Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic

Pan Jin,Fuqiang Yin,Li Huang,Li Zheng,Jinmin Zhao,XINGDONG ZHANG 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Neuro-osteological interactions have an important role in the regulation of bone metabolism and regeneration. Neuropeptides combined with porous biphasic calcium phosphates (BCP) using protein adsorption may contribute to the acceleration of bone formation. In the present study, we investigated the effect of BCP combined with nerve growth factor (NGF) on the growth of osteoblasts in vitro and the combinational therapeutic effect on the repair of calvarial defects in vivo. NGF was separated and purified from Chinese cobra venom using a simplified three-step chromatography method. BCP combined with NGF exerted a potent effect on osteoblast differentiation, as evidenced by enhanced cell proliferation, increased ALP activity and the upregulated expression of osteogenesis-related genes and proteins. Further, combinational therapy with BCP and NGF improved calvarial regeneration, which was superior to treatment with therapy alone, as observed using imageological and morphological examination and histological and immunohistochemical staining. The results confirmed the effect of neuro-osteological interactions through combinatorial treatment with NGF and BCP to promote osteogenesis and bone formation, which may provide an effective and economical strategy for clinical application.

Stimulating Effect of a Novel Synthesized Sulfonamido-Based Gallate ZXHA-TC on Primary Osteoblasts

PAN JIN,Li Zheng,Liang Liao,Xiao Lin,Qinggong Guo,Cui-Wu Lin,Huayu Wu,Jinmin Zhao 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.3

Purpose: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention of osteoporosis through the maintenance of reactive oxygenspecies (ROS) at a favorable level. Materials and Methods: In this study, a novel antioxidant, namely 3,4,5-Trihydroxy-N-[4-(5-hydroxy-6-methoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-benzamide (ZXHA-TC) was synthesized from gallic acid and sulfadimoxine. Its effect on osteoblast metabolism was investigated via the detection of cell proliferation, cell viability, production of ROS, and expression of osteogenic-specific genes including runt-related transcription factor 2 (RUNX2), bone sialoprotein (BSP), osteocalcin (OCN), alpha-1 type I collagen (COL1A1), and osteogenic-related proteins after treatment for 2, 4, and 6 days respectively. Results: The results showed that ZXHA-TC has a stimulating effect on the proliferation and osteogenic differentiation of primary osteoblasts by promoting cell proliferation, cell viability, and the expression of genes BSP and OCN. Productions of bone matrix and mineralization were also increased by ZXHA-TC treatment as a result of up-regulationof COL1A1 and alkaline phosphatase (ALP) at the early stage and down-regulationof both genes subsequently. A range of 6.25×10-3 μg/mL to 6.25×10-1 μg/mL is the recommended dose for ZXHA-TC, within which 6.25×10-2 μg/mL showed the best performance. Conclusion: This study may hold promise for the development of a novel agent for the treatment of osteoporosis.

An Analyze of the Development Experiences and Status quo of Electronic Commerce in China

Pan Jin’e 국제e-비즈니스학회 2007 e-비즈니스 연구 Vol.1 No.1

Electronic Commerce appears late in China while progresses rapidly. This paper firstly introduces the developmental stages of E-commerce in China, and then draws out a whole picture of the status in quo. Basing on the analyses of the disadvantages and advantages, this paper predicts future of E-commerce in China as follow: A new period for deep developing E-commerce in China is coming, which will be very potential and promising.

제32회 춘천인형극제의 교육적 특성 고찰

오판진 ( Oh¸ Pan Jin ) 서울교육대학교 초등교육연구원 2021 한국초등교육 Vol.32 No.3

어린이들이 인형을 조작하면서 공부하는 교육 프로그램 개발에 관한 연구는 활발하다. 그러나 어린이들이 인형놀이를 직접 하는 것과 다른 인형극 공연을 관람하는 것의 교육적 효과에 관한 연구는 상대적으로 미흡하다. 이 연구의 목적은 온라인으로 진행된 제32회 춘천인형극제 인형극 작품의 교육적인 특성을 고찰하는 데 있다. 32개의 참가작에 어떤 교육적 특성이 나타나는지 연행 이론으로 구명하기 위해 언어 텍스트, 연희 텍스트, 문화적 컨텍스트 층위에서 분석하였다. 그 결과 언어 텍스트 층위의 특성으로는 ‘언어 이해력 증진’과 ‘풍부한 서사 체험’, ‘건전한 정체성 형성’이 있고, 연희 텍스트 층위의 특성에는 ‘시각적 리터러시’, ‘청각적 리터러시’, ‘실감 나는 언어 표현’이 있으며, 문화적 컨텍스트 층위의 특성으로는 ‘전통문화의 이해’, ‘새로운 공연문화 향유’, ‘공연 감상 예절’이 있다는 것을 밝혔다. 그래서 어린이들이 음성언어와 함께 신체언어와 이미지언어 등 비일상적인 풍부한 언어표현을 만날 수 있고, 국내와 국외의 다양한 서사에서 느낄 수 있는 즐거움을 체험할 수 있으며, 인형이라는 효과적인 형상을 통해 인간과 세상을 바라보는 가치관을 바르게 형성할 수 있다. 그리고 평소에 보기 어려운 인형이나 무대장치, 조명 등이 사용되는 수준 높은 인형극 무대와 배우들의 실감나고 세련된 대사와 음향, 음악 등이 조화롭게 어울리는 통합된 공연예술을 경험할 수 있다. 또한 우리의 전통문화를 배경으로 한 인형극과 이전에 볼 수 없었던 창의적인 인형극을 관람함으로써 세계 속에 살아갈 예절 바른 한국인이라는 정체성을 형성할 수 있다. 제32회 춘천인형극제 인형극 작품 속에 이런 교육적 특성이 나타나기 때문에 학교와 가정에서는 어린이들이 공연을 감상할 때 이를 고려하여 관람하길 바란다. 아울러 춘천인형극제 인형극 작품에 또 다른 측면의 특성이 있는지를 분석하는 후속 연구가 이어져서 춘천인형극제 인형극이 관객들과 뜻깊은 만남을 이어갈 수 있기를 기대한다. The purpose of this study is to examine the educational attributes of the 32nd Chuncheon Puppet Festival works which was conducted online. The analysis was conducted on layers of language text, chronological text, and cultural context to determine what educational attributes appeared in 32 participating works as a theory of engagement. As a result, the attributes of the language text layer include “improvement of language comprehension”, “experience of rich narrative”, “formation of sound identity”, “audible literacy”, “real language expression” and “experience of traditional culture”, “new performance culture”. Therefore , children can meet unusual rich language expressions such as body language and image language along with voice language, experience the joy of various narratives at home and abroad, and form values that view humans and the world correctly through the effective shape of puppets . In addition, you can experience a high-quality puppet show stage where puppets, stage equipment, and lighting, which are difficult to see, and integrated performing arts that harmonize actors’ realistic and sophisticated lines, sound, and music. In addition, we can form a polite Korean identity to live in the world by watching puppet shows set in our traditional culture and creative puppet shows that have not been seen before. Since these educational attributes appear in the 32nd Chuncheon Puppet Festival works, schools and families should consider them when they appreciate the performance. In addition, follow-up studies to analyze whether there are other aspects of the Puppet Festival of Chuncheon will be followed, and it is expected that the Puppet Festival of Chuncheon will continue to meet with the audience.

Study on Daeryuk Baekje: Focusing on Literature Research

Panjin KIM,Myoung-Kil YOUN 한국한류학회 2023 한류연구 Vol.2 No.2

Study on Daeryuk Baekje: Focusing on Literature Research

Panjin KIM,Myoung-Kil YOUN Korea Koreanology Association 2023 Journal of Koreanology Reviews Vol.2 No.2

Purpose: The purpose of this study is to discuss on Daeryuk Baekje (the Continental Baekje), as new researches are beginning to emerge on the existing theory that Baekje exits only in the Korean Peninsula. Research design, data and methodology: We intend to systematically reveal this new theory by carefully examining the early founding process of Baekje, the process of determining its capital city and the ancient documents related to it. Objective analysis and research were conducted through literature research including not only domestic research data but, also research data from overseas. Results: Baekje existed on the Continent and on the Peninsula in the early days of Baekje establishment, before the Kingdom was established, so-called Hanseong Baekje. Conclusion: Biryu and Onjo settled down near Yoseo and Jinpyeong when they first moved to the south from Goguryeo. Biryu led hundred families to Michuhol and established Baekje. Onjo established Sipje at the Wirye Castle with ten of his servants. After Biryu's death the people of Baekje pledge allegiance to Onjo. The Sipje changed its country's name to Baekje. This illustrates that the country was operated with a capital in two regions, in the Continent and the Korean Peninsula. The country was ruled under two royal castles with 22 provincial governments (Dam-ro). Each area was ruled by the royal families and the competent prince among them succeeded to the next throne. It is a unique governing system and illustrates that Baekje existed in the Continent.

고령사회 노인연극의 지향점 고찰 : 당진시 ‘회춘유랑단’을 중심으로

오판진(Panjin Oh) 한국노년학회 2020 한국노년학 Vol.40 No.2

본 연구의 목적은 문화지원 측면의 노인복지에 속하는 노인연극 프로그램의 한 사례를 분석하여 노인연극의 지향점을 고찰하는 데 있다. 이를 위해 충남 당진시 할머니들로 구성된 ‘회춘유랑단’의 활동 사례를 조사하고, 그 공연 내용을 분석하였다. 연구 방법은 사례 연구와 연행 이론을 사용하였으며, 동료 검토법(peer examination)의 전략을 사용하여 연구의 타당도를 높였다. 연구 결과, 노인연극 프로그램을 통해 할머니들은 첫째, 어린이와 청소년들과의 소통을 지향했고, 둘째, 몸이 불편한 다른 노인들과 소통하기를 원했으며, 셋째, 청년이나 중년은 물론 모든 주민과 소통하길 바랐고, 넷째, 연극이라는 새로운 장르를 체험하여 자신의 정체성을 확인하고 성취감을 높이면서 노년을 즐겁고 유익하게 보냈다는 것을 알 수 있었다. 이런 연구 결과를 바탕으로 아래와 같은 제언을 하였다. 첫째, ‘회춘유랑단’을 밴치마킹한 노인연극 프로그램을 확대해야 한다. 둘째, 노인연극에 관한 다양한 사례를 연구하고, 이런 노인연극을 지원하는 정책 연구도 필요하며, 노인연극 전문가를 양성하는 교육 과정도 개발해야 한다. 셋째, 노인연극 프로그램이 지역적인 한계를 벗어나 국내와 국외의 단체들과 교류하는 방안도 모색해야 한다. 넷째, 연극치료 분야에서도 새로운 길을 모색할 여지가 있고, 소시오드라마나 사이코드라마 프로그램 개발이 대안이 될 수 있다. The purpose of this study is to examine the direction of the elderly theatre by analyzing an example of the elderly theatre program which is attempted in a way of the welfare of senior citizens in terms of cultural support. To this end, the ‘Hoechun Circus’ composed of elderly women in Dangjin, South Chungcheong Province, was investigated and analyzed. Research methods uses a case study, performance theory, and peer review strategies to increase the validity of the study. The results of the study are as follows: Firstly, the elderly women intended to communicate with children and adolescents through performance; Secondly, they wanted to communicate with other physically uncomfortable elderly people; Thirdly, they also attempted to communicate with young or middle-aged as well as all residents; Fourthly, they experienced a new genre of theatre to identify themselves in a different ways and enhance their sense of accomplishment and spent their old age pleasantly and informally. Based on these findings, the following suggestions were made. First, we should expand the theatre programs of senior citizens which benchmark the ‘Hoechun Circus’. Second, various cases of elderly theater should be studied and policy research to support such elderly theatre is necessary. Besides, educational courses to train elderly theatre experts should also be developed. Third, it should also seek ways for the program to move beyond regional limits and interact with organizations at home and abroad. Fourth, there is room to explore new ways in the field of theater therapy, and the development of sociodrama or psychodrama programs can be an alternative.

Orbital Dzyaloshinskii-Moriya exchange interaction

Kim, Panjin,Han, Jung Hoon American Physical Society 2013 Physical review. B, Condensed matter and materials Vol.87 No.20

Nature of orbital and spin Rashba coupling in the surface bands ofSrTiO3andKTaO3

Kim, Panjin,Kang, Kyeong Tae,Go, Gyungchoon,Han, Jung Hoon American Physical Society 2014 Physical review. B, Condensed matter and materials Vol.90 No.20

Featureless quantum insulator on the honeycomb lattice

Kim, Panjin,Lee, Hyunyong,Jiang, Shenghan,Ware, Brayden,Jian, Chao-Ming,Zaletel, Michael,Han, Jung Hoon,Ran, Ying American Physical Society 2016 Physical Review B Vol.94 No.6

<P>We show how to construct fully symmetric states without topological order on a honeycomb lattice for S = 1/2 spins using the language of projected entangled pair states. An explicit example is given for the virtual bond dimension D = 4. Four distinct classes differing by lattice quantum numbers are found by applying the systematic classification scheme introduced by two of the authors [ S. Jiang and Y. Ran, Phys. Rev. B 92, 104414 (2015)]. Lack of topological degeneracy or other conventional forms of symmetry breaking in the proposed wave functions are checked by numerical calculations of the entanglement entropy and various correlation functions. Exponential decay of all correlation functions measured are strongly indicative of the energy gap for the putative parent Hamiltonian of the state. Our work provides the first explicit realization of a featureless quantum state for spin-1/2 particles on a honeycomb lattice.</P>