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- 저자 : Pruksakorn, Dumnoensun (검색결과 4 건)
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Age-Standardized Incidence Rates and Survival of Osteosarcoma in Northern Thailand
Pruksakorn, Dumnoensun,Phanphaisarn, Areerak,Pongnikorn, Donsuk,Daoprasert, Karnchana,Teeyakasem, Pimpisa,Chaiyawat, Parunya,Katruang, Narisara,Settakorn, Jongkolnee Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Osteosarcoma is a common primary malignant bone tumor in children and adolescents. Recent worldwide average incidences of osteosarcoma in people aged 0 to 24 years were 4.3 and 3.4 per million, respectively, with a ratio of 1.4:1. However, data on the incidence of osteosarcoma in Thailand are limited. This study analyzed the incidence of osteosarcoma in the upper northern region of Thailand, with a population of 5.85 million people (8.9% of the total Thai population), using data for the years 1998 to 2012, obtained from the Chiang Mai Cancer Registry (CMCR) at Chiang Mai University Hospital and the Lampang Cancer Registry (LCR) at the Lampang Cancer Hospital, a total of 144 cases. The overall annual incidence of osteosarcoma was 1.67 per million with a male:female ratio of 1.36:1. Incidences by age group (male and female) at 0 to 24, 25 to 59 and over 60 years were 3.5 (3.9 and 3.0), 0.8 (0.9 and 0.6), and 0.7 (0.8 and 0.5), respectively. The peak incidence occurred at 15 to 19 years for males and at 10 to 14 years for females. The median survival time was 18 months with a 5-year survival rate of 43%. Neither the age group nor the 5-year interval period of treatment was significantly correlated with survival during the 15-year period studied.
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Prevalence and Survival Patterns of Patients with Bone Metastasis from Common Cancers in Thailand
Phanphaisarn, Areerak,Patumanond, Jayantorn,Settakorn, Jongkolnee,Chaiyawat, Parunya,Klangjorhor, Jeerawan,Pruksakorn, Dumnoensun Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9
Background: Bone metastasis is a single condition but presents with various patterns and severities. Skeletal-related events (SREs) deteriorate overall performance status and reduce quality of life. However, guidelines for early detection and management are limited. This study includes a survey of the prevalence of bone metastasis in cases with common cancers in Thailand as well as a focus on survival patterns and SREs. Materials and Methods: A retrospective cohort analysis was conducted using a database of the Chiang Mai Cancer Registry and the Musculoskeletal Tumor Registry of the OLARN Center, Chiang Mai University. The prevalence of bone metastasis from each type of primary cancer was noted and time-to-event analysis was performed to estimate cancer survival rates after bone metastasis. Results: There were 29,447 cases of the ten most common cancers in Thailand, accounting for 82.2% of the entire cancer registry entries during the study period. Among those cases, there were 2,263 with bone metastases, accounting for 7.68% of entries. Bone metastasis from lung, liver, breast, cervix and prostate are common in the Thai population, accounting for 83.4% of all positive cases. The median survival time of all was 6 months. Of the bone metastases, 48.9% required therapeutic intervention, including treatment of spinal cord and nerve root compression, pathological fractures, and bone pain. Conclusions: The frequency of the top five types of bone metastasis in Thailand were different from the frequencies in other countries, but corresponded to the relative prevalence of the cancers in Thailand and osteophilic properties of each cancer. The results of this study support the establishment of country specific guidelines for primary cancer identification with skeletal lesions of unknown origin. In addition, further clinical studies of the top five bone metastases should be performed to develop guidelines for optimal patient management during palliative care.
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Clinical presentation and treatment outcomes of primary ocular adnexal MALT lymphoma in Thailand
Kasem Seresirikachorn,Lalita Norasetthada,Sakarin Ausayakhun,Atitaya Apivatthakakul,Sirima Tangchittam,Vannakorn Pruksakorn,Kitsada Wudhikarn,Damrong Wiwatwongwana 대한혈액학회 2018 Blood Research Vol.53 No.4
BackgroundPrimary ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lym-phoid tissue (POML) is the most common subtype of lymphoma involving the eyes in Thailand. We sought to assess the characteristics and treatment outcomes of patients with POML in Thailand.MethodsWe retrospectively reviewed patient data and included patients diagnosed with POML between January 2004 and December 2016 at Chiang Mai University Hospital and King Chulalongkorn Memorial Hospital, Thailand. We collected and analyzed patients’ clinical characteristics and treatment outcomes.ResultsAmong 146 patients with lymphoma involving the eyes, 121 (82%) were diagnosed with POML. Sixty-four (52.9%) were women with median age 58 (range, 22‒86) years. The most common presenting symptom was orbital mass (71.1%). Common sites of origin were the orbit (46.3%) and lacrimal gland (34.7%). At presentation, 22.3% of patients had bilateral eye involvement. About half of patients had stage I disease (N=59, 56.2%) and 20% had stage IV. Most patients (73.3%) had a low-risk International Prognostic Index. Radiotherapy was the main treatment for patients with limited-stage disease (66.7% in stage I and 56.5% in stage II). The overall response rate was 100% with complete response rates 80%, 77.3%, and 64.7% for stages I, II, and IV, respectively. Five-year pro-gression-free survival (PFS) and overall survival were 66.1% and 94.0%, respectively. For patients with limited-stage disease, radiotherapy significantly improved PFS compared with treatment not involving radiotherapy (5-year PFS 89.9% vs. 37.3%, P=0.01).ConclusionWe revealed that POML has good response to treatment, especially radiotherapy, with excellent long-term outcome.
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Jansook Phatsawee,Maw Phyo Darli,Soe Hay Man Saung Hnin,Chuangchunsong Ravinsinee,Saiborisuth Kitisak,Payonitikarn Nawaporn,Autthateinchai Rinrapas,Pruksakorn Patamaporn 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.5
Propose Fungal keratitis is one of the major causes in loss of vision and blindness. Amphotericin B (AmB) is the first-line treatment of keratitis caused by Candida spp. and related fungi. Due to its high molecular weight and low aqueous solubility, it hampers the ocular bioavailability. It is well-known that γ-cyclodextrin (γCD) can enhance AmB solubility. The aim of this study was to investigate the effect of the additives on γCD solubilization of AmB and develop AmB eye drop nanosuspensions. Methods 0.18% (w/v) AmB nanosuspensions containing either 0.25% (w/v) chitosan or 0.10% (w/v) phospholipids (PL) in aqueous γCD eye drop medium were prepared by using high pressure homogenization technique. Physicochemical properties, in vitro mucoadhesive, in vitro permeation, degree of AmB aggregation, hemolytic activity and in vitro antifungal test were determined. Results The physicochemical properties of the nanosuspensions containing AmB/γCD nanoaggregates were in the acceptable range. The particle size of all formulations was in nanometer range. The degree of aggregation was less than 2.0 that meant the drug was not in the aggregate form when solubilized in γCD. These formulations demonstrated relatively low hemolytic activity and effectively improved the antifungal activity. Conclusion AmB/γCD nanosuspension stabilized by 0.10% (w/v) PL is the promising formulation for further studies due to that it was excellent physical appearance, had mucoadhesive property, enhanced in vitro permeation, had low toxicity and improved the antifungal activity.
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