The admission of Japan and the two Koreas to membership in the United Nations

Nurlan Ospanov 인하대학교 사회과학연구소 2014 인하사회과학논총 Vol.29 No.-

After creation of the United Nations all independent countries, which were not members of the Organization, sought to join the United Nations. Japan and the two Koreas also applied for membership. When the above-mentioned states submitted their applications it was period of the beginning of the Cold War between the United States and the Soviet Union. Because of the tensions between two superpowers, the admission of Japan and North and South Korea was very difficult. It took five years for Japan to be admitted to the UN, while North and South Korea spent 43 years to be members of the organization.

Correlation Calculation of Forming the Model Energy-Efficient Production

Murat M. Ospanov,Assel T. Uskelenova,Kairatbek Kh. Shadiyev 대한산업공학회 2020 Industrial Engineeering & Management Systems Vol.19 No.1

The basic principle of any industrial cooperation is first to build an effective interaction between the cost of production and the potential profit from its implementation. If the sale of products is unstable or cannot always be admitted to the market, there is often a decrease in the activity of the enterprise. At the same time, competitive advantages are gained by the production, which forms its activity on the principles of cost reduction and increase of output per unit of cost. The aim of the article is to create a model of energy efficiency and show aspects of its application in industry. To accomplish this task, the article uses the price research method. The novelty of the work is determined by the fact that as a result of research, the article shows the aspects of the formation of effective industrial cooperation based on the integration of production into the global economic environment, which in turn is aimed at increasing the competitiveness throughout the world. The practical significance of the study is determined by the fact that it allows creating a model of transition to the innovative forms of production based on energy saving.

Control of Fuzzy Technological Objects Based on Mathematical Models

Y.A. Ospanov,B.B. Orazbayev,K.N. Orazbayeva,T. Gancarczyk,A.K. Shaikhanova 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10

This paper proposes methods for the development of mathematical models and for the control of operation modes of technological objects in oil refinery in face of uncertainty based on fuzzy information. The mathematical formulation of the problem of decision-making on controlling modes, which are solved on the basis of mathematical modeling, is formalized and obtained. By using the example of the problem of decision-making on optimal operation modes of technological complex for the benzene production and based on the methods of fuzzy mathematics an algorithm of its solution is developed. The initial problem is formalized as a problem of decision-making in the fuzzy environment, since the investigated object is characterized by multicriteriality and frequently functions in a fuzzy environment. The mathematical formulation of the problem of object’s mode selection in the fuzzy environment and the heuristic algorithm of its solution is obtained by modifying various optimality principles based on methods of the fuzzy sets theory.

BRCA1 and TP53 Gene-Mutations: Family Predisposition and Radioecological Risk of Developing Breast Cancer

Apsalikov, Bakytbek,Manambaeva, Zukhra,Ospanov, Erlan,Massabayeva, Meruyert,Zhabagin, Kuantkan,Zhagiparova, Zhanar,Maximov, Vladymir,Voropaeva, Elena,Apsalikov, Kazbek,Belikhina, Tatiana,Abdrahmanov, Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Frequencies of polymorphisms of genes BRCA1 and ТР53 in breast cancer (BC) patients with a BC family history and radiation history were assessed and compared in the Semey region of Kazakhstan. The study included 60 women directly irradiated by the activities of the Semipalatinsk test site with a calculated effective equivalent dose of 500 mSv and their first generation descendants (group BC+Her+Exp); 65 women with family BC and absence of radiological history - the effective equivalent dose due to anthropogenic sources not exceeding 50 mSv (group BC+Her-Exp). The comparison group consisted of 65 women patients with breast cancer without family and radiological history (BC-Her-Exp). The control group comprised 60 women without breast cancer and without family and radiological history (nonBC). We carried out the genotyping of the polymorphisms c.2311T>C, c.4308T>C and 5382insC of the BRCA1 gene and rs1042522 of the ТР53 gene. The frequency of the polymorphism c.2311T>C was significantly higher in patients of the group BC+Her+Exp than in healthy women, and of the polymorphism 5382insC in BC+Her+Exp compared to all other groups. The frequency of the rs1042522 polymorphism of ТР53 was significantly higher in all groups of patients with breast cancer compared with the control group. Differences between groups of women with breast cancer were significant only in BC+Her+Exp vs. BC+Her-Exp. Combinations of polymorphisms of the genes BRCA1 and TP53 predominated in women with a family and radiological history.

Pediatric Liver Transplantation Program in Kazakhstan

( Yermakhan Assylkhanuly ),( Dulat Mustafinov ),( Damir Dzhenalayev ),( Marat Ospanov ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Living donor liver transplantation has become a cornerstone for the treatment of children with end-stage hepatic dysfunction, especially in Kazakhstan with low rates of organ from deceased donors. In our center, 8 pediatric living donor liver transplantations we carried out since 2014. Patients between the ages of 0 to 5 years. The indications for liver transplantation in our patients were biliary atresia. Methods: The mean hospitalization time of our patients was 25 days and the mean stay in the intensive care unit was 8 days. The Child-Pugh score was C in 2 of our patients, B in 5 patients, and A in 1 patient. The donor age ranged from 27 to 41 years, and the weight ranged from 62 to 78 kg, mothers being the donors in a majority of these. As most children require only a left lateral segment graft, the morbidity and risks to the donor are much less than those donating their right lobes. Living donor transplants are ideally suited to children as it allows for a planned procedure, allows for a near optimal size graft for the child, reduces the risk for the donor, and the incidence of rejection is reduced. Results: The main complications after pediatric liver transplantation were infections and surgical complications including (biliary complications). We encountered biliary complications in 2 of the 8 patients and we performed surgical revision due to anastomosis leakage in 1 patient. Our immune suppression protocol is based on a combination of steroid and tacrolimus. MMF is also used as a second maintenance agent in addition to tacrolimus in children who have had a documented rejection episode. Conclusions: Infections and biliary complications were the most common outcome occurring in children after LT. Advances in post-transplant care and monitoring of the recipients, technical refinements enable the better results.

PE-105 Successful Single-Stage Extended Right Hemihepatectomy with Low Anterior Resection of the Rectum in Patients with Colorectal Cancer with Liver Metastases

( A. Smagulov ),( Tleuliev B. K ),( Kurbanbaev A. R ),( Ospanov Sh. E ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Colorectal cancer (CRC) occupies the 4th place in the structure of cancer morbidity in Kazakhstan. From 35 to 57% of patients with colorectal cancer with primary treatment have metastases to the liver. However, active surgical treatment of metastatic liver invasion allows achieving 5-year survival in 27-47% of patients. Methods: We present the clinical observation of successful surgical treatment of rectal cancer with liver metastases with simultaneous execution of extended right hepatectomy and "low" anterior rectal resection. Patient E., 54 years old, male. From anamnesis: the above complaints are noted within 6 months. Ultrasonography of the abdominal cavity revealed a focal lesion in the right lobe of the liver, with a colonoscopy: in the middle-ampullar rectal section, a tumor up to 5 cm in length is located 8 cm above the anus, which closes the colon lumen of the gut by 2/3; the result of a biopsy: moderately differentiated adenocarcinoma. By PET - no other metastatic problems. Results: Was performed extended right hepatectomy (cholecystectomy) and "low" anterior rectal resection. After operation recommended adjuvant chemotherapy. At the control examination 3 months later after the operative treatment the condition is satisfactory, the laboratory parameters are within the norm. With ultrasound of the abdominal cavity signs of progression of the disease is not revealed. Conclusions: Thus, the using of one-step operations on the primary tumors of CRC and liver metastatically lesions makes it possible to perform the surgical treatment in a shorter time and earlier to start adjuvant chemotherapy. With hepatic metastases of CRC, it is justified to perform extended liver resections.