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Okazawa, Atsushi,Akamatsu, Miki,Ohoka, Akira,Nishiwaki, Hisashi,Cho, Won Jea,Nakagawa, Yoshiaki,Nishimura, Keiichiro,Ueno, Tamio 전남대학교 약품개발연구소 1998 약품개발연구지 Vol.7 No.1
The binding activity of imidacloprid and related compounds to nicotinic acetylcholine receptors (nAChR) of house flies was measured by use of radioactive χ-bungarotoxin as a ligand. Variations in the activity were examined three-dimensionally using comparative molecular field analysis (CoMFA). The CoMFA results suggest that one conformer among the four stable ones is active and provide support for one of the proposed binding models for this class of compound. in which the nitrogen atom of the pyridine ring and the nitrogen atom at the 1-position of the imidazolidine ring interact with the hydrogen-donating and electron-rich sites of nAChR. respectively. The CoMFA field map showed that the nitroimino moiety and a portion of the imidazolidine ring were mainly surrounded by a sterically and electrostatically sensitive region of nAChR.
Amerasian Children of GI Town : A Legacy of U.S. Militarism in South Korea
Okazawa-Rey, Margo Ewha Womans University Press 1997 Asian Journal of Women's Studies(AJWS) Vol.3 No.1
This paper looks at the effects of the U.S. military presence in South Korea, specifically, prostitution in communities around the military bases, on Amerasian children and their Korean mothers. The data were gathered from a series of interviews with both groups of people, feminist activists addressing the problem of U.S. militarism in South Korea, and social service providers working with Amerasian children. It is argued that the issues discussed in this paper need to be seen in terms of the U.S. military as an institution, the militarized masculinity which it generates, and women's socio-economic position. Using the analytical lenses of gender, race, class, and nation, a call is made for activist scholarship by feminists to address this problem.
Bypass, homotopy path and local iteration to compute the stability point
Fujii, Fumio,Okazawa, Shigenobu Techno-Press 1997 Structural Engineering and Mechanics, An Int'l Jou Vol.5 No.5
In nonlinear finite element stability analysis of structures, the foremost necessary procedure is the computation to precisely locate a singular equilibrium point, at which the instability occurs. The present study describes global and local procedures for the computation of stability points including bifurcation points and limit points. The starting point, at which the procedure will be initiated, may be close to or arbitrarily far away from the target point. It may also be an equilibrium point or non-equilibrium point. Apart from the usual equilibrium path, bypass and homotopy path are proposed as the global path to the stability point. A local iterative method is necessary, when it is inspected that the computed path point is sufficiently close to the stability point.
Seiji Mabuchi,Fumiaki Isohashi,Mika Okazawa,Fuminori Kitada,Shintaro Maruoka,Kazuhiko Ogawa,Tadashi Kimura 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.1
Objective: To evaluate the efficacy and toxicity of paclitaxel plus carboplatin (TC)-based concurrent chemoradiotherapy (CCRT) followed by consolidation chemotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage IIIB/IVA cervical cancer patients. Methods: We reviewed the medical records of FIGO stage IIIB/IVA cervical cancer patients (n=30) who had been intended to be treated with TC-based CCRT followed by consolidation chemotherapy (TC-CCRT-group) from April 2012–May 2016. Patients who had been treated with CCRT involving a single platinum agent (CCRT-group; n=52) or definitive radiotherapy alone (RT-group; n=74) from January 1997–September 2012 were also identified and used as historical controls. Survival was calculated using the Kaplan-Meier method and compared using the log-rank test. Results: Of the 30 patients included in the TC-CCRT-group, 22 patients (73.3%) completed the planned TC-based CCRT. The most frequently observed acute grade 3/4 hematological toxicities were leukopenia and neutropenia, and diarrhea was the most common acute grade 3/4 non-hematological toxicity. After a median follow-up of 35 months, 9 patients (30.0%) had developed recurrent disease. The patients’ estimated 3-year progression-free survival (PFS) and overall survival (OS) rates were 67.9% and 90.8%, respectively. In comparisons with historical control groups, the survival outcomes of TC-CCRT-group was significantly superior to CCRT-group in terms of OS (p=0.011) and significantly superior to RT-group in terms of both PFS (p=0.009) and OS (p<0.001). Conclusion: TC-based CCRT followed by consolidation chemotherapy is safe and effective. A randomized controlled study needs to be conducted to further evaluate the efficacy of this multimodal approach in this patient population.
Koji Matsuo,Seiji Mabuchi,Mika Okazawa,Mahiru Kawano,Hiromasa Kuroda,Shoji Kamiura,Tadashi Kimura 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.1
Objective: Presence of high-risk factor in cervical cancer is known to be associated with decreased survival outcomes. However, the significance of multiple high-risk factors in early-stage cervical cancer related to survival outcomes, recurrence patterns, and treatment implications is not well elucidated. Methods: A retrospective study was conducted for surgically treated cervical cancer patients (stage IA2–IIB, n=540). Surgical-pathological risk factors were examined and tumors expressing ≥1 high-risk factors (nodal metastasis, parametrial involvement, or positive surgical margin) were eligible for analysis (n=177, 32.8%). Survival analysis was performed based on the number of high-risk factors and the type of adjuvant therapy. Results: There were 68 cases (38.4%) expressed multiple high-risk factors (2 high-risk factors: n=58, 32.8%; 3 high-risk factors: n=10, 5.6%). Multiple high-risk factors remained an independent prognosticator for decreased survival outcomes after controlling for age, histology, stage, and treatment type (disease-free survival: hazard ratio [HR], 2.34; p=0.002; overall survival: HR, 2.32; p=0.007). Postoperatively, 101 cases (57.1%) received concurrent chemoradiotherapy (CCRT) and 76 cases (42.9%) received radiotherapy (RT) alone. CCRT was beneficial in single high-risk factor cases: HRs for CCRT over RT alone for cumulative risk of locoregional and distant recurrence, 0.27 (p=0.022) and 0.27 (p=0.005), respectively. However, tumor expressing multiple high-risk factors completely offset the benefit of CCRT over RT alone for the risk of distant recurrence: HR for locoregional and distant recurrence, 0.31 (p=0.071) and 0.99 (p=0.980), respectively. Conclusion: Special consideration for the significance of multiple high-risk factors merits further investigation in the management of surgically treated early-stage cervical cancer.
Tamaki Tanaka,Kazuhiro Takehara,Natsumi Yamashita,Mika Okazawa-Sakai,Kazuya Kuraoka,Norihiro Teramoto,Kenichi Taguchi,Katsushige Yamashiro,Hidenori Kato,Tomoya Mizunoe,Rie Suzuki,Dan Yamamoto,Arisa Ue 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Objective: To clarify the frequency of deficient mismatch repair (dMMR) in Japanese ovarian cancer patients, we examined microsatellite instability (MSI) status and immunohistochemistry (IHC) subtypes, including endometrioid carcinoma (EMC), clear cell carcinoma (CCC), or a mixture of both (Mix). Methods: We registered 390 patients who were diagnosed with EMC/CCC/Mix between 2006 and 2015 and treated at seven participating facilities. For 339 patients confirmed eligible by the Central Pathological Review Board, MSI, IHC, and MutL homolog 1 methylation analyses were conducted. The tissues of patients with Lynch syndrome (LS)-related cancer histories, such as colorectal and endometrial cancer, were also investigated. Results: MSI-high (MSI-H) status was observed in 2/217 CCC (0.9%), 10/115 EMC (8.7%), and 1/4 Mix (25%). Additionally, loss of MMR protein expression (LoE-MMR) was observed in 5/219 (2.3%), 16/115 (14.0%), and 1/4 (25%) patients with CCC, EMC, and Mix, respectively. Both MSI-H and LoE-MMR were found significantly more often in EMC (p<0.001). The median (range) ages of patients with MMR expression and LoE-MMR were 54 (30–90) and 46 (22–76) (p=0.002), respectively. In the multivariate analysis, advanced stage and histological type were identified as prognostic factors. Conclusion: The dMMR rate for EMC/CCC was similar to that reported in Western countries. In Japan, it is assumed that the dMMR frequency is higher because of the increased proportion of CCC.
Yuichi Tomiki,Jun Aoki,Shunsuke Motegi,Rina Takahashi,Toshiaki Hagiwara,Yu Okazawa,Kosuke Mizukoshi,Masaya Kawai,Shinya Munakata,Shun Ishiyama,Kiichi Sugimoto,Kazuhiro Sakamoto 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.6
Background/Aims: Sclerotherapy with aluminum potassium sulfate and tannic acid (ALTA) has a potent effect on internalhemorrhoids. In this retrospective study, we compared the effects of endoscopic ALTA therapy and standard ALTA therapy. Methods: We investigated patients who underwent treatment for internal hemorrhoids at our institution between 2014 and 2016. Theywere divided into a standard ALTA group (n=33, treated using proctoscopy) and an endoscopic ALTA group (n=48). We compared theclinical findings between the 2 groups. Results: There were no intergroup differences in background factors. The mean ALTA dose was 21.9±7.2 mL and 17.8±3.4 mL inthe standard and endoscopic ALTA groups, respectively (p<0.01). Adverse events occurred in 4 patients (12.1%) from the standardALTA group and 6 patients (12.5%) from the endoscopic ALTA group. In both groups, the patients reported good satisfaction withthe therapeutic effect at 1 month after the procedure. Hemorrhoids recurred in 2 patients (6.3%) from the standard ALTA group and 4patients (8.3%) from the endoscopic ALTA group. Conclusions: Endoscopic ALTA sclerotherapy is equivalent to standard ALTA therapy in terms of efficacy, adverse events, andrecurrence. Therefore, it is a useful non-surgical option for patients with internal hemorrhoids who prefer a less invasive treatment.
Small-Angle X-Ray Scattering Study on PVA/Fe3O4 Magnetic Hydrogels
Sunaryono,Ahmad Taufiq,Edy Giri Rahman Putra,Atsushi Okazawa,Isao Watanabe,Norimichi Kojima,Supagorn Rugmai,Siriwat Soontaranon,Mohammad Zainuri,Triwikantoro,Suminar Pratapa,Darminto 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.3
A synchrotron small-angle X-ray scattering (SAXS) study on PVA/Fe3O4 magnetic hydrogels has been performed to investigate the effect of clustering on their magnetic properties. The hydrogels were prepared through freezing–thawing (F–T) processes. The structure, morphology and magnetic properties of magnetite (Fe3O4) nanoparticles (NPs) were investigated using X-ray diffractometry (XRD), transmission electron microscopy (TEM) and a superconducting quantum interference device (SQUID) magnetometer, respectively. In this study, SAXS data were used to reveal the structural dimensions of the magnetite and its distribution in the polymer-rich PVA and magnetic hydrogels. As calculated using the Beaucage and Teubner–Strey models, the average of the structural dimensions of the PVA hydrogels was 3.9 nm (crystallites), while the average distance between crystallites was approximately 18 nm. Further analysis by applying a two-lognormal distribution showed that the magnetite NPs comprised secondary particles with a diameter of 9.6 nm that were structured by primary particles (~3.2 nm). A two-lognormal distribution function has also been used in describing the size distributions of magnetite NPs in magnetic hydrogels. The clusters of magnetite NPs in the magnetic hydrogels are significantly reduced from 30.4 nm to 12.8 nm with decreasing concentration of the NPs magnetite from 15 wt.% to 1 wt.%. The saturation magnetization values of the magnetite NPs, the 15% and 1% magnetic hydrogels were 34.67 emu/g, 6.52 emu/g and 0.37 emu/g, respectively.