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RISS 인기검색어
- 검색키워드
- 저자 : Purnima Dhanraj Amin (검색결과 2 건)
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Ajay Kumar Sav,Meer Tarique Ali,Ritesh Amol Fule,Purnima Dhanraj Amin 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.5
In current study, highly purified fenugreek gum (HPFG) isolated by patented method explored as emulsifier and hydrophilic solid carrier in drug delivery system. Antihyperlipidemic drug simvastatin (SIM) was selected as drug model for the study as it is associated with poorly water solubility and low bioavailability problems (\5 %). A suitable HPFG-based silica lipid system composed of SIM (1.5 %), medium chain triglyceride Capmul MCM (10 %) as lipid phase, 0.6 % HPFG as emulsifier and HPFG 2.5 %, different grades colloidal silica (7.5 %)(Aerosil 300 Pharma, Aerosil 380 Pharma and Aeroperl 300 Pharma) as hydrophilic solid carriers was developed. The optimized HPFG-based silica lipid systems were characterized for physical characteristics like flow ability,compressibility, redispersiblity, solubility and in vitro drug release using USP apparatus II in pH 6.8 phosphate buffer. The system was also characterized for Fourier transform infrared spectroscopy, powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The developed formulation was found to have excellent flow property, readily redispersiblity, better aqueous solubility and showed 3–4-fold increase in dissolution rate as compared to plain drug and marketed formulation (Simlo 10). Transition of crystalline drug to amorphous state was confirmed by DSC,PXRD and SEM studies. Enhanced dissolution rate and solubility possibly attributed to improved wetting, amorphous drug state and facilitated diffusion from lipid-based system. Thus developed HPFG-based silica lipid system provides an alternative means for SIM with enhanced dissolution rate and stability in oral solid dosage form.
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Avinash Bhaskar Gangurde,Meer T. Ali,Jaywant N. Pawar,Purnima Dhanraj Amin 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.6
Vitamin E (VE) is highly lipophilic in nature with a very low water solubility which degrades rapidly in presence of oxygen, and free-radical mediated oxidative processes. Spray drying of oil-in-water emulsions containing hydrophilic carriers was used to encapsulate lipophilic compounds into powders. The purpose of this study was to prepare microcapsules of VE using different starch derivatives to increase its stability and to disperse it in aqueous environment. Emulsion of VE acetate was prepared using cremophore RH 40 with tween 80 in a homogenizer and then spray dried. The spray process was optimized using a central composite design for two variables to obtain microcapsules with desirable characteristics. Microcapsules containing 2, 4 and 6% w/w of VE acetate were produced. The microcapsules were evaluated for their physical, morphological, in vitro release, solid state characterization such as SEM, FTIR, P-XRD and its in vitro free radical scavenging activity. The results showed that obtained microcapsules are nearly spherical in shape with mean particle size of microcapsules were ranged from 1 to 12 lm. The drug content and encapsulation efficiency (53–63%) was found to be uniform and within acceptable range. Optimized formulations were kept for 3 months stability study and found to be stable.
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