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RISS 인기검색어
- 검색키워드
- 저자 : Palenchar, Daniel J. (검색결과 1 건)
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Gellatly, Kyle J.,Krim, Sarah,Palenchar, Daniel J.,Shepherd, Katie,Yoon, Kyong Sup,Rhodes, Christopher J.,Lee, Si Hyeock,Marshall Clark, J. Oxford University Press 2016 Journal of medical entomology Vol.53 No.3
<P>Pediculosis is a prevalent parasitic infestation of humans, which is increasing due, in part, to the selection of lice resistant to either the pyrethrins or pyrethroid insecticides by the knockdown resistance (<I>kdr</I>) mechanism. To determine the extent and magnitude of the <I>kdr</I>-type mutations responsible for this resistance, lice were collected from 138 collection sites in 48 U.S. states from 22 July 2013 to 11 May 2015 and analyzed by quantitative sequencing. Previously published data were used for comparisons of the changes in the frequency of the <I>kdr</I>-type mutations over time. Mean percent resistance allele frequency (mean % RAF) values across the three mutation loci were determined from each collection site. The overall mean % RAF (±SD) for all analyzed lice was 98.3 ± 10%. 132/138 sites (95.6%) had a mean % RAF of 100%, five sites (3.7%) had intermediate values, and only a single site had no mutations (0.0%). Forty-two states (88%) had a mean % RAF of 100%. The frequencies of <I>kdr</I>-type mutations did not differ regardless of the human population size that the lice were collected from, indicating a uniformly high level of resistant alleles. The loss of efficacy of the Nix formulation (Prestige Brand, Tarrytown, NY) from 1998 to 2013 was correlated to the increase in <I>kdr</I>-type mutations. These data provide a plausible reason for the decrease in the effectiveness of permethrin in the Nix formulation, which is the parallel increase of <I>kdr</I>-type mutations in lice over time.</P>
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