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돼지 Melanocortin Receptor 1(MC1R) 대립유전자 3의 신규 유전변이 탐색
조인철,정용환,정진관,성필남,오운용,고문석,김병우,이정규,전진태 한국동물자원과학회 2004 한국축산학회지 Vol.46 No.1
This study was conducted to investigate novel genetic variations of MCIR/R*3 allele. In general, white spotting or white belt on a black backgroud in pigs is determined by the E^(p) allele at the MICR/Extention locus. E^(p) shares a frameshift mutation with the E^(p) allele for dominant black color. An oligonucleotide primer set was designed to amplify complete coding sequence of the porcine MICR gene. The MICR coding sequences obtained from five breeds those were Landrace(white), Yorkshire(white), Hampshire(belt), Berkshire(spot) and Jeju native black pigs(black), were used for this study. A multiple sequence alignment of the MICR coding region using Clustal W was performed. The total length of the MCIR coding sequence ranged from 963 to 966 base pairs(bp) among the selected breeds. The sequence analysis of the complete coding region of MICR was revealed that Hampshire and Jeju native black pig have 3 cytosines deletion and Birkshire has 2 cytosines deletion at codon 23(nt68) in Extention loci. Besides the finding, there were three different missense mutations and a frameshift mutation in the MCIR coding region.
A tetradentate Ni(II) complex cation as a single redox couple for non-aqueous flow batteries
Kim, Hyun-seung,Yoon, Taeho,Jang, Jihyun,Mun, Junyoung,Park, Hosang,Ryu, Ji Heon,Oh, Seung M. Elsevier 2015 Journal of Power Sources Vol.283 No.-
<P><B>Abstract</B></P> <P>Nickel(II)-1,4,8,11-tetraazacyclotetradecane is examined as a possible single redox couple for non-aqueous flow batteries. The nickel complex cation is reduced at −1.81 V (<I>vs</I>. Fc/Fc<SUP>+</SUP>) and oxidized at 0.74 V, showing that this tetradentate Ni(II) complex cation can be used as a single redox couple that offers a cell voltage of 2.55 V. The maximum solubility is 0.4 M in 1.0 M tetraethylammonium tetrafluoroborate dissolved in a mixed solvent of ethylene carbonate and propylene carbonate. When tested in a non-flowing cell, this single redox couple exhibits a very stable cycle performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nickel(II)-1,4,8,11-tetraazacyclotetradecane is evaluated as a single redox couple for non-aqueous flow battery. </LI> <LI> Ni(cyclam)[ClO<SUB>4</SUB>]<SUB>2</SUB> shows a high solubility (0.4 M) in non-aqueous electrolyte. </LI> <LI> Ni(cyclam)<SUP>2+</SUP> offers a high working voltage (2.55 V) as a single redox couple. </LI> <LI> Ni(cyclam)<SUP>2+</SUP> is chemically and electrochemically stable. </LI> </UL> </P>
Kim, Hyun-seung,Lee, Keon-Joon,Han, Young-Kyu,Ryu, Ji Heon,Oh, Seung M. Elsevier 2017 Journal of Power Sources Vol.348 No.-
<P><B>Abstract</B></P> <P>A methyl-substituted <I>p</I>-phenylenediamine (PD), <I>N,N,N′,N′</I>-tetramethyl-<I>p</I>-phenylenediamine (TMPD), is examined as a positive redox couple with high energy density for non-aqueous Li-flow batteries. Methyl substitution affects the solubility of the redox couple, as the solubility is increased by a factor of ten, to a maximum solubility of 5.0 <I>M</I> in 1.0 <I>M</I> lithium tetrafluoroborate-propylene carbonate supporting electrolyte due to elimination of the hydrogen bonding between the solute molecules. The methyl substitution also enhances the chemical stability of the cation radical and di-cation being generated from PD, as the redox center is shielded by the methyl groups. Furthermore, this organic redox couple demonstrate two-electron redox reactions at 3.2 and 3.8 V (<I>vs</I>. Li/Li<SUP>+</SUP>); therefore, the volumetric capacity is twice higher compared to conventional one-electron involved redox couples. In a non-flowing Li/TMPD coin-cell, this organic redox couple demonstrates very stable cycleability as a positive redox couple for non-aqueous flow batteries.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TMPD shows promising behaviors as positive redox couple for flow batteries. </LI> <LI> The solubility (5 M) is greatly enhanced by elimination of hydrogen bonding. </LI> <LI> The redox stability is improved by shielding effect from methyl substitution. </LI> <LI> TMPD is electrochemically/chemically stable to give an excellent cycle performance. </LI> </UL> </P>
외과 의사가 시행한 초음파 유도 하 세침흡인 세포 검사의 진단적 유용성
오부희,박영삼,성치원,김철승,Bu Hee Oh,M,D,Young Sam Park,M,D,Chi Won Sung,M,D,and Cheol Seung Kim,M,D,Ph,D 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.3
<B>Purpose:</B> Fine needle aspiration is a safe and relatively accurate procedure for distinguishing benign and malignant lesions. We determined the diagnostic value of ultrasound- guided fine needle aspiration using an extension tube and examination by an endocrine surgeon. <P><B><FONT FACE="Arial Narrow">Methods:</B><FONT FACE="Arial Narrow"> We reviewed the medical records of 257 consecutive patients receiving surgery for thyroid nodules in the Department of Surgery, Jesus Hospital, from January, 2006, to August, 2008. All patients received ultrasound-guided fine needle aspiration with an extension tube. <P><B><FONT FACE="Arial Narrow">Results:</B><FONT FACE="Arial Narrow"> The male to female ratio was 1:<FONT FACE="Arial Narrow">5.5. Definitive histopathological diagnosis revealed benign lesions in 120 cases (47%) and malignant lesions in 137 cases (53%). Benign lesions were composed of nodular goiter (102 cases), follicular adenoma (13 cases), and Hashimoto thyroiditis (5 cases). Malignant lesions were composed of papillary carcinoma (131 cases) and follicular carcinoma (6 cases). Fine needle aspiration cytology revealed benign lesions in 103 cases and malignant lesions in 126 cases. The Overall results of ultrasound-guided FNA were: sensitivity, 94.5%, specificity, 95.0%, positive predictive value, 96.0%, negative predictive value, 93.2%, accuracy rate, 94.7%, false negative, 5.4%, and false positive, 4.9%. Most specimens (96.4%) were amenable for diagnosis. <P><B><FONT FACE="Arial Narrow">Conclusion:</B><FONT FACE="Arial Narrow"> Fine needle aspiration is a good method for the differential diagnosis of thyroid nodules. High resolution ultrasound-guided FNA with an extension tube is helpful for obtaining good specimens. <B><FONT FACE="Arial Narrow">(Ko</B><B></B><B><FONT FACE="Arial Narrow">rean J Endocrine Surg 2008;8:189-193)</B>
장명철,노동영,윤여규,최국진,오승근,Myung Chul Chang,M,D,Dong-Young Noh,M,D,Yeo- Kyu Youn,M,D,Kuk Jin Choe,M,D,and Seung Keun Oh,M,D 대한갑상선-내분비외과학회 2003 The Koreran journal of Endocrine Surgery Vol.3 No.2
Purpose: Primary aldosteronism due to an adrenal cortical adenoma is a surgically curable disease. However, hypertension is known to persist postoperatively in many patients. The aim of this study was to determine the factors influencing the long-term outcome of blood pressure after an adrenalectomy for a primary aldosteronism and to evaluate the changing pattern of renin and aldosterone. Methods: Forty-two cases of primary aldosteronism, which were operated on and followed up at the Department of Surgery, Seoul National University Hospital from January 1986 to June 2001 were included in this study. The subjects were classified into a normotensive group and a hypertensive group and the two groups were compared according to the clinical, biochemical and pathological parameters. Results: After surgery, the aldosterone concentration was decreased and the plasma renin activity was increased. During a mean follow-up period of 28 months, 31 patients (73.8%) had a normal blood pressure without an antihypertensive treatment. The significant risk factors for persistent hypertension were a family history of hypertension, a long duration of preoperative hypertension, a poor response of preoperative spironolactone. The hypertensive group had a higher level of postoperative plasma renin activity and an aldosterone concentration in the long-term follow-up period after surgery. Conclusion: A family history of hypertension, the duration of hypertension and the response to spironolactone were factors influencing persistent hypertension after surgery for a primary aldosteronism. A high level of plasma renin activity and aldosterone during the follow-up period is related to the persistent hypertension. Therefore, early detection and surgery for a primary aldosteronism would reduce the preoperative cardiovascular changes and improve the postoperative outcome. (Korean J Endocrine Surg 2003;3:141-146)
이한별,이규언,장진영,김선회,윤여규,이건욱,오승근,Han-Byoel Lee,M.D.,Kyu Eun Lee,M.D.,Jin-Young Jang,M.D.,Sun-Whe Kim,M.D.,Yeo-Kyu Youn,M.D.,Kuhn Uk Lee,M.D. and Seung Keun Oh,M.D. 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.2
Purpose: Insulinoma is a rare disease for which early diagnosis followed by proper surgical management provides a chance for cure. Analyses of clinicopathological features of patients can help optimize the surgical approach in the treatment of insulinoma. Methods: The records of 13 patients (seven male, six female mean age 44.3 years; age range 17∼62 years) who were diagnosed clinically and pathologically with insulinoma and who underwent surgery between March 1997 and April 2007 at the Department of Surgery, Seoul National University Hospital. Hospital in English please were retrospectively examined. Results: All patients had findings compatible with Whipple's triad. Mean fasting blood sugar was 40.5 mg/dl, serum insulin level was 33.5ՌU/ml, and insulin-to-glucose ratio was 0.6. A prolonged starvation test was performed on six patients. Tumors were localized in 10 patients with a computed tomography (CT) scan and in three patients with CT angiography. Five tumors were located in the pancreas head and uncinate process, five in the body, and four at the body-tail border and tail. Patients underwent resection of tumorby enucleation, distal pancreatectomy, pylorus-preserving pancreaticoduodenectomy, laparoscopic distal pancreatectomy, and duodenum-preserving resection of pancreas head. Four immediate postoperative complications (fluid collection, pancreatic fistula, delayed gastric emptying) occurred. No symptoms or recurrences were apparent during the median 15 month follow-up. Conclusion: Insulinoma is difficult to diagnose correctly without a prolonged duration of symptoms. Localization of insulinoma can be aided by a CT scan and/or CT angiography. Less aggressive operative procedures such as simple enucleation might be a sufficient and feasible procedure for curative resection of benign insulinomas. (Korean J Endocrine Surg 2010;10:99-105)
Oh, Young-Wan,Chris Baek, Seung-heon,Kim, Y. M.,Lee, Hae Yeon,Lee, Kyeong-Dong,Yang, Chang-Geun,Park, Eun-Sang,Lee, Ki-Seung,Kim, Kyoung-Whan,Go, Gyungchoon,Jeong, Jong-Ryul,Min, Byoung-Chul,Lee, Hyun Nature Publishing Group 2016 Nature nanotechnology Vol.11 No.10
<P>Spin-orbit torques arising from the spin-orbit coupling of non-magnetic heavy metals allow electrical switching of perpendicular magnetization. However, the switching is not purely electrical in laterally homogeneous structures. An extra in-plane magnetic field is indeed required to achieve deterministic switching, and this is detrimental for device applications. On the other hand, if antiferromagnets can generate spin-orbit torques, they may enable all-electrical deterministic switching because the desired magnetic field may be replaced by their exchange bias. Here we report sizeable spin-orbit torques in IrMn/CoFeB/MgO structures. The antiferromagnetic IrMn layer also supplies an in-plane exchange bias field, which enables all-electrical deterministic switching of perpendicular magnetization without any assistance from an external magnetic field. Together with sizeable spin-orbit torques, these features make antiferromagnets a promising candidate for future spintronic devices. We also show that the signs of the spin-orbit torques in various IrMn-based structures cannot be explained by existing theories and thus significant theoretical progress is required.</P>