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Tianbo Lu,Jiaxi Lin,Lingling Zhao,Yang Li,Yong Peng 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.7
Governments, companies, universities and research institutes are pushing the research and development of cyber-physical systems (CPS). However, the development of cyber-physical systems is constrained by security factors. According to this situation, this paper put forward a CPS security model, which contains security objectives, basic theories, simulation, and CPS framework, summarizes security attacks to cyber-physical systems as a theoretical reference for the study of cyber–physical systems and to provide useful security defense. Based on the cyber-physical systems framework, the paper classifies attacks for the execution layer, transport layer and control layer. The execution layer attacks include security attacks for nodes such as sensors and actuators. Transport layer attacks include data leakage or damage and security issues during massive data integration. Control layer attacks include the loss of user privacy, incorrect access control policies and inadequate security standards. This paper gives security defenses and recommendations for all types of security attacks. Finally, this paper introduces categorizations of CPS application fields and explores their relationships.
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IDO promotes the proliferation and invasion of prostate cancer cells through KYNU
Zhou Hongqing,Wang Wei,Liu Mingsheng,Xie Pingbo,Deng Tibin,Peng Jiaxi,Xu Chenxiang 한국유전학회 2023 Genes & Genomics Vol.45 No.3
Background Prostate cancer (PCa) is one of the most common malignant tumors in male. Objective To explore the effect of indoleamine-2, 3-dioxygenase (IDO) on the proliferation and invasion of PCa cells and the potential mechanism. Methods PCa tissues and normal adjacent tissues were collected from 43 PCa patients. The expression of IDO in PCa tissues and cell lines were detected. The String website was used to search for IDO-related proteins. The GEPIA website was used to analyze the relationship between KYNU and the prognosis of PCa. Cells models of IDO overexpression and/or KYNU silencing were constructed to verify the role of KYNU in regulating PCa. The cell proliferation, apoptosis and invasion ability of PCa cells were detected by CCK-8 assay, Flow cytometry and Transwell assay. Results The IDO levels in PCa tissues and cells were higher than those in normal tissues and cells, which promoted the proliferation and invasion of LNCaP cells, and inhibited apoptosis. Silencing IDO inhibited the cells proliferation and invasion activities, and promoted the cell apoptosis. The high expression of KYNU was related to the poor disease free survival of PCa patients. Inhibiting KYUN significantly inhibited the promotion of PCa induced by IDO. Conclusion IDO is overexpressed in PCa, which promotes the proliferation and invasion of PCa cells, and the cancer-promoting mechanism may be related to KYNU.
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