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Neural Network Training Using a GMDH Type Algorithm
Pandya, Abhijit S.,Gilbar, Thomas,Kim, Kwang-Baek Korean Institute of Intelligent Systems 2005 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.5 No.1
We have developed a Group Method of Data Handling (GMDH) type algorithm for designing multi-layered neural networks. The algorithm is general enough that it will accept any number of inputs and any sized training set. Each neuron of the resulting network is a function of two of the inputs to the layer. The equation for each of the neurons is a quadratic polynomial. Several forms of the equation are tested for each neuron to make sure that only the best equation of two inputs is kept. All possible combinations of two inputs to each layer are also tested. By carefully testing each resulting neuron, we have developed an algorithm to keep only the best neurons at each level. The algorithm's goal is to create as accurate a network as possible while minimizing the size of the network. Software was developed to train and simulate networks using our algorithm. Several applications were modeled using our software, and the result was that our algorithm succeeded in developing small, accurate, multi-layer networks.
Low Power Design of the Neuroprocessor
Pandya, A.S.,Agarwal, Ankur,Chae, G.Y. Korean Institute of Intelligent Systems 2004 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.4 No.1
This paper presents the performance analysis for CPL based design of a Low power digital neuroprocessor. We have verified the functionality of the components at the high level using Verilog and carried out the simulations in Silos. The components of the proposed digital neuroprocessor have also been verified at the layout level in LASI. The layouts have then been simulated and analyzed in Winspice for their timing characteristics. The result shows that the proposed digital neuroprocessor consistently consumes less power than other designs of the same function. It can also be seen that the proposed functions have lesser propagation delay and thus higher speed compared to the other designs.
New macrobicyclic chelator for the development of ultrastable 64Cu-radiolabeled bioconjugate.
Pandya, Darpan N,Dale, Ajit V,Kim, Jung Young,Lee, Hochun,Ha, Yeong Su,An, Gwang Il,Yoo, Jeongsoo American Chemical Society 2012 Bioconjugate chemistry Vol.23 No.3
<P>Ethylene cross-bridged cyclam with two acetate pendant arms, ECB-TE2A, is known to form the most kinetically stable (64)Cu complexes. However, its usefulness as a bifunctional chelator is limited because of its harsh radiolabeling conditions. Herein, we report new cross-bridged cyclam chelator for the development of ultrastable (64)Cu-radiolabeled bioconjugates. Propylene cross-bridged TE2A (PCB-TE2A) was successfully synthesized in an efficient way. The Cu(II) complex of PCB-TE2A exhibited much higher kinetic stability than ECB-TE2A in acid decomplexation studies, and also showed high resistance to reduction-mediated demetalation. Furthermore, the quantitative radiolabeling of PCB-TE2A with (64)Cu was achieved under milder conditions compared to ECB-TE2A. Biodistribution studies strongly indicate that the (64)Cu complexes of PCB-TE2A cleared out rapidly from the body with minimum decomplexation.</P>
Revival of TE2A; a better chelate for Cu(II) ions than TETA?
Pandya, Darpan N.,Kim, Jung Young,Park, Jeong Chan,Lee, Hochun,Phapale, Prasad B.,Kwak, Wonjung,Choi, Tae Hyun,Cheon, Gi Jeong,Yoon, Young-Ran,Yoo, Jeongsoo Royal Society of Chemistry 2010 Chemical communications Vol.46 No.20
<P>A highly effective synthetic route for TE2A was developed and the <SUP>64</SUP>Cu-labeled TE2A complexes showed higher kinetic inertness and faster clearance than most commonly used TETA analogs.</P> <P>Graphic Abstract</P><P>A facile synthetic route for TE2A was developed and TE2A was found to make a more kinetically stable Cu(II) complex than TETA. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b925703a'> </P>
Transaminases for Green Chemistry: Recent Progress and Future Prospects
Pandya Shreya,Gupte Akshaya 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.4
Transaminase represents the most important biocatalysts used for the synthesis of chiral amines due to their stereoselectivity. They allow asymmetric synthesis with high yields and enantioselectivity from their corresponding ketones. Due to their environmentally friendly access for the preparation of chiral amines, they have attracted growing attention in recent times. Thus, the production of chiral compounds by transaminase catalysed reactions is considered as an important application in synthetic organic chemistry. Therefore, transaminase is considered to be an important enzyme in the pharmaceutical and chemical industries. ω-Transaminase holds great potential because of its wide substrate specificity thus making it a suitable enzyme to be used at an industrial scale. This review highlights the reaction mechanism, classification, substrate specificity, and biochemical properties. The review also showcases the application of ω-transaminase in organic chemistry with a focus on the production of active pharmaceutical ingredients (APIs).
A New Synthesis of TE2A-a Potential Bifunctional Chelator for $^{64}Cu$
Pandya, Darpan N.,Kim, Jung Young,Kwak, Won-Jung,Park, Jeong-Chan,Gawande, Manoj B.,An, Gwang-Il,Ryu, Eun-Kyoung,Yoo, Jeong-Soo The Korea Society of Nuclear Medicine 2010 핵의학 분자영상 Vol.44 No.3
Purpose The development of a new bifunctional chelator, which holds radiometals strongly in living systems, is a prerequisite for the successful application of diseasespecific biomolecules to medical diagnosis and therapy. Recently, TE2A was reported to make kinetically more stable Cu(II) complexes than TETA. Herein, we report a new synthetic route to TE2A and explore its potential as a bifunctional chelator. Methods TE2A was synthesized using the regioselective alkylation of benzyl bromoacetate and successive deprotection of the methylene bridge and benzyl group. Salt-free TE2A was radiolabeled with $^{64}Cu$ and microPET imaging was performed to follow the clearance pattern of the $^{64}Cu$-TE2A complex. TE2A was conjugated with cyclic RGD peptide and the TE2A-c(RGDyK) conjugate was radiolabeled with $^{64}Cu$. Results TE2A was prepared in salt-free form from cyclam in an overall yield of 74%. The microPET images showed that $^{64}Cu$-TE2A is excreted rapidly from the body by the kidney and liver. TE2A was successfully conjugated with c(RGDyK) peptide through one carboxylate group and the TE2A-c(RGDyK) conjugate was radiolabeled with $^{64}Cu$ in 94% yield within 30 min. Conclusion TE2A can be used by itself as a bifunctional chelator without any further structural modification.
Pandya, Darpan N.,Bhatt, Nikunj,An, Gwang Il,Ha, Yeong Su,Soni, Nisarg,Lee, Hochun,Lee, Yong Jin,Kim, Jung Young,Lee, Woonghee,Ahn, Heesu,Yoo, Jeongsoo American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.17
<P>The first macrocyclic bifunctional chelator incorporating propylene cross-bridge was efficiently synthesized from cyclam in seven steps. After the introduction of an extra functional group for facile conjugation onto the propylene cross-bridge, the two carboxylic acid pendants could contribute to strong coordination of Cu(II) ions, leading to a robust Cu complex. The cyclic RGD peptide conjugate of PCB-TE2A-NCS was prepared and successfully radiolabeled with <SUP>64</SUP>Cu ion. The radiolabeled peptide conjugate was evaluated in vivo through a biodistribution study and animal PET imaging to demonstrate high tumor uptake with low background.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-17/jm500348z/production/images/medium/jm-2014-00348z_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm500348z'>ACS Electronic Supporting Info</A></P>
Realization of Bluetooth Piconet for Real Time Monitoring of Multiple Parameters
Utpal T. Pandya,Uday B. Desai,Shabbir N. Merchant 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.2
Purpose There are many applications where simultaneous wireless transmission of many parameters is required to be sent to base station or to the receiver. For example, in case of mass causality events, monitoring of multiple patients by medical technicians, physicians or nurses is required where there will be more than one wireless transmitter and one wireless receiver Methods In this paper, to demonstrate and address the issue of such applications, an adhoc network is realized by formation of a piconet in the Bluetooth environment for the real time monitoring. Each Bluetooth device captures continuous, real time simulated signals and relays the data to Bluetooth enabled laptop where received signals are further processed. Results It is revealed that the proposed system can be used to implement Bluetooth piconet and can be an effective means for the monitoring of any parameters of multiple systems. As a proof of concept, implementation of Bluetooth piconet to capture ECG of two subjects simultaneously in real time mode is also shown. Conclusions The data analysis suggests that an algorithm is required to address wireless transmission issues like latency along-with noise filtering. This algorithm should be easily implemented in existing Mobile/PDA/Laptop, etc. to meet the requirement of low cost and adaptability.