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Intra-Operative Frozen Sections: Experience at A Tertiary Care Centre
Preeti, Agarwal,Sameer, Gupta,Kulranjan, Singh,Abhinav, Sonkar Arun,Preeti, Rani,Sunita, Yadav,Mati, Goel Madhu Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
The present study was conducted to assess error rates with diagnosis using intra-operative frozen sections, and to indicate ways to increase overall performance. Over a period of two years, 227 cases were biopsied intra-operatively. Errors were observed in 14 cases. Four of these were sampling errors, one by a pathologist and three by surgeons. In seven cases incorrect interpretations were made. Epithelial dysplasia was observed on definitive histology in two cases which was not reported intra-operatively. One case was of ectopic thyroid. In cases of oral cancer where sentinel lymph nodes were sampled, immunohistochemistry for cytokeratin was performed to facilitate identification of micrometastasis. Only single case displayed tumor deposits which was not evident morphologically. Resection margins were reported in seventy eight cases. Some 18% (14/50) benefited from revision of margins; overall sensitivity of intra-operative frozen sections for marginal status was 71.4%, with a specificity of 90.3%. Overall sensitivity was 75% and specificity was 97.5%. Careful observation, pathologist experience and knowledge of limitations help in improving the overall diagnostic outcome.
Computation of design forces and deflection in skew-curved box-girder bridges
Preeti Agarwal,Priyaranjan Pal,Pradeep Kumar Mehta 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.78 No.3
The analysis of simply supported single-cell skew-curved reinforced concrete (RC) box-girder bridges is carried out using a finite element based CsiBridge software. The behaviour of skew-curved box-girder bridges can not be anticipated simply by superimposing the individual effects of skewness and curvature, so it becomes important to examine the behaviour of such bridges considering the combined effects of skewness and curvature. A comprehensive parametric study is performed wherein the combined influence of the skew and curve angles is considered to determine the maximum bending moment, maximum shear force, maximum torsional moment and maximum vertical deflection of the bridge girders. The skew angle is varied from 0° to 60° at an interval of 10°, and the curve angle is varied from 0° to 60° at an interval of 12°. The scantly available literature on such bridges focuses mainly on the analysis of skew-curved bridges under dead and point loads. But, the effects of actual loadings may be different, thus, it is considered in the present study. It is found that the performance of these bridges having more curvature can be improved by introducing the skewness. Finally, several equations are deduced in the non-dimensional form for estimating the forces and deflection in the girders of simply supported skew-curved RC box-girder bridges, based upon the results of the straight one. The developed equations may be helpful to the designers in proportioning, analysing, and designing such bridges, as the correlation coefficient is about 0.99.
Singh, Durg Vijay,Agarwal, Shikha,Singh, Preeti,Godbole, Madan Madhav,Misra, Krishna Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
In order to enhance the bioavailability of curcumin its conjugates with piperic acid and glycine were synthesized by esterifying the 4 and 4' phenolic hydroxyls, the sites of metabolic conjugation. Antiproliferative and apoptotic efficacy of synthesized conjugates was investigated in MCF-7 and MDA-MB-231 cell lines. $IC_{50}$ values of di-O-glycinoyl (CDG) and di-O-piperoyl (CDP) esters of curcumin were found to be comparable with that of curcumin. Both conjugates induced chromatin condensation fragmentation and apoptotic body formation. CDP exposure to MCF-7 cells induced apoptosis initiating loss of mitochondrial membrane potential (${\Delta}{\Psi}m$) followed by inhibition of translocation of transcription factor NF-${\kappa}B$ and release of Cytochrome-C. Reactive oxygen species (ROS) production was evaluated by fluorescent activated cell sorter. Change in ratio of Bcl2/Bclxl was observed, suggesting permeablization of mitochondrial membrane leading to the release of AIF, Smac and other apoptogenic molecules. DNA fragmentation as a hallmark for apoptosis was monitored by TUNEL as well as agrose gel electrophoresis. Thus, it was proven that conjugation does not affect the therapeutic potential of parent molecule in vitro, while these could work in vivo as prodrugs with enhanced pharmacokinetic profile. Pharmacokinetics of these molecules under in vivo conditions is a further scope of this study.