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O'Connell, Robert J.,Excler, Jean-Louis,Polonis, Victoria R.,Ratto-Kim, Silvia,Cox, Josephine,Jagodzinski, Linda L.,Liu, Michelle,Wieczorek, Lindsay,McNeil, John G.,El-Habib, Raphaelle,Michael, Nelson Oxford University Press 2016 The Journal of Infectious Diseases Vol.213 No.12
<P>Background. Prime-boost regimens comprising ALVAC-HIV (prime) and human immunodeficiency virus type 1 (HIV) Env (boost) induce HIV-specific neutralizing antibody and cell-mediated immune responses, but the impact of boost schedule and adjuvant requires further definition. Methods. A phase 1 trial was conducted. In part A (open label), 19 volunteers received oligomeric glycoprotein 160 from HIV strains MN and LAI-2 (ogp160 MN/LAI-2) with dose escalation (25, 50, 100 mu g) and either polyphosphazene (pP) or alum adjuvant. In part B, 72 volunteers received either placebo (n=12) or recombinant canarypox virus expressing HIV antigens (ALVAC-HIV [vCP205]) with different doses and schedules of ogp160 MN/LAI-2 in pP or alum (n = 60). Results. The vaccines were safe and well tolerated, with no vaccine-related serious adverse events. Anti-gp70 V1V2 antibody responses were detected in 17 of 19 part A volunteers (89%) and 10%-100% of part B volunteers. Use of a peripheral blood mononuclear cell-based assay revealed that US-1 primary isolate neutralization was induced in 2 of 19 recipients of ogp160 protein alone (10.5%) and 5 of 49 prime-boost volunteers (10.2%). Among ogp160 recipients, those who received pP were more likely than those who received alum to have serum that neutralized tier 2 viruses (12% vs 0%; P = .015). Conclusions. Administration of ogp160 with pP induces primary isolate tier 2 neutralizing antibody responses in a small percentage of volunteers, demonstrating proof of concept and underscoring the importance of further optimization of prime-boost strategies for HIV infection prevention.</P>
The influence of CEO equity incentives on licensing
O'Connell, Vincent,Lee, Jong-Ho,O'Sullivan, Don Elsevier 2018 European Management Journal Vol.36 No.2
<P><B>Abstract</B></P> <P>In a study of life science firms, we find that, in accordance with predictions drawn from agency theory and behavioral agency theory, CEO stock ownership is negatively associated with licensing while CEO stock options are positively associated with licensing. Furthermore, by combining theoretical insights from the capabilities literature with both agency theory and behavioral agency theory, we predict that a key measure of capabilities in the licensing context—a firm's alliance experience—significantly influences the ways in which CEO equity incentives impact licensing. More specifically, we find that, in accordance with our theoretical predictions, alliance experience positively (negatively) moderates the relationship between CEO stock ownership (CEO stock options) and licensing. Our study contributes to the wider literature on the determinants of licensing by examining whether licensing is sensitive to CEO equity incentives. We also extend the capabilities literature on licensing by examining the contrasting influences of a firm's alliance experience on the relationship between CEO equity incentives and licensing. Our findings also inform behavioral agency-based research on the effects of equity incentives by highlighting the usefulness of a capabilities perspective in augmenting our understanding of the behavioral role of CEO equity incentives.</P>
History and Perspective of Asian Federation on Mental Retardation
Brendan O'Connell 대구대학교 2002 Journal of Asia-Pacific Special Education Vol.2 No.2
It was 29 years ago that AFMR was born in the Philippines. AFMR, however, is still a weak organization. There is little continuity from one president to another. It was only in the 15th Conference in Manila that the subject of "Inclusion: From Vision to Reality, Policy and Action" . It is my belief that there is a new watershed taking place. Instead of making school placements available ro all children, as has been the effeorts in more recent years, we have to change our "backward" special education policies where segregation is the only answer to a world where each child is valued for what they and only can give to everyone else's quality of life.
Hur, J.,O'Connell, J.P.,Bae, K.K.,Kang, K.S.,Kang, J.W. Pergamon Press ; Elsevier Science Ltd 2011 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.36 No.14
The Sulfur-Iodine thermochemical cycle (SI) for water decomposition is a promising candidate for generating hydrogen (H<SUB>2</SUB>) from nuclear energy. An important challenge to the SI process is decomposition of hydrogen iodide (HI) into H<SUB>2</SUB> and iodine (I<SUB>2</SUB>). KIER (Korea Institute of Energy Research) is developing a membrane-based electrolysis cell for this decomposition. The conversion is enhanced if excess iodine is removed before the electrolysis. Since the melting temperature of I<SUB>2</SUB> is high, precipitation is a possible process. Determining the feasibility of this requires solid-liquid equilibrium. While binary solubilities are available for I<SUB>2</SUB> with HI and H<SUB>2</SUB>O, very few ternary data have been reported. In this study, solid-liquid equilibrium data for the ternary (so-called HIx) mixtures were obtained at temperatures from 303 to 359 K at ambient pressure with the concentrations of HI and I<SUB>2</SUB> iodine via titration. The data have been correlated by the phase and reaction equilibrium model developed at the University of Virginia (UVa model) with a small modification that does not change the model's successful description of VLE and VLLE for reactive distillation.
Hot Populations in M87 Globular Clusters
Sohn, Sangmo T.,O'Connell, Robert W.,Kundu, Arunav,Landsman, Wayne B.,Burstein, David,Bohlin, Ralph C.,Frogel, Jay A.,Rose, James A. American Institute of Physics 2006 The Astronomical journal Vol.131 No.2
<P>To explore the production of UV-bright stars in old, metal-rich populations like those in elliptical galaxies, we have obtained Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph far- and near-UV photometry of globular clusters (GCs) in four fields in the giant elliptical (gE) galaxy M87. To a limit of m<SUB>FUV</SUB> ~ 25 we detect a total of 66 GCs in common with the deep HST optical-band study of Kundu et al. Despite strong overlap in V- and I-band properties, the M87 GCs have UV-optical properties that are distinct from clusters in the Milky Way and in M31. M87 clusters, especially metal-poor ones, produce larger hot horizontal-branch populations than do Milky Way analogs. In color plots including the near-UV band, the M87 clusters appear to represent an extension of the Milky Way sequence. Cluster mass is probably not a factor in these distinctions. The most metal-rich M87 GCs in our sample are near solar metallicity and overlap the local E galaxy sample in estimated Mg<SUB>2</SUB> line indices. Nonetheless, the clusters produce much more UV light at a given Mg<SUB>2</SUB>, being up to 1 mag bluer than any gE galaxy in (FUV - V) color. The M87 GCs do not appear to represent a transition between Milky Way-type clusters and E galaxies. The differences are in the correct sense if the clusters are significantly older than the E galaxies.</P><P>Comparisons with Galactic open clusters indicate that the hot stars lie on the extreme horizontal branch, rather than being blue stragglers, and that the extreme horizontal branch becomes well populated for ages ≳5 Gyr. Existing model grids for clusters do not match the observations well, due to poorly understood giant branch mass loss or perhaps high helium abundances. We find that 41 of our UV detections have no optical-band counterparts. Most appear to be UV-bright background galaxies seen through M87. Eleven near-UV variable sources detected at only one epoch in the central field are probably classical novae. Two recurrent variable sources have no obvious explanation but could be related to activity in the relativistic jet.</P>