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- 저자 : Pradeep Kumar Bhatia (검색결과 4 건)
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An Overview on Taxol Production Technology and Its Applications as Anticancer Agent
Aparajita Sharma,BHATIA SHASHI KANT,Aditya Banyal,Ishita Chanana,Anil Kumar,Duni Chand,Saurabh Kulshrestha,Pradeep Kumar 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.5
Cancer is undeniably a major health risk factor that is growing rapidly globally despite promising medicinal and pharmaceutical development. Treatment of cancer remains an issue due to financial constrains in most of the developing countries. The majority of todayʼs medicines are derived from medicinal plants, as we all know. Taxol is such a plant-based chemotherapeutic agent which has blown the anticancer research field. The extinction of Taxus spp., which is the main natural source of taxol synthesis, required the development of novel alternative approaches in the oncology field. Many novel discoveries have been in trend in which endophytic microbial fermentation process is more focused as this area is cost-efficacious, less time consumable, and eco-friendly. Endophytes are one of another alternative approach for the taxol production, preserving the natural resources of Taxus plants worldwide. Endophytic microorganisms can be exploited in the taxol industry because most of the endophytic microbes have yet to be explored for the eco-friendly and economical production of this wonder drug. The aim of this review article is to cover everything from the discovery of taxol through the development of new natural resource-based biotechnology techniques. Furthermore, the current review has emphasised the use of taxol in fields other than anti-cancer properties, as well as pointing to some future opportunities.
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Analytical Modelling Approach To Measure The Usability of Website
Renuka Nagpal,Deepti Mehrotra,Pradeep Kumar Bhatia 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.5
The aim of the study this to propose the usability metrics of the website and design an algorithm to evaluate it. The usability of websites depends on its structural dimension, functionality and user satisfaction. In this paper, the case study of the website of academic institutions is considered. Key criteria that affect the usability of the website were identified. Each of these criteria's is evaluated using the suitable method for given six sample website of academic institutes. Entropy approach is used for weights estimation and calculation of overall usability metrics.
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Mital Tanya,Kamal Manoj,Kumar Mritunjay,Kumar Rakesh,Bhatia Pradeep,Singariya Geeta 대한마취통증의학회 2021 Anesthesia and pain medicine Vol.16 No.4
Background: Epidural block placement in pediatric patients is technically challenging for anesthesiologists. The use of ultrasound (US) for the placement of an epidural catheter has shown promise. We compared landmark-guided and US-guided lumbar or lower thoracic epidural needle placement in pediatric patients.Methods: This prospective, randomized, comparative trial involved children aged 1–6 years who underwent abdominal and thoracic surgeries. Forty-five children were randomly divided into two groups using a computer-generated random number table, and group allocation was performed by the sealed opaque method into either landmark-guided (group LT) or real-time ultrasound-guided (group UT) epidural placement. The primary outcome was a comparison of the procedure time (excluding US probe preparation). Secondary outcomes were the number of attempts (re-insertion of the needle), bone contacts, needle redirection, skin-to-epidural distance using the US in both groups, success rate, and complications.Results: The median (interquartile range [IQR]) time to reach epidural space was 105.5 (297.0) seconds in group LT and 143.0 (150) seconds in group UT; P = 0.407). While the first attempt success rate was higher in the UT group (87.0% in UT vs. 40.9% in LT; P = 0.004), the number of bone contacts, needle redirections, and procedure-related complications were significantly lower. Conclusions: The use of US significantly reduced needle redirection, number of attempts, bone contact, and complications. There was no statistically significant difference in the time to access the epidural space between the US and landmark technique groups.
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Rahul Madhukar Kashyap,Pradeep Bhatia,Tanvi M. Meshram,Swati Chhabra,Rakesh Kumar 대한노인병학회 2024 Annals of geriatric medicine and research Vol.28 No.2
Background: Older patients are particularly vulnerable to age-related respiratory changes. This prospective randomized controlled trial studied the effects of high and low fractions of inspired oxygen (FiO2 ) with the recruitment maneuver (RM) during extubation on lung atelectasis postoperatively in older patients undergoing major abdominal surgery. Methods: We randomized a total of 126 patients aged >60 years who underwent both elective and emergency major abdominal surgeries and met the inclusion criteria into three groups (H, HR, and LR) using computer-generated block randomization. Group H received high FiO2 (1), Group HR received high FiO2 (1) with RM followed by a positive end-expiratory pressure of 5 cm H2 O, and Group LR received low FiO2 (0.4) with RM followed by a positive end-expiratory pressure of 5 cm H2 O 10 minutes before extubation. Oxygenation and atelectasis were measured using the arterial partial pressure of oxygen (PaO2 )/FiO2 ratios and lung ultrasound score. Postoperative pulmonary complications were recorded up to 24 hours postoperatively. Results: The mean PaO2 /FiO2 at 30 minutes post-extubation was significantly higher in Groups LR and HR compared to that in Group H (390.71±29.55, 381.97±24.97, and 355.37±31.70; p<0.001). In the immediate postoperative period, the median lung ultrasound score was higher in Group H than that in Groups LR and HR (6 [5–7], 3 [3–5], and 3.5 [2.25–4.75]; p<0.001). The incidence of oxygen desaturation and oxygen requirements was higher in Group H during the postoperative period. Conclusion: The RM before extubation is beneficial in reducing atelectasis and postoperative pulmonary complications, irrespective of the FiO2 concentration used in older adults undergoing major abdominal surgeries. (Trail registration number: Reference No. CTRI/2022/04/042115; date of CTRI registration 25/02/2022; and date of enrolment of the first research participant 05/05/2022)
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