farms. Lung pathogenic Escherichia coli (LPEC) strains were found to be one of the principal bacterial pathogens, and O78 was found to be the dominant serotype and the most poisonous, thus it was selected as further study. Here we have finished the LPEC O78 genome sequence, genomic comparative analysis and genome annotation. In the genome of LPEC O78, genes encoded major virulence factors (VFs) of urinary tract infection (UTI) and neonatal meningitis-causing E. coli (NMEC) were detected. The phylogenetic analysis indicated that LPEC O78 belongs to the D group of E. coli and clustered with human uropathogenic E. coli (UPEC) UMNO26. Orthologous analysis showed that LPEC O78 was close to UMNO26 in evolutionary relationships, the results were consistent with phylogenetic analysis. Additionally, analysis of the specific genes using COG, GO and Swiss-Prot databases revealed specific functions in the LPEC O78, some of these differences might reflect the pathogenicity of LPEC O78. It was the first time that LPEC from FMD was sequenced, through the virulence gene analysis, an example of a genome of chimeric pathogenic properties was found. The results were in favor of the possibility that strain of animal origin LPEC O78 was dangerous for public health and consequently constitute a zoonotic risk. Moreover, the functions study of specific genes will facilitate understand the pathogenicity of LPEC O78, and aid in the development of control measures.

Control of Electrically Excited Synchronous Motors with a Low Switching Frequency

Qing-qing Yuan,Xiao-jie Wu,Peng Dai,Xiao Fu 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.4

The switching frequency of the power electronic devices used in large synchronous motor drives is usually kept low (less than 1 kHz) to reduce the switching losses and to improve the converter power capability. However, this results in a couple of problems, e.g. an increase in the harmonic components of the stator current, and an undesired cross-coupling between the magnetization current component (im) and the torque component (it). In this paper, a novel complex matrix model of electrically excited synchronous motors (EESM) was established with a new control scheme for coping with the low switching frequency issues. First, a hybrid observer was proposed to identify the instantaneous fundamental component of the stator current, which results in an obvious reduction of both the total harmonic distortion (THD) and the low order harmonics. Then, a novel complex current controller was designed to realize the decoupling between im and it. Simulation and experimental results verify the effectiveness of this novel control system for EESM drives.

Research of Decision Tree Classification Algorithm in Data Mining

Qing-yun Dai,Chun-ping Zhang,Hao Wu 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.5

Rotor Initial Position Estimation Based on sDFT for Electrically Excited Synchronous Motors

Qing-qing Yuan,Xiao-jie Wu,Peng Dai 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3

Rotor initial position is an important factor affecting the control performance of electrically excited synchronous motors. This study presents a novel method for estimating rotor initial position based on sliding discrete Fourier transform (sDFT). By injecting an ac excitation into the rotor winding, an induced voltage is generated in stator windings. Through this voltage, the stator flux can be obtained using a pure integral voltage model. Considering the influence from a dc bias and an integral initial value, we adopt the sDFT to extract the fundamental flux component. A quadrant identification model is designed to realize the accurate estimation of the rotor initial position. The sDFT and high-pass filter, DFT, are compared in detail, and the contrast between dc excitation and ac injection is determined. Simulation and experimental results verify that this type of novel method can eliminate the influence of dc bias and other adverse factors, as well as provide a basis for the control of motor drives.

PVT1 knockdown inhibited the biological behavior of LPS-induced cardiac fibroblasts by regulating miR-24

Dai Qing,Hong Yi,Li Jie 한국유전학회 2021 Genes & Genomics Vol.43 No.9

Background The heart is one of the target organs vulnerable to sepsis. About 50% of sepsis patients will sufer from myocardial injury and cardiac dysfunction, which will aggravate the sepsis and afect its prognosis. Objectives Here, we attempt to investigate the function of long non coding RNA PVT1 in LPS-induced cardiac fbroblasts in vitro, and explore its potential mechanism. Methods The expression of PVT1 in LPS-induced cardiac fbroblasts was detected by qRT-PCR. CCK-8 assay, cell migration, qRT-PCR and western blotting analysis were applied to evaluating the efect of PVT1 knockdown on LPS-induced cardiac fbroblasts. The bioinformatics analysis and the rescue experiment were devoted to the underlying mechanism. Results PVT1 expression was up-regulated in LPS-induced cardiac fbroblasts. And knockdown of PVT1 inhibited cell viability and migration, alleviated infammation cytokines production of LPS-treated cardiac fbroblasts. The bioinformatics analysis predicted PVT1 negatively regulates miR-24 and KLF6 is a direct target of miR-24. Conclusions In a word, we observed PVT1 expression level was up-regulated in LPS- treated cardiac fbroblasts. PVT1 knockdown could alleviate LPS-induced biological behavior of cardiac fbroblasts through sponging miR-24 in vitro.

A novel strengthened dispersed particle gel for enhanced oil recovery application

Caili Dai,Wenxia Chen,Qing You,Hong Wang,Yang Zhe,Long He,Baolei Jiao,Yining Wu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.41 No.-

A novel strengthened dispersed particle gel (SDPG) was proposed and investigated to improve hightemperatureand high-salinity stability of foam, which uses silica nanoparticles as reinforcing material tosupport the inner framework of particle gel. In this paper, SDPG was successfully prepared and applied toa new three-phase foam system (STPFS). Indoor experiments were conducted to evaluate the salttolerance, thermal tolerance, plugging capacity and enhanced oil recovery capacity of the STPFS. It provedthat silica nanoparticles could improve the high-temperature and high-salinity stability of the gelparticles effectively. Consequently, the new three-phase foam system (STPFS) exhibited superior salt andtemperature resistance, with a salinity of 80,000 mg/L of Na+, 15,000 mg/L of Ca2+ and Mg2+ andtemperature tolerance of 110 C. In addition, core-flooding test indicated the STPFS possessed betterplugging capacity with a resistance factor of 310 and better enhanced oil recovery capacity with the oilrecovery increment of 26.79% under high temperature (110 C) and high salt environment (212,633.8 mg/L).