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Sunju Park,함대현,주명수,KyongminKim,Sunoh Kwon,최호영,이향숙 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3
Background: Experiencing difficulties and challenges though COVID-19 pandemic, there are voices that it needs to be discussed to seek direction of basic research and college education of Korean Medicine (KM) so that KM community can play a significant role in the future infectious disease outbreaks. Methods: This paper summarizes the edited highlights of an online video meeting by Google meet on May 19, 2020, organized by the Korean Medicine Convergence Research Information Center. Five researchers specialized in immunology, microbiology, virology, preventive medicine, and herbology, respectively, presented what KM community should prepare for the future acute infectious disease outbreaks by learning from the previous research on antiviral effect of herbs for coronavirus and the experiences of the present COVID-19 pandemic. Results: There are a lot of herbs or natural products with potential anti-coronavirus effects reported from in vitro experiments and despite criticism, many clinical trials on traditional herbal medicine for COVID-19 are being conducted. In addition to establishing research evidence, KM community should train and produce public health professionals among Korean Medicine Doctors (KMDs) and official participation in public healthcare system should be ensured in terms of regulation and policy. Newly developed KM treatments can be interpreted by the KM theories and also should be allowed by regulations for KMDs to utilize them. Conclusion: The present online discussion suggested directions of basic research for acute viral infections diseases utilizing KM and how to enforce relevant education and regulations in the post-COVID-19 era.
Park, Sunju,Park, Hae-Mo,Sun, Seung-Ho KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.2
Objective:This study is to evaluate both the single-dose intravenous injection toxicity and the approximate lethal dose of Water-soluble Danggui Pharmacopuncture (WDP) in Sprague-Dawley (SD) rats. Methods: Toxicity experiments were conducted at Good Laboratory Practice (GLP) laboratory in Biotoxtech Co., according to the regulations of GLP. WDP injection of dose 0.125, 0.25, and 0.5 mL/animal were experimental groups and normal saline injection group was control group. WDP and normal saline were injected once to 6- week old 5 male and 5 female SD rats at the tail veins at approximately 2 mL/min. During 14 days after the injection, general symptoms were observed and weight were measured. After the observation period, hematological and blood biochemical examination, macroscopic autopsy, topical resistance test at the injection area were performed. Results: RThe WDP 0.5 mL/animal injection group in 4 cases of male rats and all cases of female rats showed hematuria 30 minutes after the administration. However, after 1 hour, no more abnormal general symptoms were observed. The WDP did not affect weight, hematological and blood biochemical examination, macroscopic autopsy, and topical resistance test at the injection area. Conclusion: WDP single dose intravenous injection results showed that WDP have no toxic effects and a lethal dose of WDP should be over 0.5 mL/animal in male and female rats under the study condition. So WDP may be safe.
Park, Sunju,Sun, Seung-Ho KOREAN PHARMACOPUNCTURE INSTITUTE 2015 Journal of pharmacopuncture Vol.18 No.3
Objectives: The aim of the study is to investigate both the single-dose intramuscular injection toxicity and the approximate lethal dose of water-soluble Carthami-flos and Cervi cornu parvum pharmacopuncture (WCFC) in male and female Sprague-Dawley (SD) rats. Methods: The study was conducted at Biotoxtech Co. according to the Good Laboratory Practice (GLP) regulation and the toxicity test guidelines of the Ministry of Food and Drug Safety (MFDS) after approval of the Institutional Animal Care and Use Committee. Dosages for the control, high dose, middle dose and low dose groups were 0.5 mL/animal of saline and 0.5, 0.25 and 0.125 mL/animal of WCFC, respectively. WCFC was injected into the muscle of the left femoral region by using a disposable syringe (1 mL, 26 gauge). The general symptoms and mortality were observed 30 minutes, 1, 2, 4, and 6 hours after the first injection and then daily for 14 days after the injection. The body weights of the SD rats were measured on the day of the injection (before injection) and on the third, seventh, and fourteenth days after the injection. Serum biochemical and hematologic tests, necropsy examinations, and histopathologic examinations at the injection site were performed after the observation period. Results: No deaths, abnormal clinical symptoms, or significant weight changes were observed in either male or female SD rats in the control or the test (0.125, 0.25, and 0.5 mL/animal) groups during the observation period. No significant differences in hematology and serum biochemistry and no macroscopic abnormalities at necropsy were found. No abnormal reactions at injection sites were noted on the topical tolerance tests. Conclusion: The results of this single-dose toxicity study show that WCFC is safe, its lethal doses in male and female SD rats being estimated to be higher than 0.5 mL/animal.
Park, Sunju,Nahmkoong, Won,Cheon, ChunHoo,Park, Jeong-Su,Jang, Bo-Hyoung,Shin, Yongcheol,Kim, Kyung-Soo,Go, Hoyeon,Song, Yun-Kyung,Ko, Seong-Gyu Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P><I>Objective</I>. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. <I>Methods</I>. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (<I>n</I> = 57) group or the placebo group (<I>n</I> = 55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. <I>Results</I>. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (<I>P</I> = 0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (<I>P</I> < 0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. <I>Conclusion</I>. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.</P>
Park, Jihoon,Ham, Seunghon,Jang, Miyeon,Lee, Jinho,Kim, Sunju,Kim, Sungkyoon,Lee, Kiyoung,Park, Donguk,Kwon, Jungtaek,Kim, Hyunmi,Kim, Pilje,Choi, Kyunghee,Yoon, Chungsik American Chemical Society 2017 Environmental science & technology Vol.51 No.13
<P>We evaluated the spatial-temporal dispersion of airborne nanomaterials during the use of spray consumer products and estimated the level of consumer inhalation exposure. A total of eight spray products including five propellant and three pump types were selected to evaluate the dispersion of airborne nanoparticles across time and space in a cleanroom which could control the background particles. Four products were advertised to contain silver and one contained titanium nanoparticles, while three products were specified no ENM but as being manufactured through the use of nanotechnology. We used direct-reading instruments with a thermodesorber unit to measure the particles (number, mass, surface area), as well as filter sampling to examine physicochemical characteristics. Sampling was conducted simultaneously at each location (1 m, near-field; 2, 3 m, far-field) by distance from the source. We estimated the inhaled doses at the breathing zone, and the doses deposited in each part of the respiratory tract using the experimental data and mathematical models. Nanoparticles released from the propellant sprays persisted in the air and dispersed over a large distance due to their small size (1466–5565 particles/cm<SUP>3</SUP>). Conversely, the pump sprays produced larger droplets that settled out of the air relatively close to the source, so the concentration was similar to background level (<200 particles/cm<SUP>3</SUP>). The estimates of inhalation exposure also suggested that exposure to nanoparticles was greater with propellant sprays (1.2 × 10<SUP>8</SUP> ± 4.0 × 10<SUP>7</SUP> particles/kgbw/day) than pump sprays (2.7 × 10<SUP>7</SUP> ± 6.5 × 10<SUP>6</SUP> particles/kgbw/day). We concluded that the propellant sprays create a higher risk of exposure than the pump sprays.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2017/esthag.2017.51.issue-13/acs.est.7b00211/production/images/medium/es-2017-00211d_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es7b00211'>ACS Electronic Supporting Info</A></P>
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Park, Dae-Young,Lee, Junyeop,Park, Intae,Choi, Dongwon,Lee, Sunju,Song, Sukhyun,Hwang, Yoonha,Hong, Ki Yong,Nakaoka, Yoshikazu,Makinen, Taija,Kim, Pilhan,Alitalo, Kari,Hong, Young-Kwon,Koh, Gou Young American Society for Clinical Investigation 2014 The Journal of clinical investigation Vol.124 No.9
<P>Schlemm's canal (SC) is a specialized vascular structure in the eye that functions to drain aqueous humor from the intraocular chamber into systemic circulation. Dysfunction of SC has been proposed to underlie increased aqueous humor outflow (AHO) resistance, which leads to elevated ocular pressure, a factor for glaucoma development in humans. Here, using lymphatic and blood vasculature reporter mice, we determined that SC, which originates from blood vessels during the postnatal period, acquires lymphatic identity through upregulation of prospero homeobox protein 1 (PROX1), the master regulator of lymphatic development. SC expressed lymphatic valve markers FOXC2 and integrin α9 and exhibited continuous vascular endothelial-cadherin (VE-cadherin) junctions and basement membrane, similar to collecting lymphatics. SC notably lacked luminal valves and expression of the lymphatic endothelial cell markers podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1). Using an ocular puncture model, we determined that reduced AHO altered the fate of SC both during development and under pathologic conditions; however, alteration of VEGF-C/VEGFR3 signaling did not modulate SC integrity and identity. Intriguingly, PROX1 expression levels linearly correlated with SC functionality. For example, PROX1 expression was reduced or undetectable under pathogenic conditions and in deteriorated SCs. Collectively, our data indicate that PROX1 is an accurate and reliable biosensor of SC integrity and identity.</P>