Fascin immunoreactivity for preoperatively predicting lymph node metastases in peripheral adenocarcinoma of the lung 3cm or less in diameter

Choi, Phil Jo,Yang, Doo Kyung,Son, Choon Hee,Lee, Kyung Eun,Lee, Jae Ik,Roh, Mee Sook Elsevier 2006 European journal of cardio-thoracic surgery Vol.30 No.3

<P><B>Abstract</B></P><P><B>Objective:</B> Fascin is an actin-bundling protein that induces cell membrane protrusions and increases the motility of normal and transformed epithelial cells. We evaluated the expression of fascin by performing immunohistochemistry to determine its role in the progression of small-size peripheral lung adenocarcinomas and to elucidate its utility as a preoperative novel therapeutic option. <B>Methods:</B> Immunohistochemistry for fascin was performed in 49 peripheral adenocarcinomas of ≤3cm in diameter on the conventional whole tissue (CWT) sections and 2mm-sized tissue microarray (TMA) cores that were the substitute for preoperative biopsy samples. Staining of more than 5% of tumor cells was recorded as positive immunoreactivity. The distribution of fascin labeling was measured according to the percentage of fascin-positive cells: 5–25% (low grade) and >25% (high grade). <B>Results:</B> Overall, fascin immunoreactivity was detected in 30 (61.2%) out of the total 49 cases. The tumors with high-grade fascin immunoreacivity tended to more frequently show lymph node metastasis (<I>P</I>=0.0007), lymphovascular invasion (<I>P</I>=0.0084) and a higher stage (<I>P</I>=0.05). There was no significant association with age, gender, tumor size and the histological subtype. The 2mm-sized TMA cores, which were considered as a substitute for percutaneous needle biopsy sample in this study, showed concordant results with the CWT section (<I>κ</I>=0.836). <B>Conclusions:</B> We suggest that fascin immunoreactivity may identify the subsets of peripheral adenocarcinomas of the lung 3cm or less in diameter that have a different potential to metastasize to the regional lymph nodes. The evaluation of fascin immunoreactivity on the preoperative biopsy sample could be a novel therapeutic strategy for selecting the most appropriate therapy for small-size pulmonary adenocarcinomas.</P>

Dokhwaljihwang-tang inhibits LPS-induced inflammatory cytokine production in peripheral blood mononuclear cells.

Moon, Phil-Dong,Han, Na-Ra,Ko, Seong-Gum,Jeong, Hyun-Ja,Kim, Su-Jin,Lee, Bo-Ra,Kim, Na-Hyung,Choi, In-Young,An, Hyo-Jin,Myung, Noh-Yil,Lee, Hyejung,Kim, Myong-Jo,Kim, Ju-Sung,Hong, Seung-Heon,Kim, Hyu Butterworths [etc.] 2010 Neurological research Vol.32 No.suppl1

<P>OBJECTIVES: Dokhwaljihwang-tang, one of the prescriptions in Four Constitution medicine, has been used to treat neurological disorders. This work was aimed to examine the effect of Dokhwaljihwang-tang on lipopolysaccharide-induced inflammatory cytokine production in peripheral blood mononuclear cells from the lesser yang subjects. METHODS: The inflammatory cytokines, interleukin 1 beta, interleukin 4 and tumor necrosis factor were measured using the ELISA. The interleukin 1 beta mRNA expression was evaluated with reverse transcriptase-polymerase chain reaction. The expression level of nuclear factor kappa B was examined by western blotting. RESULTS: Dokhwaljihwang-tang significantly inhibited interleukin 1 beta and interleukin 4 production (p<0.05). When Dokhwaljihwang-tang was pre-treated at the dose of 1 mg/ml, it not only decreased the interleukin 1 beta mRNA expression, but also inhibited the activation of nuclear factor kappa B. DISCUSSION: These results suggest the potential of Dokhwaljihwang-tang as a source of pharmaceutical acupuncture for neuronal inflammatory diseases.</P>

Novel wearable-type biometric devices based on skin tissue optics with multispectral LED-photodiode matrix

Chang Jo, Young,Kim, Hae Na,Kang, Jae Hwan,Hong, Hyuck Ki,Choi, Yeon Shik,Jung, Suk Won,Kim, Sung Phil IOP Publishing 2017 Japanese journal of applied physics Vol.56 No.4

<P>In this study, we examined the possibility of using a multispectral skin photomatrix (MSP) module as a novel biometric device. The MSP device measures optical patterns of the wrist skin tissue. Optical patterns consist of 2 x 8 photocurrent intensities of photodiode arrays, which are generated by optical transmission and diffuse reflection of photons from LED light sources with variable wavelengths into the wrist skin tissue. Optical patterns detected by the MSP device provide information on both the surface and subsurface characteristics of the human skin tissue. We found that in the 21 subjects we studied, they showed their unique characteristics, as determined using several wavelengths of light. The experimental results show that the best personal identification accuracy can be acquired using a combination of infrared light and yellow light. This novel biometric device, the MSP module, exhibited an excellent false acceptance rate (FAR) of 0.3% and a false rejection rate (FRR) of 0.0%, which are better than those of commercialized biometric devices such as a fingerprint biometric system. From these experimental results, we found that people exhibit unique optical patterns of their inner-wrist skin tissue and this uniqueness could be used for developing novel high-accuracy personal identification devices. (C) 2017 The Japan Society of Applied Physics</P>

여드름 환자의 얼굴에서 피지량, 여드름 병변수, 모공 형광밀도와의 상관 관계

홍승필 ( Seung Phil Hong ),한병관 ( Byung Kwan Han ),정병조 ( Byung Jo Jung ),배영우 ( Young Woo Bae ),최응호 ( Eung Ho Choi ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9

Background: Porphyrins produced by Propionibacterium acnes exhibit an orange-red fluorescence spot on the pilosebaceous pore under UVA light. Based on this characteristic, the recently developed photographic technique, ``fluorescence photography``, warrants mention in the context of acne, especially in the assessment of the presence of bacteria and sebum output. Objective: The aim of this study was to assess the relationship between sebum output and acne lesion counts with fluorescent density (% fluorescence area). We discuss the possibility of the use of fluorescence photography as a new tool to evaluate acne and sebum levels. Methods: Total of 39 subjects, 29 males and 10 females, were recruited for this prospective study. To estimate fluorescent density, fluorescent facial images were taken and analyzed with digital fluorescent imaging system and an image analysis program. The sebum output level was measured with a Sebumeter(R). Numbers of acne lesions were counted. Also, sebum output and fluorescent images were compared before and after the use of a facial cleanser containing 1% triclosan. Results: Sebum output level was significantly associated with fluorescent density, but not with the number of acne lesions. However, in the group using triclosan containing cleanser, fluorescent density decreased, while sebum level increased. Therefore, fluorescent density seems to be influenced mainly by the density of P. acnes. Conclusion: Fluorescence density correlates with P. acnes mostly followed by sebum output level. Digital fluorescent imaging system is considered as a useful tool to assess sebum excretion as well as colonization of P. acnes. (Korean J Dermatol 2007;45(9):890∼897)

A study on the key performance indicator of the dynamic positioning system

Park, Kwang-Phil,Jo, A-Ra,Choi, Jin-Woo The Society of Naval Architects of Korea 2016 International Journal of Naval Architecture and Oc Vol.8 No.5

The dynamic positioning system (DPS) maintains an offshore vessel's position and heading under various environmental conditions by using its own thrust. DPS is regarded as one of the most important systems in offshore vessels. So, efficient operation and maintenance of the DPS are important issues. To monitor the DPS, it is necessary to define an appropriate key performance indicator (KPI) that can express the condition of the DPS from the perspective of operational efficiency and maintenance. In this study, a new KPI for the DPS is proposed considering the efficiency of the machinery and controller, the energy efficiency, and the environmental conditions in which the DPS is operated. The KPI is defined as a function of control deviation, energy consumption, and environmental load. A normalization factor is used to normalize the effect of environmental load on the KPI. The KPI value is calculated from DPS simulation and model test data. The possibility of applying the KPI to monitoring of DPS condition is discussed by comparing the values. The result indicates the feasibility of the new KPI.

식도암의 근치적 식도 절제술 후 폐합병증의 발생에 영향을 미치는 위험인자의 임상적 분석

최필조,정상석,Choi, Phil Jo,Jeong, Sang Seok 대한기관식도과학회 2011 大韓氣管食道科學會誌 Vol.17 No.2

Purpose Pulmonary complications continue to be the major cause of morbidity and mortality after esophageal resection. The aim of this study was to compare and analyze retrospectively the factors which effect for postoperative pulmonary complications in patients who underwent curative resection for esophageal cancer. Material and Method A total of 118 patients were enrolled in the study from January 1994 to March 2009, and patients with previous neoadjuvant chemotherapy or radiotherapy were excluded. Of the total 118 patients, 27 patients developed pulmonary complications within 30 days of their operation. the factors which effect for postoperative pulmonary complications were compared and analyzed. Results There were 7 patients in-hospital deaths. 51 patients (43.2%) developed complications, and of them, the most common complication was pulmonary complication and occurred in 27 patients (22.9%). In univariate analysis, diabetes mellitus, cervical anastomosis through the retrosternal route, old age and poor lung function were risk factors contributing to postoperative pulmonary complications (p<0.05). In multivariate analysis, statistically significant factor was old age (65 years or older). Conclusion Clinical factor for the pulmonary complications after esophagectomy of esophageal cancer was significantly associated with diabetes mellitus, cervical anastomosis through the retrosternal route, old age (65 years or older) and poor lung function (FEV1<80%). Of these, old age was the most significant factor.

Ag nanoparticles-embedded surface plasmonic InGaN-based solar cells via scattering and localized field enhancement

Shim, Jae-Phil,Choi, Sang-Bae,Kong, Duk-Jo,Seo, Dong-Ju,Kim, Hyung-jun,Lee, Dong-Seon The Optical Society 2016 Optics express Vol.24 No.14

기상측정시스템과 오차보정을 이용한 가공정밀도 향상

최진필(Jin-Phil Choi),민병권(Byung-Kwon Min),이상조(Sang-Jo Lee) Korean Society for Precision Engineering 2003 한국정밀공학회지 Vol.20 No.12

경부 원발부불명 전이성 암의 치료 결과

팽재필(Jae Phil Paeng),조성동(Seong Dong Jo),임기정(Ki Jung Lim),김은중(Eun Joong Kim),박지훈(Ji Hoon Park),권순영(Soon Young Kwon),최종욱(Jong Ouck Choi),정광윤(Kwang Yoon Jung) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2

Background: Cervical metastasis of unknown origin is defined as histologic evidence of malignancy in the cervical lymph nodes with no apparent primary site of origin for the metastatic tumor. Patients and Methods: A retrospective review of 20 cervical metastasis of unknown origin diagnosed and managed between january 1989 and December 1999 at the Korea University was undertaken to determine outcome. Patient age ranged 46 to 78 years (mean 60). There were 17 men and 3 women. The aim of this study is to ananlyze the diagnostic approach and the result of treatment of the cervical metastasis of unknown origin. Result: Histopathologically, squamous cell carcinoma (15 case, 75%) were the most common, followed by adenocarcinoma (4 case, 20%), undifferentiated carcinoma (1 case, 5%) According to the criteria of the AJCC on staging, N1 was 2 cases, N2a 2 cases, N2b 5 cases, N2c 1 cases, N3 10 cases. Overall survival rate for all patients at 2 years was 45% and 5 years 25%, and in the combination therapy(surgery and radiotherapy group (12 cases)) it was 67% and 34% respectively, high compared with other treatment modality such as surgery or radiotherapy alone. In extracapsular spread positive group, 5 year survival rate was 12%, but was 33% in the extracapsular spread negative group. Conclusion: With no stastatical significance, extracapsular spread group was poor outcome in our study. Combination of radiotherapy and surgery was more effective treatment result than surgery alone or radiotherapy alone in our study. But, overall prognosis of cervical metastasis of unknown origin was very poor despite aggressive treatment (5 year survival rate: 25%).

급성 췌장염의 임상적 고찰

유병대,조준,박찬상,안영호,최우익,이동필 대한응급학회 1998 대한응급의학회지 Vol.9 No.2

This study was designed retrospectively to evaluate Ranson's criteria and APACHE Ⅱ score as a predictor of mortality in patients with acute pancreatitis. Acute pancreatitis is a common disorder. From mild disease to multiorgan failure, it is a disorder that has numerous causes, an obscure pathogenesis. An accurate history and through physical examination will often raise clinical suspicion of acute pancreatitis in the differential diagnosis of a patient with acute abdominal pain. The retrospective analysis by chart review of 86 cases of acute pancreatitis who visited emergency department of Dongsan hospital from Jan to Dec 1996. The results were as follows. The majority of the patients with acute pancreatitis presented with chief complaints of abdominal pain. The male patient outnumbered female by the ratio of 2.9:1. The highest incidence of age group was between 40 and 50. The majority of our patients had past histories of either chronic alcoholic or gallbladder problems e.g.. the number being 53 cases(61.6%) and 31 cases(36%) respectively. Among 7 patients who had changes in consciousness, 5 were expired. Of those expired, 3 patients had less than 90 mmHg of systolic blood pressure. The overall mortality rate was 10.5%(9 cases). It has been known that acute pancreatitis would be the results of traumatic and non-traumatic causes. The exact mechanism of its pathophysiolgy has not been known yet, but it has been well known that the majority of patients who in forties and fifties had history of alcoholic abuse, the rest being mainly gallbladder problem and, some other diseases implicated too. The relationship of acute pancreatitis with familiar Ranson's criteria was such that 3 patients of the Ranson's out of 9 death were noted to have more than 3 of the criteria, but another 3 had less than 3. Among the 60 patients in whom the required physiologic variables were available out of total 86 patients studied, 9 were expired and 51 survived, average APACHE Ⅱ scores for the survival and the expired being 6.92±3.99 & 18.11±5.68 respectively (p<0.05). We concluded that the APACHE Ⅱ score could be used to better than Ranson's criteria to predict hospital mortality in patients with acute pancreatitis.