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朴永錫,梁海承,姜秋遠 조선대학교 생산기술연구소 1981 生産技術硏究 Vol.1981 No.-
The purpose of this paper is to identify the geology of limestone deposit in Hwasun area so that the most reasonable development method can be planned. The detailed geological study were carried out several times during the period of February 1979 to August 1980. The samples taken under such geological studies of Hwasun area were observed by microscope the composition, the grade of minerals, and the states of re-crystallization. The limestone deposit of the studied area is principally distributed under the Sulokri and Osanri formations. The limestone deposit under the Sulokri formation, however, has no economic value due to the presence of slate and the uncontinuity of strata. The limestone deposited under Osanri formation seems to be reasonably economical in A and B areas. The results of chemical analysis and the estimated reserves by 168 samples of this area are as follows : 1. Chemical compositions of A area; CaO 46.2%, MgO 3.1% 2. Chemical compositions of B area; CaO 45.8%, MgO 3.3% 3. The estimated minable reserves of limestone in B area is approximately 10 million tons of which can be valuable for raw material of cement.
Design and synthesis ofα,β-unsaturated carbonyl compounds as potential ACE inhibitors
Park Choo, Hea-Young,Peak, Kyung-Hee,Park, Jongsei,Kim, Dong Hyun,Chung, Hak Soon 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
The α, β-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly.
The 3-D-QSAR Study of Antitumor Arylsulfonylimidazolidinone Derivatives by CoMFA and CoMSIA
Park Choo, Hea-Young,Choi, Suyoung,Jung, Sang-Hun,Koh, Hun Yeong,Pae, Ae Nim 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies for a series of arylsulfonylimidazolidinone derivatives having antitumor activity were conducted using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices anaysis (CoMSIA). The in vitro cytotoxicity against human lung carcinoma (A549) exhibited a strong correlation with steric and electrostatic factors of the molecules. Four different types of models have been built using CoMFA and CoMSIA method with AMI charge or Gasteiger-Huckel charge. By comparison of the statistical results of these models, model I obtained by CoMFA study with AMI showed the best predictability of the antitumor activities based on the cross- validated value (0.642), conventional r² (0.981), standard error of estimate (0.106) and PRESS value (0.170).
Park Choo, Hea-Young,Choi, Suyoung,Ryu, Chung-Kyu,Kim, Hwa-Jung,Lee, In Youn,Pae, Ae Nim,Koh, Hun Yeong 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vaso-relaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q² (0.741) and r² (0.960) values, gave reliability to the prediction of inhibitory activity of this series.
Park Choo, Hea-Young,Lim, Jae-Su,Kam, Yurim,Kim, Su Yeon,Lee, Jeewoo 梨花女子大學校 藥學硏究所 2001 藥學硏究論文集 Vol.- No.10
A series of 28 diarylsulfonylureas with antitumor activity was subjected to a three-dimensional quantitative relationship was subjected to a three-dimensional quantitative relationship(SD-QSAR) study. Three different QSAR methods, comparative molecular filed analysis(CoMFA), holograx(HQSAR) and comparative molecular similarity indices analysis(CoMSIA), were compared in terms of their pote predictability. All three QSAR-based models had good predictability and yielded q^2 values 0.74, 0.63 and 0.72 repective CoMFA model provided the highest q^2 and r^2 values, which implied the significance of correlation of steric and electrosta with biological activities. The number of components was 3_4 for all three QSAR methods. The quality of HASAR or was slightly lower than that of CoNFA in terms of q^2 and r^2 values. HQSAR does not require the generation of a three-din structure of molecules and CoMSIA does not require molecular superposition, therefore they are faster than CoMFA processing.
Epoxidation of β,γ-Unsaturated Carboxylic Acids by Dimethyldioxirane
Park Choo, Hea-Young 梨花女子大學校 藥學硏究所 1994 藥學硏究論文集 Vol.- No.4
Peroxy acids, one of the most commonly used electrophilic epoxidizing agents, are not effetive in the epozidation of clefins containing carboxyl groups because of electron with drawing property of the carboxyl group. Moreover the acid generated from the peroxyacid is difficult to separate from the desired product, epoxy acid. Nucleophilic epoxidizing agents, hydrogen perozide together with various catalysts (base, tungsten, etc), are effective only to α ,β-unsaturated acids. Recently dimethyldioxirane has been employed for epoxidation of α,β-unsaturated ketones, acids and esters. Not only electron rich alkenes such as enol ethers and lactones but also electron poor alkenes such as vinyltetrazoles, flavons are also epoxidized by dimethylodioxirane in high yeild. But not many unsaturated carboxylic acids have been epoxidized by dimethyldioxirane. Here we report this powerful agent, which can be generated in situ from potassium peroxomonosulfate (oxone) and acetone, is effective in the epoxidation of β, γ-unsaturated acids.
The Metabolism of Xylazine in Rats
Park Choo, Hea-Young,Choi, Sun-Ok 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2
The biotransformation of xylazine, a widly used animal tranquilizer, was investigated in rats. After administration of xylazine, the existence of 2.6-dimethylphenylsothiocyanate. 2.6-dimenthyl-4-hydroxy-aniline and p-hydroxy-xylazine in urine was confirmed by the comparison with chemically prepared stnadards in GC/MS. The main metabolite. p-hydroxy xylazine was excreted as conjugated form.
Choo, Hea-Young,Park, Jeongeun,Park, Myung-Ja Korean Society of ToxicologyKorea Environmental Mu 1991 Toxicological Research Vol.7 No.1
Barbiturates are commonly abused tranquilizer and a rapid method to determine these drugs in biological samples is needed. In this study, was screened barbiturates in urine specimens by the fluorescence polarization immunoassay method(FPIA) and the positive samples were confirmed and identified by the more definitive GC/MS method. Fifteen positive smples which have barbiturate values higher than 0.5 ng/ml were analyzed by the GC/MS method. Eight samples were identified as phenobarbital and five samples were identified as crotilbarbitone.
3D QSAR Studies on New Piperazine Derivatives with Antihistamine and Antibradykinin Effects
Park Choo, Hea-Young,Chung, Bum-Jun 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
Three dimensional QSAR studies for antihistamine and antibradykinin effects of new piperazine derivatives were conducted using the comparative molecular field analysis. Electrostatic and steric factors, but not hydrophobic factor, of the synthesized compounds were correlated with the antagonistic effect.
Solid-Phase Combinatorial Synthesis and Cytotoxicity of 3-Aryl-2,4-quinazolindiones
Park Choo, Hea-Young,Kim, Mihyun,Lee, Sang Kook,Kim, Sang Woong,Chung, In Kwon 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prtpatrd by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.