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담마진과 아토피 피부염에 대한 Astemizole의 치료 효과에 관한 연구 : 공동연구 Multicenter Trials
김명남,노병인,김상원,박석돈,박진주,김석호 대한화학요법학회 1986 대한화학요법학회지 Vol.4 No.1
Authors performed a clinical study to evalute the therapeutic effect of Astemizole on urticaria and atopic dermatitis. Totally 88patients including 66 urticaria patients(acute urticaria, 16; chronic urticaria, 23; factitious urticaria, 27) and 22 atopic dermatitis patients were studied by oral administration of 10 ㎎ Astemizole tablet daily for 6 weeks. The estimation of therapeutic effect was done by the measurement of duration until disappearance of symptoms(erythema, wheal and pruritus in acute and chronic urticaria; pruritus and dermographism in factitious urticaria; pruitus in atopic dermatitis). The results were as follows: 1. Acute urticaria; The percentage of patients who showed therapeutic effect was 81.2%(excellent, 31.2% ; good, 37.5% ; fair, 12.5%). This was statistically significant in difference vs poor(p<0.01). 2. Chronic urticaria; The percentage of patients who showed therapeutic effect was 87.0%(excellent, 34.8% ; good, 43.5% ; fair , 8.7%). This was statistically significant in difference vs poor(p<0.01). 3. Factitious urticaria; The percentage of patients who showed therapeutic effect was 85.2%(excellent, 33.3% ; good, 40.7% ; fair, 11.2%). This was statistically significant in difference vs poor(p<0.01). 4. Atopic dermatitis; The percentage of patients who showed therapeutics effect was 81.8%(excellent, 36.4% ; good, 409% ; fair,4.5%). This was statistically significant in difference vs poor(p<0.01). 5. During the study, 11 patients observed side effects(sedation, 5; dry mouth, 4; gastric discomfort, 2). Therefore we have impressed that Astemizole is an effective antihistamine which develop less side effects than other antihistamines for urticaria and atopic dermatitis.
아토피 피부염에서 말초 혈액내 호산구 수, 혈청 총 IgE, eosinophil cationic protein, IL-4 및 soluble E-selectin의 변화
김명남 ( Myeung Nam Kim ),신봉주 ( Bong Ju Shin ),탁우정 ( Woo Jung Tak ),노병인 ( Byung In Ro ),박애자 ( Ae Ja Park ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11
N/A Background : Since the management of atopic dermatitis often needs rolonged administration of medication, the laboratory index reflecting disease severity is necessary for optimal treatment for this disease. Objectives : The purpose of this study is to evaluate peripheral eosinophil counts, serum total IgE, eosinophilic cationic protein(ECP), IL-4 and soluble E-selectin as severity indices or disease marker. Method : A total of 21 patients with atopic dermatitis and 21 normal controls were evaluated for the symptoms and signs according to SCORAD index and measured for peripheral eosinophil counts, serum total IgE, ECP, IL-4 and soluble E-selectin. Results : Peripheral eosinophil counts, serum total IgE, ECP and soluble E-selectin levels of patients with atopic dermatitis were significantly increased compared with those of normal control(p<0.05). Moreover, serum ECP and soluble E-selectin correlated with SCORAD score. Serum IL-4 levels of patients with atopic dermatitis were slightly increased compared with those of normal control but not statistically significant(p>0.05). Conclusion : ECP and soluble E-selectin were good serum marker reflecting the severity of atopic dermatitis.
( Kui Young Park ),( Woo Sun Jang ),( In Pyeong Son ),( Sun Young Choi ),( Moo Yeol Lee ),( Beom Joon Kim ),( Myeung Nam Kim ),( Byung In Ro ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.1
Background: Alopecia areata (AA) is believed to be an organ-specific autoimmune disease in which a mononuclear cell infiltrate develops in and around anagen hair follicles. There is no definitive therapy for AA. Objective: We sought to determine whether the combination therapy of cyclosporine and psoralen plus ultraviolet A (PUVA) could be an effective treatment for severe AA. Methods: A total of 41 patients with severe AA were treated with oral cyclosporine and topical PUVA. Cyclosporine was given at an initial daily dose of 200 mg for adult and 100 mg for children for periods of up to 16 weeks. Eight-methoxypsoralen (Methoxsalen) was applied topically 20 minutes prior to ultraviolet A (UVA) exposure, and the patients were irradiated with UVA twice a week for 16 weeks. Results: Of the total 41 patients, 2 (7.3%) patients were lost to follow-up, and 1 (2.4%) patient discontinued the treatment due to abdominal discomfort. Six (14.6%) patients were treated for less than 12 weeks. Of remaining 32 patients, 3 (9.4%) showed excellent response, 3 (9.4%) showed good response, 12 (37.5%) showed fair response, and 14 (43.7%) showed poor response. Conclusion: Although limited by its uncontrolled character, this study shows that the combination therapy with cyclosporine and PUVA may be an additional choice for severe and recalcitrant AA. (Ann Dermatol 25(1) 12∼16, 2013)
( Mi Youn Park ),( Kyung Ho Kim ),( Hoon Kang ),( Young Chul Kye ),( Hyuck Hoon Kwon ),( Kwang Joong Kim ),( Nack In Kim ),( Myeung Nam Kim ),( Young Suck Ro ),( Seong Uk Min ),( Kui Young Park ),( Ma 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Despite the prevalence of acne is increasing gradually in the population of Korea, relatively little is known about its epidemiology. Also the incidence of childhood acne is unknown. Objectives: Investigation about the number and distribution of acne according to age group by analyzing epidemiological data from several general hospitals in Korea. Methods: Retrospective multi-center study of patients who are diagnosed with acne vulgaris through department of dermatology in Korea. Results: 1. Acne patients have been increased by 60% in number compared to 10 years ago. The number of childhood acne also increased 10-15% annually during the recent 4 years and the number of patients with age under 19 has been doubled during 10 years. 2. Age under 12 accounted for 11% of total acne patients and showed 20% increase in number during 4 years. Although upper grade of elementary school patients (age 10-12) have biggest portion among the patients under 12, the number of patients under the age of 9 has been also increased rapidly by 73% compared to 10 years ago. Conclusion: This was the first large scale, multi-center study and analysis done in Korea including 14 general hospitals with maximum 10 years of long term follow-up. We could find out that acne patients are increasing consistently and the proportion of group under 19 is getting larger. Additionally onset age of acne is getting younger. So it is important to raise the public awareness of childhood acne for early management
소에서 Detomidine 투여에 의한 진정효과 및 혈액성분의 변화
박명호,남치주,권오경,Park Myeung-Ro,Nam Tchi-Chou,Kweon Oh-Kyeong 한국임상수의학회 1989 한국임상수의학회지 Vol.6 No.1
In order to investigate sedative action of detomidine and its effect on physical signs, hematological and blood chemical components, 15 Holstein cattle were used. The dosage of detomidine was 25 ${\mu}$g/kg and 50 ${\mu}$g/kg. Blood was collected before injection, 30, 60 and 120 min. after injection. Induction time of sedation in a cattle given with 25 ${\mu}$g/kg and 50 ${\mu}$g/kg of detomidine was 10.6${\pm}$2.8. 7.6${\pm}$1.0min. respectively and maintenance time was 70.4${\pm}$8.3, 86.5${\pm}$9.9, respectively. After injection of detomidine, body temperature was slightly increased, heart rate and respiratory rate were slightly decreased. The levels of red blood cell, hemoglobin, packed cell volume and white blood cell were not changed by detomidine. Blood glucose level following detomidine was markedly increased but total protein, serum glutamic oxaloacetic transminase, alkaline phosphatase, lactic dehydrogenase, blood urea nitrogen and creatinine were not changed. This results indicated that detomidine was useful sedative in bovine practice.
아토피피부염 학회보고서: 한국인 아토피피부염의 진단기준에 대한 연구
박영립 ( Young Lip Park ),김형동 ( Hyung Dong Kim ),김규한 ( Kyu Han Kim ),김명남 ( Myeung Nam Kim ),김진우 ( Jin Wou Kim ),노영석 ( Young Suck Ro ),박천욱 ( Chun Wook Park ),이광훈 ( Kwang Hoon Lee ),이애영 ( Ai Young Lee ),조상 대한피부과학회 2006 대한피부과학회지 Vol.44 No.6
Background: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with genetic and environmental background. The diagnosis of AD depends on the clinical presentation and history because there are no objective laboratory tests. The criteria established by Hanifin and Rajka have become the standard for the clinical diagnosis of AD (Until now, we used conventional Hanifin and Rajka`s diagnostic guidelines). But diagnostic criteria for Korean have not been studied yet. Objective: The purpose of the present study was to establish the diagnostic criteria of Korean AD. Methods: We made out a draft for diagnostic criteria for Korean on the basis of the Hanifin and Rajka`s guidelines and published Korean journals. And we established the diagnostic criteria for Korean after collecting extensive opinions from dermatologic specialists in many university hospitals. Results: The major criteria of AD is similar to conventional diagnosic criteria, but three additional minor features(periauricular eczema, scalp scale, skin prick test reactivity) were significant for the diagnosis of AD in Korean patients. The other eleven minor features of the conventional minor diagnostic features were also significant. Conclusion: We established Korean diagnostic criteria for AD. Our result suggest that ethnic backgrounds influence the phenotype of AD and that additional three features need to be included in the Korean diagnostic criteria. Continued refinement of these guidelines will facilitate diagnosis in specific ethnic populations and in specific subgroups of patients. (Korean J Dermatol 2006;44(6):659~663)
아토피피부염 환자에서 국소 피메크로리무스의 효과와 순응도에 관한 다기관 설문조사
김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),김규한 ( Kyu Han Kim ),김도원 ( Do Won Kim ),노영석 ( Young Suck Ro ),박천욱 ( Chun Wook Park ),이승철 ( Seung Chul Lee ),이애영 ( Ai Young Lee ),최지호 ( Jee Ho Choi ),이광훈 ( K 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Background: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that`s influenced by many genetic and environmental factors. Various treatment modalities are being applied for AD, including phototherapy, topical applicants and systemic agents. However, there has been no mass survey in Korea concerning the compliance of patients` to use their prescribed medication, which might influence the clinical efficacy of the physicians` treatment. Objective: The purpose of the present study is to evaluate the efficacy, safety and patient compliance with using topical pimecrolimus to treat AD. Methods: We reviewed the medical recordings, laboratory profiles, clinical severity scoring and photographs of AD patients at 9 general hospitals in Seoul and the local area of Korea. Interviews with the patients and a telephone survey were also done. Those patients who weren`t perscribed topical applicants or those who did not use topical pimecrolimus or steroid within 6 months were excluded from this study. Results: Topical pimecrolimus cream effectively controlled AD with a reduction of the EASI score from baseline 13.75 to 11.39 at 2 weeks and 4.46 at 10 weeks of topical pimecrolimus application. When topical pimecrolimus cream was applied for more than 12 months it significantly suppressed the recurrence and reactivation of AD (p<0.05). Although 22.6% of the patients complained of adverse effects, these were all transient and they did not evoke significant medical problems. Using topical pimecrolimus cream did not show significant adverse effects or complications. Conclusion: Topical pimecrolimus might well be an effective treatment modality for treating AD when patients show good compliance for applying the cream. (Korean J Dermatol 2008;46(10):1357∼1361)