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( Sadan Dahal ),( Prakash Chaudhary ),( Yi-sook Jung ),( Jung-ae Kim ) 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.2
Prostate cancer is the fifth leading cause of cancer-related mortality in men, primarily because of treatment resistance, recurrence, and metastasis. In the present study, we investigated the role of paracrine interleukin-8 (IL-8) in the antagonistic expression of IL-8 and androgen receptor (AR), and the contribution of IL-8 to prostate cancer aggressiveness. In hormone-responsive LNCaP cells that do not express IL-8, recombinant IL-8 treatment significantly increased expressions of IL-8, CXC chemokine receptor 2 (CXCR2), matrix metalloproteinase (MMP)-2/9, Snail, and vimentin. IL-8 treatment significantly decreased AR and E-cadherin expression. IL-8-induced gene expression changes were suppressed by navarixin, a CXCR1/2 inhibitor, and gallein, a Gβγ inhibitor. In PC-3 androgen-refractory prostate cancer cells, IL-8 knockdown reduced expressions of CXCR2, MMP-2/9, Snail, and vimentin, and increased AR and E-cadherin expressions at the mRNA and protein levels. Co-culture with MEG-01 human megakaryocytic cells secreting high levels of IL-8 induced gene expression changes in both LNCaP and PC-3 cells, similar to those induced by IL-8 treatment. The altered gene expressions were accompanied by significant activation of transcription factor Snail in LNCaP and PC-3 cells. Treatment with the CXCR blocker navarixin inhibited the invasion of PC-3 cells but not LNCaP cells. However, invasion induced by MEG-01 was inhibited by navarixin in both LNCaP and PC-3 cells. The collective findings demonstrate that IL-8 enhances CXCR2 expression, which antagonistically regulates AR expression. More importantly, through changes in IL-8/CXCR2-regulated gene expression, IL-8 induces antiandrogen therapy resistance and epithelial-mesenchymal transition in prostate cancer.
Development of a resilient cable joint for the insulation system of oil tanks
Park Hong Seok,Dahal Prakash 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.11
This paper presents the development procedure for a resilient cable joint that adaptively holds the insulating layer outside the wall of oil storage tanks. The proposed cable joint system produces an appropriate and reliable tension force that always firmly attaches the insulating layer to the tank wall regardless of dimensional variations in the tank. These variations are functions of seasonal ambient temperature and hydrostatic pressure. Systematic design procedure and finite element analysis were applied to calculate complex variations in the circumferential displacement of the tank wall. The design and specification of the resilient cable joint system were determined by applying TRIZ principles to avoid the rupture of the cable or the failure of the elastic elements in the cable joint. The developed flexible cable joint results in longer service duration and safer conditions for the cable and insulation system of oil storage tanks.
Development of a new concrete pipe molding machine using topology optimization
박홍석,Trung Thanh Nguyen,Prakash Dahal 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.8
Sulfur polymer concrete (SPC) is a relatively new material used to replace Portland cement for manufacturing sewer pipes. The objective of this work is to develop an efficient molding machine with an inner rotating die to mix, compress and shape the SPC pipe. First, the alternative concepts were generated based on the TRIZ principles to overcome the drawbacks of existing machines. Then, the concept scoring technique was used to identify the best design in terms of machine structure and product quality. Finally, topology optimization was applied with the support of the density method to reduce mass and to displace the inner die. Results showed that the die volume can be reduced by approximately 9% and the displacement can be decreased by approximately 3% when compared with the initial design. This work is expected to improve the manufacturing efficiency of the concrete pipe molding machine.
Development of a Concept to Optimize the Energy Efficiency in Forging Process Chains
Denkena, Berend,Park, Hong-Seok,Behrens, Bernd-Arno,Henjes, Jan,Bertys, Sebastian,Dahal, Prakash,Luken, Ingo,Klassen, Andreas Korean Society for Precision Engineering 2013 International Journal of Precision Engineering and Vol.14 No.7
In the industrial production, approaches for the optimization of process chains mainly focus on criteria like quality, costs and time. Normally the energy consumption of process chains is not considered, although the variation of process parameters is an important possibility to reduce the consumption significantly. Besides that, the investigated processes are often optimized locally without considering the interaction between the different process elements of the whole process chain. Based on this background the developed concept realizes the optimization of the energy consumption of a forging process chain by adaptation of its energetic relevant parameters. Therefore, the concept defines at first variation intervals for the energetic most significant parameters of a forging process chain. After that, the resulting technical/technological modifications are evaluated energetically. To enable a holistic optimization of the process chain, the approach includes the use of a simulation model. The application of the concept has been approved with a simulation model of a 4-cylinder-crankshaft process chain. With the parameter variations 'reduction of the forging temperature', 'reduction of the raw part volume' and 'reduction of the forging time' three possibilities to reduce the energy consumption were identified successfully.
Development of a Concept to Optimize the Energy Efficiency in Forging Process Chains
Berend Denkena,박홍석,Bernd-Arno Behrens,Jan Henjes,Sebastian Bertys,Prakash Dahal,Ingo Lüken,Andreas Klassen 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
In the industrial production, approaches for the optimization of process chains mainly focus on criteria like quality, costs and time. Normally the energy consumption of process chains is not considered, although the variation of process parameters is an important possibility to reduce the consumption significantly. Besides that, the investigated processes are often optimized locally without considering the interaction between the different process elements of the whole process chain. Based on this background the developed concept realizes the optimization of the energy consumption of a forging process chain by adaptation of its energetic relevant parameters. Therefore, the concept defines at first variation intervals for the energetic most significant parameters of a forging process chain. After that, the resulting technical/technological modifications are evaluated energetically. To enable a holistic optimization of the process chain, the approach includes the use of a simulation model. The application of the concept has been approved with a simulation model of a 4-cylinder-crankshaft process chain. With the parameter variations “reduction of the forging temperature”,“reduction of the raw part volume” and “reduction of the forging time” three possibilities to reduce the energy consumption were identified successfully.