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The state of the art of osseointegration for limb prosthesis
A. L. Overman,J. A. Forsberg 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
Osseointegration (OI) is the direct attachment of bone onto a titanium implant. Recently, the term is used to describe “transdermal”implants that allow an external prosthesis to be connected directly to the skeleton. This technology eliminates thechallenges of conventional socket-based prostheses, such as skin breakdown and poor fi t, which are common in patientswith major extremity amputations. Osseointegration patients demonstrate encouraging improvements in quality of life andfunction. Patients report improvement in prosthetic use, prosthetic mobility, global health, and pain reduction on a varietyof clinical assessment tools. Various implants have been developed for osseointegration for amputees. These implants usea variety of fi xation strategies and surface augments to allow for successful integration into the host bone. Regardless ofdesign, all OI implants face similar challenges, particularly infections. Other challenges include the inability to determinewhen integration has occurred and the inability to detect loss of integration. These challenges may be met by incorporatingsensing systems into the implants. The percutaneous nature of the metal devices can be leveraged so that internal sensors neednot be wireless, and can be interrogated by external monitoring systems, thus providing crucial, real-time information aboutthe state of the implant. The purpose of this review is to (1) review the basic science behind osseointegration, (2) providean overview of current implants, practice patterns, and clinical outcomes, and (3) preview sensor technologies which mayprove useful in future generations of transdermal orthopaedic implants.
Slutskyy, Yuriy,Jamison, Christopher R.,Zhao, Peng,Lee, Juyeol,Rhee, Young Ho,Overman, Larry E. American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.21
<P>A short enantioselective synthesis of 6-substituted cis-2,8-dioxabicyclo[3.3.0]octan-3-ones is described. The pivotal step is coupling of a tertiary radical generated directly from a tertiary alcohol with a 3-chloro-5-alkoxybutenolide. This strategy is applied toward scalable 14-15 step syntheses of three rearranged spongian diterpenoids: cheloviolenes A and B and dendrillolide C.</P>
Garnsey, Michelle R.,Slutskyy, Yuriy,Jamison, Christopher R.,Zhao, Peng,Lee, Juyeol,Rhee, Young Ho,Overman, Larry E. American Chemical Society 2018 Journal of organic chemistry Vol.83 No.13
<P>The development of a convergent fragment coupling strategy for the enantioselective total syntheses of a group of rearranged spongian diterpenoids that harbor the <I>cis</I>-2,8-dioxabicyclo[3.3.0]octan-3-one unit is described. The key bond disconnection relies on a late-stage fragment coupling between a tertiary carbon radical and an electron-deficient alkene to unite two ring systems and form two new stereocenters, one of which is quaternary, in a stereoselective and efficient manner. This strategy is applied toward scalable 14-15 step syntheses of three rearranged spongian diterpenoids, cheloviolenes A and B, and dendrillolide C.</P> [FIG OMISSION]</BR>