ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease

Lee, J,Hong, Y K,Jeon, G S,Hwang, Y J,Kim, K Y,Seong, K H,Jung, M-K,Picketts, D J,Kowall, N W,Cho, K S,Ryu, H Macmillan Publishers Limited 2012 CELL DEATH AND DIFFERENTIATION Vol.19 No.7

Aberrant chromatin remodeling is involved in the pathogenesis of Huntington's disease (HD) but the mechanism is not known. Herein, we report that mutant huntingtin (mtHtt) induces the transcription of alpha thalassemia/mental retardation X linked (ATRX), an ATPase/helicase and SWI/SNF-like chromatin remodeling protein via Cdx-2 activation. ATRX expression was elevated in both a cell line model and transgenic model of HD, and Cdx-2 occupancy of the ATRX promoter was increased in HD. Induction of ATRX expanded the size of promyelocytic leukemia nuclear body (PML-NB) and increased trimethylation of H3K9 (H3K9me3) and condensation of pericentromeric heterochromatin, while knockdown of ATRX decreased PML-NB and H3K9me3 levels. Knockdown of ATRX/dXNP improved the hatch rate of fly embryos expressing mtHtt (Q127). ATRX/dXNP overexpression exacerbated eye degeneration of eye-specific mtHtt (Q127) expressing flies. Our findings suggest that transcriptional alteration of ATRX by mtHtt is involved in pericentromeric heterochromatin condensation and contributes to the pathogenesis of HD.

Velvetweaving today: A worldwide overview Barbara Setsu Pickett

( Barbara Setsu Pickett ) 복식문화학회 2013 服飾文化硏究 Vol.21 No.3

Velvet is a luxury cloth. In Fashion it dresses the Elite. In Interiors, it covers palace walls and upholsters elegant furniture. In every culture throughout its history velvet``s sumptuous surfaces denotes luxury, status, power, privilege and wealth. My humble aim is to reveal the artisan in the art-to comprehend the mastery of weaving techniques, to understand the design principles, to study the everyday practice of the weavers at work. In the few ateliers that still weave silk velvet by hand, I have documented their processes and now want to share this knowledge with the broader textile community in hopes of expanding the appreciation of their art. I approach as a fellow weaver striving to learn the mechanics, the practical aspects that guide the work from initial idea to finished cloth. I leave the difficulties of establishing provenance and other important analyses to my more learned textile historian colleagues.

Design of Chern insulating phases in honeycomb lattices

Pickett, Warren E.,Lee, Kwan-Woo,Pentcheva, Rossitza Elsevier 2018 Physica. C, Superconductivity Vol.549 No.-

<P><B>Abstract</B></P> <P>The search for robust examples of the magnetic version of topological insulators, referred to as quantum anomalous Hall insulators or simply Chern insulators, so far lacks success. Our groups have explored two distinct possibilities based on multiorbital 3<I>d</I> oxide honeycomb lattices. Each has a Chern insulating phase near the ground state, but materials parameters were not appropriate to produce a viable Chern insulator. Further exploration of one of these classes, by substituting open shell 3<I>d</I> with 4<I>d</I> and 5<I>d</I> counterparts, has led to realistic prediction of Chern insulating ground states. Here we recount the design process, discussing the many energy scales that are active in participating (or resisting) the desired Chern insulator phase.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Design of Chern insulating phases in honeycomb lattices. </LI> <LI> We present a description of how our three groups, working on two different honeycomb lattice materials classes, learned and designed two examples of transition metal oxide nanolayers whose ground states are predicted to be Chern insulators (quantum anomalous Hall insulators). The main features or properties that guided our search are compared and contrasted between the two classes of materials. </LI> </UL> </P>

Velvetweaving today: A worldwide overview

Pickett, Barbara Setsu The Costume Culture Association 2013 服飾文化硏究 Vol.21 No.3

Velvet is a luxury cloth. In Fashion it dresses the Elite. In Interiors, it covers palace walls and upholsters elegant furniture. In every culture throughout its history velvet's sumptuous surfaces denotes luxury, status, power, privilege and wealth. My humble aim is to reveal the artisan in the art-to comprehend the mastery of weaving techniques, to understand the design principles, to study the everyday practice of the weavers at work. In the few ateliers that still weave silk velvet by hand, I have documented their processes and now want to share this knowledge with the broader textile community in hopes of expanding the appreciation of their art. I approach as a fellow weaver striving to learn the mechanics, the practical aspects that guide the work from initial idea to finished cloth. I leave the difficulties of establishing provenance and other important analyses to my more learned textile historian colleagues.

The Future of Chemical Pest Control

Pickett, John-A.,Woodcock, Christine-M. Korean Society of Applied Entomology 1992 한국응용곤충학회지 Vol.31 No.3

The agricultural industry is beset by continuing demands to decrease the use of pest control agents which employ toxic modes of action. Although there are real problems of pesticide resistance, and sometimes overuse or redistribution in the environment, much criticism results from a lack of appreciation of how small is the risk involved. Whatever the background reasons, research and development for pesticide alternatives, particularly within Integrated Pest Management systems, is clearly of high priority. Currently available approaches, including use of natural products and molecular biology, are often regarded with naive optimism and require critical appraisal. For the future, methods of pest control based on chemicals with non-toxic modes of action (e.g. pheromones) continue to offer promise but, for widespread use, will require their integration with biological agents and development by means of plant molecular biology.

[플로리다 문제] 다가오는 새 시대

MALLORY PICKETT,Zohar Lazar(삽화) 상상스토리(주) 2019 Popular science 한국판 Vol.6 No.-

Electrothermal Coil Detachment Failure in Flow Diverter-Assisted Coiling of a Small Blister Aneurysm: Technical Considerations and Possible Solutions

Gwynedd E. Pickett,Adela Cora 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.2

Flow diversion stenting combined with coiling offers both immediate protection from rebleeding for ruptured aneurysms and long-term stability for wide-necked or blister aneurysms. It is particularly useful for tiny ruptured aneurysms, alleviating the concern that small coils may prolapse between the struts of conventional stents. We employed this technique in a very small, broad-based ruptured aneurysm of the internal carotid, jailing the coiling microcatheter with a Pipeline Embolization Device. However, coil detachment repeatedly failed, until we withdrew the detachment zone into the microcatheter. We suggest that if the tip of the coiling catheter is adjacent to the stent, contact between the junction zone of the coil and the high metal density of the flow diverter may prevent proper electrothermal coil detachment. Detachment can be undertaken successfully within the microcatheter, though care must be taken thereafter to fully push the detached coil tail into the aneurysm.

과도 분무각을 가진 디젤 분무의 액상 및 기상 침투 거리

정용진(Yongjin Jung),Lyle Pickett 한국자동차공학회 2015 한국자동차공학회 부문종합 학술대회 Vol.2015 No.5

Organometalliclike localization of4d-derived spins in an inorganic conducting niobium suboxide

Lee, K.-W.,Pickett, W. E. American Physical Society 2015 Physical review. B, Condensed matter and materials Vol.91 No.19

Time-Lapse Video Microscopy of Wound Recovery and Reproduction in the Siphonous Green Alga Derbesia tenuissima

김광훈,Martin, Erika,Jeremy, Pickett-Heaps,Kim, Gwang-Hoon,West, John 한국조류학회(藻類) 2006 ALGAE Vol.21 No.1

Responses to various types of mechanically induced wounding were followed in the giant-celled Caulerpalean species, Derbesia tenuissima, using time-lapse video-microscopy. Gametophyte vesicle cells. Puncture wounding: the gametophyte cell seals the puncture in 5 min. This is followed by cycles of ruptures and sealing, ending with full recovery in 24 hrs. Cut wounding: the protoplast immediately retracts away from the wall and reforms an intact, deflated protoplast that expands to fill the original cell within 21 hrs. Crush wounding (internal). When retained within the cell wall many protoplast fragments condense, round up, and coalesce; the reconstituted protoplast expands until it attains complete recovery, filling the original cell shape in 12 hrs. Crush wounding (external). Protoplast fragments extruded from the crushed cell are more numerous and smaller taking longer to recover. Most fragments become spherical, transforming into small viable cells capable of reproduction in several days. Sporophyte filaments. Crush wounding creates many small fragments that initially condense, coalesce and then expand within the wall to restore a complete filament with normal cytoplasmic streaming within 5 hrs. Reproduction: gametophyte. Our culture isolates produce more females than males (30:1). Gametangia develop one day before discharge that occurs explosively (1/6 sec) at first morning light. The vesicle cell forms successive gametangia every 14 days. Sporophyte. Each sporangium develops on a lateral branch that becomes isolated by the creation of successive basal plugs. After cytoplasmic cleavage and differentiation the stephanokont spores are discharged. The spores settle quickly and germinate forming gametophyte cells.