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Effect of Physical Parameterization Schemes on Track and Intensity of Cyclone LAILA Using WRF Model
Radhika D. Kanase,P. S. Salvekar 한국기상학회 2015 Asia-Pacific Journal of Atmospheric Sciences Vol.51 No.3
The objective of the present study is to investigate in detail the sensitivity of cumulus parameterization (CP), planetary boundary layer (PBL) parameterization, microphysics parameterization (MP) on the numerical simulation of severe cyclone LAILA over Bay of Bengal using Weather Research & Forecasting (WRF) model. The initial and boundary conditions are supplied from GFS data of 1o × 1o resolution and the model is integrated in three ‘twoway’ interactive nested domains at resolutions of 60 km, 20 km and 6.6 km. Total three sets of experiments are performed. First set of experiments include sensitivity of Cumulus Parameterization (CP) schemes, while second and third set of experiments is carried out to check the sensitivity of different PBL and Microphysics Parameterization (MP) schemes. The fourth set contains initial condition sensitivity experiments. For first three sets of experiments, 0000 UTC 17 May 2010 is used as initial condition. In CP sensitivity experiments, the track and intensity is well simulated by BettsMiller-Janjic (BMJ) schemes. The track and intensity of LAILA is very sensitive to the representation of large scale environmental flow in CP scheme as well as to the initial vertical wind shear values. The intensity of the cyclone is well simulated by YSU scheme and it depends upon the mixing treatment in and above PBL. Concentration of frozen hydrometeors, such as graupel in WSM6 MP scheme and latent heat released during auto conversion of hydrometeors may be responsible for storm intensity. An additional set of experiments with different initial vortex intensity shows that, small differences in the initial wind fields have profound impact on both track and intensity of the cyclone. The representation of the mid-tropospheric heating in WSM6 is mainly controlled by amount of graupel hydrometeor and thus might be one of the possible causes in modulating the storm’s intensity.
Effect of thymectomy on the female reproductive cycle in neonatal guinea pigs
Murali, P.,Radhika, J.,Alwin, D. The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.1
Objective: The appropriate function of the hypothalamic-pituitary-gonadal axis is essential for maintaining proper reproductive function. In female mammals, the hypothalamic-pituitary-gonadal axis regulates reproductive changes that take place in the estrus cycle and are necessary for successful reproduction. This study was conducted to investigate the effect of thymectomy on the estrus cycle in neonatally thymectomized guinea pigs. Methods: In this study, 12 female guinea pigs, six thymectomized and six sham-operated, were studied. The effects of neonatal thymectomy at 5-7 days of age on parameters of the reproductive axis were examined in female guinea pigs. Gonadotropin and 17β-estradiol levels were assessed at regular intervals (days 0, 3, 6, 9, 12, and 15) of the estrus cycle, and the time of vaginal opening in the thymectomized and shamoperated guinea pigs was determined. Results: Significant reductions in gonadotropins and 17β-estradiol levels during estrus cycle were found in neonatally thymectomized female guinea pigs compared to sham-operated guinea pigs. Conclusion: The results of this study underscore the importance of the thymus in the neonatal period for normal female reproductive function.
Expression, Purification, and Characterisation of Nesiritide Using an E. coli Expression System
Laxmi S. Rao,Milind P. Niphadkar,Dinesh Paliwal,Rakesh Shekhawat,Aruna G. Khare,S. Uma,Priti Thakur,Anjali Chutke,Neelesh Surlikar,Radhika Samant,Sagar Zawar 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.4
Nesiritide, the recombinant human brain natriuretic peptide, is involved in the regulation of cardiovascular homeostasis and has been approved for treatment of patients with congestive heart failure. We prepared a synthetic cDNA construct of Nesiritide to generate a fusion protein with an affinity handle and 41 amino acid peptide of β-galactosidase. The fusion protein was expressed mainly in the inclusion bodies and accounted for approximately 20% of total cellular protein. After purification by Ni-IDA affinity chromatography and renaturation, the fusion protein was cleaved with purified recombinant enterokinase. Nesiritide was purified by pH precipitation/ion exchange chromatography followed by source phenyl chromatography to obtain protein with > 99% purity (determined by RPHPLC)and a mass of 3,464 Daltons. The potency (ED_(50))of the purified protein was equivalent to that of Natrecor (Innovator formulation). Analytical methods were developed to identify oxidised, reduced and other related impurities. The expression strategy described in this work allows the convenient generation of high yield Nesiritide and enabled ease of purification.
Subrahamanyam, D. Bala,Rani, S. Indira,Ramachandran, Radhika,Kunhikrishnan, P. K. The Korean Society of Oceanography 2008 Ocean science journal Vol.43 No.4
In this article, we describe a simple yet effective method for insertion of observational datasets in a mesoscale atmospheric model used in one-dimensional configuration through Nudging. To demonstrate the effectiveness of this technique, vertical profiles of meteorological parameters obtained from GLASS Sonde launches from a tiny island of Kaashidhoo in the Republic of Maldives are injected in a mesoscale atmospheric model - Advanced Regional Prediction System (ARPS), and model simulated parameters are compared with the available observational datasets. Analysis of one-time nudging in the model simulations over Kaashidhoo show that incorporation of this technique reasonably improves the model simulations within a time domain of +6 to +12 Hrs, while its impact on +18 Hrs simulations and beyond becomes literally null.
D. Bala Subrahamanyam,S. Indira Rani,Radhika Ramachandran,P. K. Kunhikrishnan 한국해양과학기술원 2008 Ocean science journal Vol.43 No.4
In this article, we describe a simple yet effective method for insertion of observational datasets in a mesoscale atmospheric model used in one-dimensional configuration through Nudging. To demonstrate the effectiveness of this technique, vertical profiles of meteorological parameters obtained from GLASS Sonde launches from a tiny island of Kaashidhoo in the Republic of Maldives are injected in a mesoscale atmospheric model - Advanced Regional Prediction System (ARPS), and model simulated parameters are compared with the available observational datasets. Analysis of one-time nudging in the model simulations over Kaashidhoo show that incorporation of this technique reasonably improves the model simulations within a time domain of +6 to +12 Hrs, while its impact on +18 Hrs simulations and beyond becomes literally null. In this article, we describe a simple yet effective method for insertion of observational datasets in a mesoscale atmospheric model used in one-dimensional configuration through Nudging. To demonstrate the effectiveness of this technique, vertical profiles of meteorological parameters obtained from GLASS Sonde launches from a tiny island of Kaashidhoo in the Republic of Maldives are injected in a mesoscale atmospheric model - Advanced Regional Prediction System (ARPS), and model simulated parameters are compared with the available observational datasets. Analysis of one-time nudging in the model simulations over Kaashidhoo show that incorporation of this technique reasonably improves the model simulations within a time domain of +6 to +12 Hrs, while its impact on +18 Hrs simulations and beyond becomes literally null.