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박지은,정연재,박준범,김혜영,유영현,이광식,양원태,김도훈,김종민 한국발생생물학회 2019 발생과 생식 Vol.23 No.3
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic BKS.Cg-m+/+Leprdb mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPFfed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.
李鎭局,徐相壽,朴魯峰,李忠鎬,劉鍾哲,金洪奎,趙武濟,韓運東,池平植 충주대 2003 産業科學論文集 Vol.11 No.-
In this paper, we discuss actual conditions for running school of electrical and electronic engineering in domestic universities. Also, we catch hold of industrial circles's demands in electrical engineering education and analyze questionary results according to goes into effect school of electrical and electronic & information engineering in major of electrical and electronec engineering's students. Conclusively, we present suitable model in electrical engineering by correction of problems.
A New Layout Scheme for Macro Cell
Lee, Pyeong Han,Kyung, Chong Min 대한전자공학회 1991 ICVC : International Conference on VLSI and CAD Vol.2 No.1
A new strategy for combining placement and routing of macro cell layout is proposed. The strategy solves a layout problem by interlocking placement and routing in step-wise motion. This approach is significantly different from the conventional approaches which partition IC layout problems into smaller steps and solve each step sequentially resulting in a locally optimal solution. The proposed strategy uses the FDR(Force Directed Relaxation) result as initial placement and consists of module orientation, global routing, block size enlargement and overlap removal procedures.
Kim, Pyeong Su,Lee, Kyung-Muk,Han, Dong-Seok,Yoo, Moon-Won,Han, Hye Seung,Yang, Han-Kwang,Bang, Ho Yoon The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.3
Purpose: Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea. Materials and Methods: We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011. Age, sex, number of metastatic lymph nodes (LNs), number of examined LNs, depth of invasion, and location of the tumor were investigated as variables for validation of the nomogram. Both discrimination and calibration of the nomogram were evaluated. Results: The discrimination was evaluated using Harrell's C-index. The Harrell's C-index was 0.83 and the discrimination of the gastric cancer nomogram was appropriate. Regarding calibration, the 95% confidence interval of predicted survival appeared to be on the ideal reference line except in the poorest survival group. However, we observed a tendency for actual survival to be constantly higher than predicted survival in this cohort. Conclusions: Although the discrimination power was good, actual survival was slightly higher than that predicted by the nomogram. This phenomenon might be explained by elongated life span in the recent patient cohort due to advances in adjuvant chemotherapy and improved nutritional status. Future gastric cancer nomograms should consider elongated life span with the passage of time.