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SangMi Han,KwangGill Lee,JooHong Yeo,SoonOk Woo,HaeYong Kweon,YouYoung Jo,Peter Molan 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05
Since the ancient times the therapeutic application of honeybee venom (BV) is practised and persisted until the present days. Resistant bacteria are in emergence and some drugs no longer have an antimicrobial action. To purify the melittin known as antibacterial peptide, five major peptidergic subfractions were separated, purified and identified from the whole BV. We investigated the antibacterial activity of whole BV and purified melittin against Staphylococcus aureus by the minimum inhibitory concentrations (MIC) and the postantibiotic effect (PAE). The MIC of whole BV for S. aureus was 0.06 ㎍/㎖, respectively. The MIC of melittin was 0.06 ㎍/㎖ on S. aureus. The in vitro PAE of whole BV and isolated melittin were determined using E. coli and S. aureus. The PAE of whole BV against S. aureus were 3.45 h (1×MIC). The PAE of melittin against S. aureus was 4.35 h (1 × MIC). Also both whole BV and melittin killed S. aureus at 5 × MIC. The regrowth wasn't observed after 18 h. These results suggest that whole BV and melittin will be developed a novel antibacterial drug.
Staphylococcus aureus에 대한 국내산 꿀벌독의 항균성분 분리
한상미(Sangmi Han),이광길(Kwanggill Lee),여주홍(Joohong Yeo),권해용(Haeyong Kweon),우순옥(Soonok Woo),백하주(Haju Baek),장영채(Youngchae Chang),박관규(Kwankyu Park),Peter Molan 한국양봉학회 2008 韓國養蜂學會誌 Vol.23 No.2
Pure honeybee venom collected from Korea has been extensively used in livestock and folk medicines for a natural antibacterial agent. In the present study, we isolated and purified a novel antibacterial peptide fraction against Staphylococcus aureus from honeybee venom by liquid chromatography and mass spectrometry. The average molecular mass of the peptide was estimated to be 895.4 Da. The antibacterial activity of the peptide was evaluated in terms of Minimal inhibitory concentration. Minimal inhibitory concentration value was about 0.1μg/ml. The peptide can be considered as a potential compound for the development of new natural antibacterial agents for use in livestock and human.