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α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus
Elbandy, Mohamed,Shinde, Pramod B.,Hong, Jong-Ki,Bae, Kyung-Sook,Kim, Mi-Ae,Lee, Sang-Mong,Jung, Jee H. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.1
New $\alpha$-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 ${\mu}g/mL$.
Chemical Investigation of the Sea Cucumber Stichopus japonicus
Pramod B. Shinde,Hung The Dang,Huayue Li,홍종기,신숙,정지형 한국생약학회 2008 Natural Product Sciences Vol.14 No.1
A chemical investigation of the polar extract of the sea cucumber Stichopus japonicus, collected from Jeju Island, Korea, has led to isolation of five new fatty acid derivatives (1, 4 - 7) along with known compounds (2 - 3, 8 - 14). Their structures were elucidated by a combination of MS and NMR spectroscopy.
Cytotoxic Polyketides from the Marine Sponge Discodermia calyx
Shinde, Pramod B.,Mansoor, Tayyab A.,Luo, Xuan,Hong, Jong-Ki,Lee, Chong-O.,Jung, Jee-H. Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.6
Bioassay-guided fractionation of the MeOH extract from the sponge Discodermia calyx collected off the coast of Jeju Island, South Korea, led to the isolation of a polyketide, icadamide C (1), along with previously reported theopederin K (3). Structure elucidation was performed by a combination of high resolution mass and 2D-NMR (principally COSY, HMBC, HSQC, and NOESY) spectroscopy. Stereochemistry of compound 1 was determined as 2R*, 3R*, 6R*, 10S*, 11S*, 12R*, 13S*, 15R* and 2'S by NMR data and Marfey analysis. Isolated metabolites displayed potent cytotoxic activity against a small panel of five human solid tumor cell lines with ED50 values of less than 0.1 μg/mL.
Cytotoxic Polyketides from the Marine Sponge Discodermia calyx
Pramod B. Shinde,Tayyab A. Mansoor,Xuan Luo,홍종기,Chong-O. Lee,정지형 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.6
Bioassay-guided fractionation of the MeOH extract from the sponge Discodermia calyx collected off the coast of Jeju Island, South Korea, led to the isolation of a polyketide, icadamide C (1), along with previously reported theopederin K (3). Structure elucidation was performed by a combination of high resolution mass and 2D-NMR (principally COSY, HMBC, HSQC, and NOESY) spectroscopy. Stereochemistry of compound 1 was determined as 2R*, 3R*, 6R*, 10S*, 11S*, 12R*, 13S*, 15R* and 2'S by NMR data and Marfey analysis. Isolated metabolites displayed potent cytotoxic activity against a small panel of five human solid tumor cell lines with ED50 values of less than 0.1 mg/mL.
Apocarotenoids from an Association of Two Marine Sponges
정지형,Pramod B. Shinde,Mi Ae Kim,Byeng Wha Son,Lee Chong-O 한국생약학회 2007 Natural Product Sciences Vol.13 No.4
fractionation of MeOH extract of an association of two sponges, Jaspis sp. andPoecillastra sp. resulted in isolation of four apocarotenoids (1 -4). Their structures were determined on the basisof MS and NMR spectroscopic analyses and by direct comparison with those of reported. This is the first reporton isolation of these compounds from any sponge. Isolated metabolites were evaluated for cytotoxicity against asmall panel of solid human tumor cell lines.KeywordsMarine sponge, Jaspis sp., Poecillastra sp., Apocarotenoids, Allene, Cytotoxicity
Trisoxazole Macrolide from a Marine Sponge Sarcotragus Species
Yonghong Liu,Pramod B. Shinde,Jongki Hong,Lee Chong-O,Kwang Sik Im,Jee H. Jung 한국생약학회 2005 Natural Product Sciences Vol.11 No.1
Bioassay-directed fractionation of the lipophilic extract of a marine sponge Sarcotragus sp. led to theisolation of a known trisoxazole containing macrolide, mycalolide B (1). Its structure was identified by NMR andMS analyses. This is the first report on the isolation of macrolide from a sponge of the genus Sarcotragus (Order:Dictyoceratida).
α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus
Mohamed Elbandy,Pramod B. Shinde,홍종기,Kyung Sook Bae,Mi Ae Kim,Sang Mong Lee,정지형 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.1
New α-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 μg/mL.
Characterization of FK506 Biosynthetic Intermediates Involved in Post-PKS Elaboration
Ban, Yeon Hee,Shinde, Pramod B.,Hwang, Jae-yeon,Song, Myoung-Chong,Kim, Dong Hwan,Lim, Si-Kyu,Sohng, Jae Kyung,Yoon, Yeo Joon American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.6
<P>The post-PKS modification steps of FK506 biosynthesis include C9-oxidation and 31-<I>O</I>-methylation, but the sequence of these reactions and the exact route have remained unclear. This study details the post-PKS modification pathways in FK506 biosynthesis through the identification of all intermediates and in vitro enzymatic reactions of the cytochrome P450 hydroxylase FkbD and the methyltransferase FkbM. These results complete our understanding of post-PKS modification steps to FK506 showing the substrate flexibility of two enzymes involved and the existence of two parallel biosynthetic routes to FK506.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-6/np4001224/production/images/medium/np-2013-001224_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np4001224'>ACS Electronic Supporting Info</A></P>