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Ankyrin Repeat-Rich Membrane Spanning/Kidins220 Protein Interacts with Mammalian Septin 5
Park, Han-Jeong,Park, Hwan-Woo,Lee, Shin-Jae,Arevalo, Juan Carlos,Park, Young-Seok,Lee, Seung-Pyo,Paik, Ki-Suk,Chao, Moses V.,Chang, Mi-Sook Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.2
Neurotrophin receptors utilize specific adaptor proteins to activate signaling pathways involved in various neuronal functions, such as neurite outgrowth and cytoskeletal remodeling. The Ankyrin-Repeat Rich Membrane Spanning (ARMS)/kinase D-interacting substrate-220 kDa (Kidins220) serves as a unique downstream adaptor protein of Trk receptor tyrosine kinases. To gain insight into the role of ARMS/Kidins220, a yeast two-hybrid screen of a rat dorsal root ganglion library was performed using the C-terminal region of ARMS/Kidins220 as bait. The screen identified a mammalian septin, Septin 5 (Sept5), as an interacting protein. Co-immunoprecipitation using lysates from transiently transfected HEK-293 cells revealed the specific interaction between ARMS/Kidins220 and Sept5. Endogenous ARMS/Kidins220 and Sept5 proteins were colocalized in primary hippocampal neurons and were also predominantly expressed at the plasma membrane and in the tips of growing neurites in nerve growth factor-treated PC12 cells. Mapping of Sept5 domains important for ARMS/Kidins220 binding revealed a highly conserved N-terminal region of Sept5. The direct interaction between ARMS/Kidins220 and Sept5 suggests a possible role of RMS/Kidins220 as a functional link between neurotrophin receptors and septins to mediate neurotrophin-induced intracellular signaling events, such as neurite outgrowth and cytoskeletal remodeling.
박준성,강준구,이재형,김종표,이창범,박용수,김동선,최웅환,김태화,손장원,최정혜,박충기,박용욱,안유헌 한양대학교 의과대학 2002 한양의대 학술지 Vol.22 No.2
Although autopsy studies indicated metastatic thyroid invlovement in up to 24 % of patient who die of disseminated carcinoma, it has not been reported that adenoid cystic carcinoma spread to the thyroid gland. Because metastases to the thyroid gland are not detected in clinical practices in most case and their primary sites and histologic subtype are not easily identifiable, the prognosis is poor when metastatic cancer to the thyroid gland occurs. In any patient who has the history of previous malignancy, the evidence of weight loss and bulging mass on anterior neck, a new thyroid mass should be considered malignancy until proved otherwise by FNA biopsy. We experienced the case of a patient presented with increasing dyspnea disguised as asthma apparently due to adenoid cystic carcinoma metastasized to the thyroid gland, which caused fixed obstruction. We present this case with a review of literatures.
Acute and genetic toxicity of GS-E3D, a new pectin lyase-modified red ginseng extract
Park, Cho Rong,Pyo, Mi Kyung,Lee, Hwan,Hong, Seung Young,Kim, Su Hwan,Park, Cheol Beom,Oh, Seung Min Elsevier 2019 Regulatory toxicology and pharmacology Vol.104 No.-
<P><B>Abstract</B></P> <P>Korean red ginseng and its extract have been used as traditional medicines and functional foods in countries worldwide. Pectin lyase-modified red ginseng extract (GS-E3D) was newly developed as a dietary supplement for obesity, diabetes-related renal dysfunction, etc. In this study, the safety of GS-E3D on acute toxicity and genotoxicity was evaluated. For acute study, Sprague-Dawley rats were administrated by oral gavage at a dose of 5000 mg/kg GS-E3D. To evaluate genotoxicity of GS-E3D, we conducted three-battery tests, which are Ames test using <I>Escherichia coli</I> (WP2<I>uvrA</I> pKM101) and <I>Salmonella typhimurium</I> strains (TA98, TA100, TA1535 and TA1537), chromosomal aberration test -using Chinese hamster lung cells, and micronucleus test using ICR mice. In acute toxicity studies, there were no dead animals or abnormal necropsy findings in the control group and GS-E3D (5000 mg/kg) treated group. GS-E3D did not induce mutagenicity in the bacterial test, chromosomal aberrations in Chinese hamster lung cells and micronuclei in bone marrow cells of mice. Conclusively, the approximate lethal dose of GS-E3D was greater than 5000 mg/kg bw and GS-E3D has no genotoxic potential in the three-battery tests on genotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Safety studies of acute toxicity and genotoxicity of pectin lyase-modified red ginseng extract were conducted. </LI> <LI> The approximate lethal dose of GS-E3D was greater than 5000 mg/kg bw in male and female SD rats. </LI> <LI> Bacterial reverse mutation test, <I>in vitro</I> CA assay, and <I>in vivo</I> MN test were used as three battery tests on genotoxicity. </LI> <LI> GS-E3D has no genotoxic potentials in three battery tests on genotoxicity. </LI> </UL> </P>
Hwan Myung Lee,Hyo Jin Kim,Hyo-Jun Park,Kyung-Jong Won,Junghwan Kim,신화섭,Pyo-Jam Park,Hyun-Jun Kim,Kyung-Yung Lee,Seung Hwa Park,Chang-Kwon Lee,김보경 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
Tyrosine kinases, Src and spleen tyrosine kinase (Syk), play crucial roles in cell responses to platelet-derived growth factor (PDGF) and may have their functional interactions. In this study, we focused on investigating the roles of Syk in the regulation of Src signaling in PDGF-mediated vascular cell responses. Migration, proliferation, and activity of kinases were determined in rat aortic smooth muscle cells (RASMCs). PDGF-BB (10 ng/mL) induced the migration and proliferation of RASMCs, which were significantly inhibited by PP2 (10 µM) and piceatannol (30 µM), inhibitors of Src and Syk, respectively. The phosphorylation of Syk induced by PDGFBB was abolished by PP2. PDGF-BB increased the co-association of the PDGFβ-receptor and the kinases, Src or Syk, and its maximal binding to Src was achieved in a shorter time than that to Syk. PDGF-BB stimulated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) 1/2, which was inhibited by PP2 and piceatannol. PDGF-BB-induced proliferation and migration were inhibited by SB203580 (30 µM) and PD98059 (30 µM), inhibitors of p38 MAPK and ERK1/2, respectively. These results imply that Syk is regulated by Src kinase, which participates in migration and proliferation in response to PDGF-BB in RASMCs.
Park, Nam Il,Xu, Hui,Li, Xiaohua,Jang, In Hyuk,Park, Suhyoung,Ahn, Gil Hwan,Lim, Yong Pyo,Kim, Sun Ju,Park, Sang Un American Chemical Society 2011 Journal of agricultural and food chemistry Vol.59 No.11
<P>Radish [<I>Raphanus sativus</I> (Rs)] is an important dietary vegetable in Asian countries, especially China, Japan, and Korea. To elucidate the molecular mechanisms of anthocyanin accumulation in radish, the gene expression of enzymes directly involved in anthocyanin biosynthesis was analyzed. These genes include phenylalanine ammonia lyase (<I>PAL</I>), cinnamate 4-hydroxylase (<I>C4H</I>), 4-coumarate–CoA ligase (<I>4CL</I>), chalcone synthase (<I>CHS</I>), chalcone isomerase (<I>CHI</I>), flavanone 3-hydroxylase (<I>F3H</I>), dihydroflavonol reductase (<I>DFR</I>), and anthocyanidin synthase (<I>ANS</I>). <I>RsDFR</I> and <I>RsANS</I> were found to accumulate in the flesh or skin of two radish cultivars (Man Tang Hong and Hong Feng No.1). Radish skin contained higher <I>CHS</I>, <I>CHI</I>, and <I>F3H</I> transcript levels than radish flesh in all three cultivars. In the red radish, 16 anthocyanins were separated and identified by high-performance liquid chromatography (HPLC) and elctrospray ionization–tandem mass spectrometry (ESI–MS/MS). Some of them were acylated with coumaroyl, malonoyl, feruoyl, and caffeoyl moieties. Furthermore (−)-epicatechin and ferulic acid were also identified in the three cultivars.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2011/jafcau.2011.59.issue-11/jf200824c/production/images/medium/jf-2011-00824c_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf200824c'>ACS Electronic Supporting Info</A></P>
Park, Jin Sun,Jung, Eul Sik,Choi, Woosuk,Park, Soo Yong,Rim, Min Young,Yu, Inku,Park, Hyeonsu,Lee, Sang Min,Park, Jeong-Woong,Jeong, Sung Hwan,Lee, Sang Pyo,Park, Sanghui The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.1
Methotrexate (MTX) has been established as a standard disease-modifying anti-rheumatic drug. If adequate disease control is achieved for a reasonable period of time, tapering the MTX dosage is recommended because the chronic use of MTX can result in opportunistic infection. We present here a case of a woman with rheumatoid arthritis taking MTX, and the woman developed actively caseating endobronchial Mycobacterium intracellulare disease with pulmonary infiltrations. After discontinuing the MTX, the patient was able to tolerate 18 months of antimycobacterial treatment without flare ups of rheumatoid arthritis, and she completely recovered from nontuberculous mycobacterial respiratory disease.
Park, Sanghui,Kang, So Young,Kwon, Ghee Young,Kwon, Ji Eun,Kim, Sang Kyum,Kim, Ji Yeon,Kim, Chul Hwan,Kim, Hyun-Jung,Moon, Kyung Chul,Pyo, Ju Yeon,Park, Won Young,Park, Eun Su,Sung, Ji-Youn,Sung, Sun College of American Pathologists; 1999 2017 ARCHIVES OF PATHOLOGY AND LABORATORY MEDICINE Vol.141 No.5