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Two new sesquiterpenoids from endophytic fungus J3 isolated from Mangrove Plant Ceriops tagal
Yan-Bo Zeng,Hai-Gang Gu,Wen-Jian Zuo,Li-Li Zhang,Hong-Jin Bai,Zhi-Kai Guo,Peter Proksch,Wen Li Mei,Hao Fu Dai 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Two new sesquiterpenoids, named 2a-hydroxyxylaranolB (1) and 4b-hydroxyxylaranol B (2), togetherwith a known diterpenoid 3,4-seco-sonderianol (3) wereisolated from the fermentation of endophytic fungus J3 ofCeriops tagal. Their structures were elucidated based onspectroscopic methods including 1D and 2D NMR(HMQC, 1H-1H COSY and HMBC). All compounds wereevaluated for their cytotoxic activities by MTT method,and compound 3 exhibited cytotoxic activities againstK562, SGC-7901, and BEL-7402 cell lines.
Protein Kinase and HDAC Inhibitors from the Endophytic Fungus <i>Epicoccum nigrum</i>
El Amrani, Mustapha,Lai, Daowan,Debbab, Abdessamad,Aly, Amal H.,Siems, Karsten,Seidel, Carole,Schnekenburger, Michael,Gaigneaux, Anthoula,Diederich, Marc,Feger, Daniel,Lin, Wenhan,Proksch, Peter American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.1
<P>A chemical investigation of the endophytic fungus <I>Epicoccum nigrum</I> isolated from leaves of <I>Mentha suaveolens</I> collected in Morocco resulted in the isolation of five new polyketides, epicocconigrones A and B (<B>1</B> and <B>2</B>), 3-methoxyepicoccone B (<B>3</B>), 3-methoxyepicoccone (<B>4</B>), and 2,3,4-trihydroxy-6-(methoxymethyl)-5-methylbenzaldehyde (<B>5</B>), together with five known compounds (<B>6</B>–<B>10</B>). The structures of the new compounds were unambiguously determined by extensive analysis of the 1D and 2D NMR and mass spectroscopic data. Compounds <B>1</B> and <B>10</B> showed potent inhibition of at least 15 protein kinases with IC<SUB>50</SUB> values ranging from 0.07 to 9.00 μM. Moreover, compounds <B>1</B> and <B>10</B> inhibited histone deacetylase (HDAC) activities with IC<SUB>50</SUB> values of 9.8 and 14.2 μM, respectively. A preliminary structure–activity relationship is discussed. Interestingly, compounds <B>1</B> and <B>10</B> exert mainly cytostatic effects in human lymphoma RAJI and U-937 cell lines.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-1/np4005745/production/images/medium/np-2013-005745_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np4005745'>ACS Electronic Supporting Info</A></P>
Meng-Meng Lv,Ming-Hui Tan,Li-Wen Lu,Rong-Hua Zhang,Zhi-Yong Guo,Cheng-Xiong Liu,Jin Yang,Kun Zou,Peter Proksch 한국생약학회 2018 Natural Product Sciences Vol.24 No.3
Two new polyketides, chinoketides A and B (1 - 2) with a known compound xylarphthalide A (3), were isolated from the solid medium of the endophytes from the leaves of the relic plant Distylium chinense with the "black-box" co-culture method, and the structures of two new compounds were elucidated by NMR, MS and CD spectra. And the absolute configurations of chinoketides A (1) and B (2) were determined as 2R,3R,8S and 5R,6S by calculating their ECD spectra to compare with the experimental CD spectra. Finally, the antimicrobial activities were evaluated to Erwinia carotovora sub sp. Carotovora (Jones) Bersey et al, and the results showed that compounds 1 - 3 displayed the antimicrobial activities with MIC value at 20.5, 30.4 and 10.2 mg/mL.