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Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior
Park, Sunho,Park, Hyun-Ha,Sun, Kahyun,Gwon, Yonghyun,Seong, Minho,Kim, Sujin,Park, Tae-Eun,Hyun, Hoon,Choung, Yun-Hoon,Kim, Jangho,Jeong, Hoon Eui American Chemical Society 2019 ACS NANO Vol.13 No.10
<P>Vertically aligned nanomaterials, such as nanowires and nanoneedles, hold strong potential as efficient platforms onto which living cells or tissues can be interfaced for use in advanced biomedical applications. However, their rigid mechanical properties and complex fabrication processes hinder their integration onto flexible, tissue-adaptable, and large-area patch-type scaffolds, limiting their practical applications. In this study, we present a highly flexible patch that possesses a spiky hydrogel nanostructure array as a transplantable platform for enhancing the growth and differentiation of stem cells and efficiently suppressing biofilm formation. <I>In vitro</I> studies show that the hydrogel nanospike patch imposes a strong physical stimulus to the membranes of stem cells and enhances their osteogenic, chondrogenic, and adipogenic differentiation and the secretion of crucial soluble factors without altering cell viability. At the same time, the array exhibits effective bactericidal properties against Gram-positive and Gram-negative bacteria. <I>In vivo</I> studies further demonstrate that the flexible hydrogel patch with its spiky vertical nanostructures significantly promotes the regeneration of damaged cranial bone tissues while suppressing pathogenic bacterial infections in mouse models.</P> [FIG OMISSION]</BR>
Park Chan,Kim Jin Hyoung,Kim Pyeong Hwa,Kim So Yeon,Gwon Dong Il,Chu Hee Ho,Park Minho,Hur Joonho,Kim Jin Young,Kim Dong Joon 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.2
Objective: Clinical outcomes of patients who undergo transarterial chemoembolization (TACE) for single small hepatocellular carcinoma (HCC) are not consistent, and may differ based on certain imaging findings. This retrospective study was aimed at determining the efficacy of pre-TACE CT or MR imaging findings in predicting survival outcomes in patients with small HCC upon being treated with TACE. Besides, the study proposed to build a risk prediction model for these patients. Materials and Methods: Altogether, 750 patients with functionally good hepatic reserve who received TACE as the first-line treatment for single small HCC between 2004 and 2014 were included in the study. These patients were randomly assigned into training (n = 525) and validation (n = 225) sets. Results: According to the results of a multivariable Cox analysis, three pre-TACE imaging findings (tumor margin, tumor location, enhancement pattern) and two clinical factors (age, serum albumin level) were selected and scored to create predictive models for overall, local tumor progression (LTP)-free, and progression-free survival in the training set. The median overall survival time in the validation set were 137.5 months, 76.1 months, and 44.0 months for low-, intermediate-, and high-risk groups, respectively (p < 0.001). Time-dependent receiver operating characteristic curves of the predictive models for overall, LTP-free, and progression-free survival applied to the validation cohort showed acceptable areas under the curve values (0.734, 0.802, and 0.775 for overall survival; 0.738, 0.789, and 0.791 for LTP-free survival; and 0.671, 0.733, and 0.694 for progression-free survival at 3, 5, and 10 years, respectively). Conclusion: Pre-TACE CT or MR imaging findings could predict survival outcomes in patients with small HCC upon treatment with TACE. Our predictive models including three imaging predictors could be helpful in prognostication, identification, and selection of suitable candidates for TACE in patients with single small HCC.
An Analytical Electroabsorption Modulator Model for Radio-over-Fiber Links with Dispersive Channel
Minho Park,Ju-Hang Sohn 한국정보통신학회 2018 2016 INTERNATIONAL CONFERENCE Vol.10 No.1
The electroabsorption modulator (EAM) is one of dominant factors for system performance from its nonlinearity. In this paper, the EAM was modeled for RoF link analysis. Additionally, the EAM output is modeled by harmonics using mathematical expressions.
Bias Compensated Least Mean Mixed-norm Adaptive Filtering Algorithm Robust to Impulsive Noises
Minho Lee,In Seok Park,Chan-eun Park,Hosub Lee,PooGyeon Park 제어로봇시스템학회 2020 제어로봇시스템학회 국제학술대회 논문집 Vol.2020 No.10
This paper proposes the bias-compensated normalized least mean mixed-norm (BC-LMMN) algorithm robust to the impulsive noises. This algorithm is derived from the cost function that uses mixed-norm of the l₂ norm and l₄ norm, where a mixing parameter is used to combine them. To reduce the bad effects of impulsive noises, two methods step-size scaler (SSS) and modified Huber function (MHF) are utilized. The SSS is derived from the modified log type cost function and is applied to the proposed algorithm to make the algorithm robust against the impulsive noises. MHF is a piece-wise linear function and effective in the impulsive noise environment. An unbiasedness criterion is adopted to eliminate the bias caused by the input noises and derive the bias compensation vector. Simulation results show that the proposed algorithm outperforms the traditional algorithms in the aspect of the convergence rate and the steady-state misalignment.
Generation and Transmission of a Quasi-Optical Single Sideband Signal for Radio-Over-Fiber Systems
Minho Park,Kyu-Cheol Kim,Jong-In Song IEEE 2011 Photonics Technology Letters Vol.23 No.6
<P>Generation of a quasi-optical single sideband (OSSB) signal for a radio-over-fiber system utilizing the coherent population oscillation effects in a nonlinear semiconductor optical amplifier and transmission over a single-mode fiber (SMF) are investigated. The quasi-OSSB signal generator consists of an electroabsorption modulator and a nonlinear semiconductor optical amplifier. Characteristics of generated quasi-OSSB signals having different radio-frequency (RF) waves (1-50 GHz) transmitted over SMFs of different lengths (4-21 km) were investigated. Bit-error-rate performance of quasi-OSSB signals having 155-Mb/s differential phase-shift keying (DPSK) data transmitted over 0- to 55-km-long SMFs was also evaluated.</P>