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( Poudel Jeeban ),김원태 ( Won Tae Kim ),엄태인 ( Tae In Ohm ),오세천 ( Sea Cheon Oh ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.5
Torrefaction is a thermal treatment process to pre-treat biomass at temperature of 200~300 oC under aninert atmosphere. It was known that torrefaction process strongly depended on the decomposition temperature of the lignocellulosicconstituents in biomass. In this work, the torrefaction characteristics of baggase has been studied. This studyfocuses on the relation between the energy yields, heating values, gas emission, volatile and ash constituents with torrefactiontemperatures and times. The activation energies of baggase torrefaction has been studied by using TGA (ThermogravimetricAnalyzer). From this work, it was seen that ash constituents and heating values were increased withtorrefaction temperature, while volatile constituents and energy yields decreased. It was also found that carbon monoxidecontaining oxygen were decomposed at a lower temperature than those of hydrocarbon compounds, CxHy.
Poudel, Sher Bahadur,Bhattarai, Govinda,Kook, Sung-Ho,Shin, Yun-Ji,Kwon, Tae-Ho,Lee, Seung-Youp,Lee, Jeong-Chae Elsevier 2017 Growth hormone & IGF research Vol.36 No.-
<P><B>Abstract</B></P> <P>Transgenic plant cell suspension culture systems have been utilized extensively as convenient and efficient expression systems for the production of recombinant human growth factors. We produced insulin-like growth factor-1 using a plant suspension culture system (p-IGF-1) and explored its effect on new bone formation in calvarial defects. We also compared the bone regenerating potential of p-IGF-1 with commercial IGF-1 derived from <I>Escherichia coli</I> (e-IGF-1). Male C57BL/6 mice underwent calvarial defect surgery, and the defects were loaded with absorbable collagen sponge (ACS) only (ACS group) or ACS impregnated with 13μg of p-IGF-1 (p-IGF-1 group) or e-IGF-1 (e-IGF-1 group). The sham group did not receive any treatment with ACS or IGFs after surgery. Live μCT and histological analyses showed critical-sized bone defects in the sham group, whereas greater bone formation was observed in the p-IGF-1 and e-IGF-1 groups than the ACS group both 5 and 10weeks after surgery. Bone mineral density, bone volume, and bone surface values were also higher in the IGF groups than in the ACS group. Local delivery of p-IGF-1 or e-IGF-1 more greatly enhanced the expression of osteoblast-specific markers, but inhibited osteoclast formation, in newly formed bone compared with ACS control group. Specifically, p-IGF-1 treatment induced higher expression of alkaline phosphatase, osteocalcin, and osteopontin in the defect site than did e-IGF-1. Furthermore, treatment with p-IGF-1, but not e-IGF-1, increased mineralization of MC3T3-E1 cells, with the attendant upregulation of osteogenic marker genes. Collectively, our findings suggest the potential of p-IGF-1 in promoting the processes required for bone regeneration.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We explored bone regenerating potential of IGF-1 produced by a plant culture system. </LI> <LI> Local delivery of IGF-1 increased bone formation in calvarial defect model of mice. </LI> <LI> IGF-1 treatment stimulated the expression of osteogenic marker genes in the defect. </LI> <LI> The IGF-1 induced new bone formation similar to that did a commercial IGF-1. </LI> <LI> These results support a clinical usefulness of the IGF-1 in repairing bone defects. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Poudel, Bijay Kumar,Gupta, Biki,Ramasamy, Thiruganesh,Thapa, Raj Kumar,Pathak, Shiva,Oh, Kyung Taek,Jeong, Jee-Heon,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Oh Elsevier 2017 Colloids and surfaces Biointerfaces Vol.160 No.-
<P><B>Abstract</B></P> <P>Pancreatic cancer has extremely poor prognosis with an 85% mortality rate that results from aggressive and asymptomatic growth, high metastatic potential, and rapid development of resistance to already ineffective chemotherapy. In this study, plasmonic hollow gold nanoshells (GNS) coated with PEGylated thermosensitive lipids were prepared as an efficient platform to ratiometrically co-deliver two drugs, bortezomib and gemcitabine (GNS-L/GB), for combinational chemotherapy and photothermal therapy of pancreatic cancer. Bortezomib was loaded within the lipid bilayers, while gemcitabine was loaded into the hydrophilic interior of the porous GNS via an ammonium sulfate-driven pH gradient method. Physicochemical characterizations and biological studies of GNS-L/GB were performed, with the latter using cytotoxicity assays, cellular uptake and apoptosis assays, live/dead assays, and western blot analysis of pancreatic cancer cell lines (MIA PaCa-2 and PANC-1). The nanoshells showed remotely controllable drug release when exposed to near-infrared laser for site-specific delivery. GNS-L/GB showed synergistic cytotoxicity and improved internalization by cancer cells. High-powered near-infrared continuous wave laser (λ=808nm) effectively killed cancer cells via the photothermal effect of GNS-L/GB, irrespective of cell type in a power density-, time-, and GNS dose-dependent manner. These results suggest that this method can provide a novel approach to achieve synergistic combinational chemotherapy and photothermal therapy, even with resistant pancreatic cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PEGylated thermosensitive lipid-coated hollow gold nanoshells (GNS-L) were prepared. </LI> <LI> GNS-L were co-loaded with hydrophilic gemcitabine and hydrophobic bortezomib. </LI> <LI> NIR irradiation induced drug release for remotely controlled site-specific delivery. </LI> <LI> GNS-L increased cellular uptake and apoptosis in pancreatic cancer cells. </LI> <LI> Direct photothermal killing of cancer cells was observed on NIR laser irradiation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Poudel, Barun,Ki, Hyeon-Hui,Luyen, Bui Thi Thuy,Lee, Young-Mi,Kim, Young-Ho,Kim, Dae-Ki Oxford University Press 2016 Acta biochimica et biophysica Sinica Vol.48 No.2
<P>Non-small cell lung cancer (NSCLC) is the major cancer-related death worldwide with only 14% five-year survival rate. Triticumoside, a phenolic compound present in Triticum aestivum sprout extract, has been recognized to have antiobesity and anti-inflammatory effects. However, the effect of triticumoside on cancer cell proliferation and migration has not been studied. In order to elucidate whether triticumoside exhibits an anticancer effect, cells were incubated with different doses of triticumoside, and apoptosis was assessed by observing cell viability, cellular morphological changes, and annexin-V-fluorescein isothiocyanate/propidium iodide staining. Cell cycle analysis, western blotting, wound healing assay, and quantitative-polymerase chain reaction were also performed. Triticumoside exhibited marked cytotoxicity in the cells in dose-and time-dependent manner. Triticumoside caused morphological changes, including cellular rounding, nuclear condensation, and shrinkage. Likewise, triticumoside enhanced the sub-G1 proportion of cells. Additionally, triticumoside regulated expression of apoptosis-associated proteins, such as B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X, and procaspase-3/9. Triticumoside also inhibited migration of the cells through downregulation of matrix metalloproteinase-2/9 (MMP2/9). Collectively, these results suggest that triticumoside induces apoptosis through caspase-dependent mitochondrial pathway and suppresses migration via inhibition of MMP2/9 in NSCLC A549 cells.</P>
Poudel, S.,Kim, Y.,Gwak, J.S.,Jeong, S.,Lee, Y. Pergamon Press ; Elsevier Science Ltd 2017 Insect biochemistry and molecular biology Vol.88 No.-
Chloroquine, an amino quinolone derivative commonly used as an anti-malarial drug, is known to impart an unpleasant taste. Little research has been done to study chloroquine taste in insects, therefore, we examined both the deterrant properties and mechanisms underlying chloroquine perception in fruit flies. We identified the antifeedant effect of chloroquine by screening 21 gustatory receptor (Grs) mutants through behavioral feeding assays and electrophysiology experiments. We discovered that two molecular sensors, GR22e and GR33a, act as chloroquine receptors, and found that chloroquine-mediated activation of GRNs occurs through S-type sensilla. At the same time, we successfully recapitulated the chloroquine receptor by expressing GR22e in ectopic gustatory receptor neurons. We also found that GR22e forms a part of the strychnine receptor. We suggest that the Drosophila strychnine receptor might have a very complex structure since five different GRs are required for strychnine-induced action potentials.
Poudel Sanjeeb,Shanbhag Sachin 한국유변학회 2022 Korea-Australia rheology journal Vol.34 No.4
The principle of causality constrains the real and imaginary parts of the complex modulus G∗ = G′ + iG′′ via Kramers– Kronig relations (KKR). Thus, the consistency of observed elastic or storage (G′) and viscous or loss (G′′) moduli can be ascertained by checking whether they obey KKR. This is important when master curves of the complex modulus are constructed by transforming a number of individual datasets; for example, during time-temperature superposition. We adapt a recently developed statistical technique called the ‘Sum of Maxwell Elements using Lasso’ or SMEL test to assess the KKR compliance of linear viscoelastic data. We validate this test by successfully using it on real and synthetic datasets that follow and violate KKR. The SMEL test is found to be both accurate and efficient. As a byproduct, the parameters inferred during the SMEL test provide a noisy estimate of the discrete relaxation spectrum. Strategies to improve the quality and interpretability of the extracted discrete spectrum are explored by appealing to the principle of parsimony to first reduce the number of parameters, and then to nonlinear regression to fi ne tune the spectrum. Comparisons with spectra obtained from the open-source program pyReSpect suggest possible tradeoff s between speed and accuracy.