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Oky Maeng,백상기,손원석,정종경,Kyu-Sun Lee,Young-Ha Lee,유욱준,차광호 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.5
In Drosophila, broad complex, tramtrack, bric à brac (BTB)/ poxvirus and zinc finger (POZ) transcription factors are essential regulators of development. We searched the Drosophila genome for BTB/POZ-ZF domains and discovered an unknown Drosophila gene, dPLZF, which encodes an orthologue of human PLZF. We then characterized the biological function of the dPLZF via genetic interaction analysis. Ectopic expression of dPLZF in the wing induced extra vein formation during wing development in Drosophila. Genetic interactions between dPLZF and Ras or extracellular signal-regulated kinase (ERK) significantly enhanced the formation of vein cells. On the other hand, loss-of-function mutations in dPLZF resulted in a dramatic suppression of the extra and ectopic vein formation induced by elevated Ras/ERK signaling. Moreover, dPLZF activity upregulated the expression of rhomboid (rho) and spitz, which perform crucial functions in vein cell formation in the developing wing. These results indicate that dPLZF is a transcription factor controlled by the Ras/ERK signaling pathway, which is a prominent regulator of vein cell formation during wing development in Drosophila.
맹옥희,김용찬,김영상,백상기,이혜영 충남대학교 생물공학연구소 2002 생물공학연구지 Vol.8 No.2
Nitric oxide (NO) and NO synthases have become an important research topic in cellular and molecular biology. NO is produced by many mammalian cells and performs a broad spectrum of signaling functions in the immunological, neurological and vascular system. NO has multiple molecular targets. It can not only directly influence the activity of transcription factors but also modulate upstream signaling cascades as well as the processing of the primary gene products. It was hypothesized that NO production induced a specific set of henetic programs that might serve to alter cellular metabolism in macrophage. A technique called suppression subtractive hybridization (SSH) was adopted to identify genes differentially expressed in NO-stimulated cells.
Microarray Study of Genes Differentially Modulated in Response to Nitric Oxide in Macrophages
Nan, Xuehua,Maeng, Oky,Shin, Hyo-Jung,An, Hyun-Jung,Yeom, Young-Il,Lee, Hay-Young,Paik, Sang-Gi The Korean Society for Integrative Biology 2008 Animal cells and systems Vol.12 No.1
Nitric oxide(NO) has been known to play important roles in numerous physiologic processes including neurotransmission, vasorelaxation, and cellular apoptosis. Using a mouse cDNA gene chip, we examined expression patterns and time course of NO-dependent genes in mouse macrophage RAW264.7 cells. Genes shown to be upregulated more than two fold or at least at two serial time points were further selected and validated by RT-PCR. Finally, 81 selected genes were classified by function as signaling, apoptosis, inflammation, transcription, translation, ionic homeostasis and metabolism. Among those, genes related with signaling, apoptosis and inflammation, such as guanylate cyclase 1, soluble, alpha3(Gucy1a3); protein kinase C, alpha($Pkc{\alpha}$); lymphocyte protein tyrosine kinase(Lck); BCL2/adenovirus E1B 19 kDa-interacting protein(Bnip3); apoptotic protease activating factor 1(Apaf1); X-linked inhibitor of apoptosis(Xiap); cyclin G1(Ccng1); chemokine(C-C motif) ligand 4(Ccl4); B cell translocation gene 2, anti-proliferative(Btg2); lysozyme 2(Lyz2); secreted phosphoprotein 1(Spp1); heme oxygenase(decycling) 1(Hmox1); CD14 antigen(Cd14); and granulin(Grn) may play important roles in NO-dependent responses in murine macrophages.
Microarray Study of Genes Differentially Modulated in Response to Nitric Oxide in Macrophages
Xuehua Nan,Oky Maeng,신효정,안현정,염영일,이혜영,백상기 한국통합생물학회 2008 Animal cells and systems Vol.12 No.1
Nitric oxide (NO) has been known to playimportant roles in numerous physiologic processes includingUsing a mouse cDNA gene chip, we examined expressionpatterns and time course of NO-dependent genes in mousemacrophage RAW264.7 cells. Genes shown to be up-regulated more than two fold or at least at two serial timepoints were further selected and validated by RT-PCR.Finally, 81 selected genes were classified by function assignaling, apoptosis, inflammation, transcription, translation,ionic homeostasis and metabolism. Among those, genesrelated with signaling, apoptosis and inflammation, such asguanylate cyclase 1, soluble, alpha3 (Gucy1a3 ); proteinkinase C, alpha (Pkcα(Lck); BCL2/adenovirus E1B 19 kDa-interacting protein(Bnip3); apoptotic protease activating factor 1 (Apaf1); X-linked inhibitor of apoptosis (Xiap); cyclin G1 (Ccng1);chemokine (C-C motif) ligand 4 (Ccl4); B cell translocationgene 2, anti-proliferative (Btg2); lysozyme 2 (Lyz2); secretedphosphoprotein 1 (Spp1); heme oxygenase (decycling) 1(Hmox1); CD14 antigen (Cd14); and granulin (Grn) mayplay important roles in NO-dependent responses in murinemacrophages.