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Constitutive Expression of Interleukin-8 and Intercellular Adhesion Molecule-1 in Human Dental Pulps
Huang, George T.-J.,Nadia Chugal,Potente, Anthony P.,Zhang, Xinli Korean Academy of Oral Biology and the UCLA Dental 1999 International Journal of Oral Biology Vol.24 No.4
The purpose of this study was to analyze ezpression of the chemokine, interleukin-8 (IL-8), and the adbesion molecule, intercellualr adhesion molecule-1 (ICAM-1), in normal and diseased human dental pulp using immunohistochemistry. These two molecules are involved in initiating and maintaining tissue inflammation in response to external insults. Experimental samples consisted of dental pulf from freshly extracted caries-free third molars (normal pulp) and pulps with clinically diagnosed irreversible pulpitis (diseased pulp). In normal pulpal specimens. IL-8 was constitutively expressed by odontoblasts, whereas ICAM-1 was expressed by endothelial cells. In diseased pulps, odontoblasts, endothelial cells, lymphocytes, and macro-phages exhibited IL-8 immunoreactivity; ICAM-1 was detected in endothelial cells and lymphocytes. These findings suggest that odontoblasts may be involved in initating local inflammation subjacent to carious dentin via IL-8 expression. The constitutive expression of ICAM-1 by endothelial cells suggest that ICAM-1 is not the key adhesion molecule that regulates the influx of immune cells from blood into pulpal tissue.