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박재원,홍지영,염준섭,조성래,오대규 대한감염학회 2009 감염과 화학요법 Vol.41 No.1
Background : Vivax malaria had spread rapidly in areas adjacent to the Demilitarized Zone to reach more than 4,000 cases in 2000 in the Republic of Korea (ROK). After year 2000, annual cases decreased rapidly to reach less than 1,000 cases in 2004. However, the number increased again since 2005. Epidemiological characteristics of vivax malaria in the ROK are different before and after 2000. This article was aimed to evaluate the current status of malaria elimination project in the ROK for providing suggestions for its improvement. Materials and Methods : We analyzed the total reported malaria cases during 2005 to 2007 and reviewed the record on the malaria eradication project performed by the authorizations including the Korea Center for Disease Control and Prevention. Results : During 2005 to 2007, 45% of all the vivax malaria occurred in patients living in the non-prevalent areas; the interval between first symptom onset and diagnosis was longer in the non-prevalent areas compared to that in the prevalent areas. Education and publicity on malaria has not been properly performed in the non-prevalent areas. The military didn't take part in the control of the malaria infected discharged soldiers, most of whom might have been infected with malaria during their military service. Conclusion : For the efficient control of malaria and thus improving the effectiveness of the elimination project education and publicity on malaria in the non-prevalent areas should be strengthened and cooperation between private and military sector regarding the ex-soldiers infected with malaria is essential, In addition, there should be bilateral communication among malaria-related teams within the Korea Centers for Disease Control and Prevention and also among all the malaria-related sectors. Furthermore a common database on malaria patients and vector mosquitoes should be formed to grant access to all the malaria-related sectors, Improvement on report and surveillance system is also necessary.
임사비나,임형택,박히준,장지련,최일환,이석찬,김대수,신희섭 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Objective : Acupuncture has been used for treatment of numerous disorders, especially for pain control in Oriental Medicine. However, the mechanism of pain control by acupuncture was not clear until now. This study was performed to prove analgesic mechanism of acupuncture treatment at acupoint ST_(36) by observing the changes of abdominal pain and c-Fos expression in the thalamus. Methods : Abdominal pain was induced by acetic acid, and the changes of writhing reflex after acupuncture treatment an ST_(36) and non-acupoints were measured. c-Fos immunohistochemistry was also performed to study the changes of the neuronal activity in the thalamus. Results : The writhing reflex decrease significantly after acupuncturing at ST_(36) compared with control group(p<0.05). The changes of the writhing reflex by non-acupoint acupuncture treatment also showed significant decrease compared with control group(p<0.05). c-Fos expression in the thalamus, especially periventricular part was significantly decreased after acupuncturing at ST_(36) compared with control groups(p<0.05). Conclusion : This study shows that the acupuncture has the analgesic effect in the abdominal pain induced by acetic acid and the thalamus might be a important area for this mechanism.
Porcine PD-L1: cloning, characterization, and implications during xenotransplantation
Jeon, Dae-Hyun,Oh, Keunhee,Oh, Byoung C.,Nam, Dong H.,Kim, Chi H.,Park, Hyung-Bae,Cho, Jaejin,Lee, Jeong R.,Lee, Dong-Sup,Lee, Gene Blackwell Publishing Ltd 2007 Xenotransplantation Vol.14 No.3
<P>Abstract: Background: </P><P>Effective intervention achieved by manipulating cell-mediated xenogeneic immune responses would critically increase the clinical feasibility of xenotransplantation as immediate hyperacute rejections become controllable through genetic modulations of donor organs. Endogenous negative regulatory signals like the programmed death 1 (PD-1)-programmed death ligand 1 (PD-L1) system are candidate targets for the control of cell-mediated xenogeneic immune response.</P><P>Methods: </P><P>A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology based on the human PD-L1 sequence. The functional effects of cloned porcine PD-L1 were tested on human CD4<SUP>+</SUP> T cell activation using porcine PD-L1-transfected bystander cells. Cellular proliferation was monitored by [<SUP>3</SUP>H] thymidine incorporation, and human T cell apoptosis was measured by flow cytometry.</P><P>Results: </P><P>Porcine PD-L1 (GenBank accession number AY837780) was found to have 73.8% sequence homology with human PD-L1 and to contain two immunoglobulin domains in its extracellular region. Moreover, porcine PD-L1 expressed on Chinese hamster ovary (CHO) cells inhibited human CD4<SUP>+</SUP> T cell proliferation stimulated with anti-CD3 only or anti-CD3 plus anti-CD28. Percentages of apoptotic activated human T cells increased by over 30% in the presence of porcine PD-L1/CHO cells, and the addition of recombinant human PD-1-Fc fusion proteins during human T cell activation reversed the inhibitory effects of porcine PD-L1.</P><P>Conclusions: </P><P>Cloned porcine PD-L1 showed high sequence homology with human PD-L1 and a similar molecular structure. Moreover, porcine PD-L1 inhibited human CD4<SUP>+</SUP> T cell activation in human PD-1-dependent manner, and this involved activated T cell apoptosis. The authors suggest that PD-1-PD-L1 might play an important endogenous immune regulatory role during xenogeneic transplantation, and that the effective application of this system would improve transplanted xenogeneic organ survival.</P>
A New Amorphous Semiconducting Polythiophene for High-Performance Organic Thin-Film Transistors
Kong, Hoyoul,Lee, Dong Hoon,Seo, Jung-In,Oh, Ji-Young,Chung, Dae Sung,Park, Jong-Won,Kwon, Soon-Ki,Lee, Yoon Sup,Park, Chan Eon,Shim, Hong-Ku American Chemical Society 2010 ACS APPLIED MATERIALS & INTERFACES Vol.2 No.4
<P>A new amorphous semiconducting polymer containing dodecylthiophene rings and a rigid thieno[3,2-<I>b</I>]thiophene ring, poly(2,5-bis(3′-dodecyl-2,2′-bithiophen-5-yl)thieno[3,2-<I>b</I>]thiophene) (<B>NAP</B>), was synthesized via a microwave-assisted Stille coupling reaction. The presence of the flexible unsubstituted thiophene ring units next to the rigid fused thiophene ring caused <B>NAP</B> to have an amorphous structure. This structure was confirmed by XRD, AFM, and computational calculations. In particular, the out-of-plane XRD patterns of <B>NAP</B> thin films exhibited no reflection peaks before or after the annealing process, indicating that the films had amorphous microstructures. In addition, AFM images of the <B>NAP</B> thin films showed amorphous surface morphologies with very small root-mean-square (rms) surface roughnesses of 0.3−0.5 nm, independent of surface treatment or heat treatment. Computational calculations performed to investigate the preferred conformation of the polymer confirmed the amorphous characteristics of the <B>NAP</B> structure. On the basis of these findings, we propose how an amorphous <B>NAP</B> semiconductor can maintain high carrier mobility. A <B>NAP</B>-based TFT device exhibited a very high carrier mobility of 0.02 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> with an on/off ratio of 1 × 10<SUP>5</SUP> and a very small threshold voltage of −2.0 V. This carrier mobility is the highest yet reported for TFTs based on amorphous semiconductors. Thus, the present findings suggest that an amorphous semiconductor layer comprised of <B>NAP</B> would be suitable for use in high-performance organic TFTs fabricated via simple processes in which neither surface treatment nor heat treatment is necessary.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2010/aamick.2010.2.issue-4/am9008852/production/images/medium/am-2009-008852_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am9008852'>ACS Electronic Supporting Info</A></P>
Park, Jin Sup,Cha, Kwang Soo,Lee, Dae Sung,Shin, Donghun,Lee, Hye Won,Oh, Jun-Hyok,Kim, Jeong Su,Choi, Jung Hyun,Park, Yong Hyun,Lee, Han Cheol,Kim, June Hong,Chun, Kook-Jin,Hong, Taek Jong,Jeong, Myu BMJ Publishing Group Ltd 2015 Heart Vol.101 No.15
<P><B>Objective</B></P><P>The value of multivessel revascularisation in cardiogenic shock and multivessel disease (MVD) is still not clear. We compared outcomes following culprit vessel or multivessel revascularisation in patients with ST-elevation myocardial infarction (STEMI), cardiogenic shock and MVD.</P><P><B>Methods</B></P><P>From 16 620 patients with STEMI who underwent primary percutaneous coronary intervention (PCI) in a nationwide, prospective, multicentre registry between January 2006 and December 2012, 510 eligible patients were selected and divided into culprit vessel revascularisation (n=386, 75.7%) and multivessel revascularisation (n=124, 24.3%) groups. The primary outcomes were inhospital mortality and all-cause death during a median 194-day follow-up. A weighted Cox regression model was constructed to determine the HRs and 95% CIs for outcomes in the two groups.</P><P><B>Results</B></P><P>Compared with culprit vessel revascularisation, multivessel revascularisation had a significantly lower adjusted risk of inhospital mortality (9.3% vs 2.4%, HR 0.263, 95% CI 0.149 to 0.462, p<0.001) and all-cause death (13.1% vs 4.8%, HR 0.400, 95% CI 0.264 to 0.606, p<0.001), mainly because of fewer cardiac deaths (9.7% vs 4.8%, HR 0.510, 95% CI 0.329 to 0.790, p=0.002). In addition, multivessel revascularisation significantly decreased the adjusted risk of the composite endpoint of all-cause death, recurrent myocardial infarction and any revascularisation (20.3% vs 18.1%, HR 0.728, 95% CI 0.55 to 0.965, p=0.026).</P><P><B>Conclusions</B></P><P>This study showed that, compared with culprit vessel revascularisation, multivessel revascularisation at the time of primary PCI was associated with better outcomes in patients with STEMI with cardiogenic shock. Our results support the current guidelines regarding revascularisation in these patients.</P>