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RISS 인기검색어
- 검색키워드
- 저자 : Nwaechefu, Olajumoke O. (검색결과 2 건)
- 무료
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Induction of oxidative stress in Clarias gariepinus from Eleyele River in Nigeria
Arojojoye, Oluwatosin A.,Nwaechefu, Olajumoke O.,Ajiboye, John A.,Akintunde, Jacob K. Techno-Press 2016 Advances in environmental research Vol.5 No.3
This study evaluated some markers of oxidative stress in the organs of African Catfish, Clarias gariepinus from Eleyele River in Oyo State, Nigeria. Clarias gariepinus (250 g-400 g) were collected from Eleyele River (a suspected polluted River) and Clarias gariepinus from a clean fish farm (Durantee fisheries) were used as the control. Levels of Malondialdehyde (index of lipid peroxidation), Glutathione (GSH) and activities of antioxidant enzymes- Superoxide dismutase (SOD), Catalase and Glutathione-S-Transferase (GST) were evaluated in the liver, kidney and gills of the fish. From the results, there were significant (p<0.001) increases in malondialdehyde and GSH levels in the liver, kidney and gills of Clarias gariepinus from Eleyele River compared with control. The activity of GST increased significantly (p<0.05; p<0.001) in the liver and kidney of fish from Eleyele River compared with control. There was a significant decrease (p<0.05; p<0.001) in SOD activity in all the organs of Clarias gariepinus from Eleyele River compared with conrol and also a significant (p<0.001) decrease in catalase activity in the gills and kidney of the fish but catalase activity increased in the liver. Increase in lipid peroxidation and alterations in antioxidant status in Clarias gariepinus from Eleyele River show that the fish were under oxidative stress. These suggest that the River is polluted probably as a result of various wastes frequently discharged into the River. This could pose serious health risks to consumers of water and aquatic organisms from the River.
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Evaluation of genotoxic and oxidative stress potential of Ajakanga Landfill Leachate in rats
Oluwatosin A. Arojojoye,Olajumoke O. Nwaechefu,Samuel C. Nkwadinamor 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.1
Genotoxicity and oxidative stress potential of Ajakanga Landfill Leachate (ALL) were investigated in this study. Forty-two male albino rats of the Wistar strain (100 g and 150 g) were divided equally into six groups. Group A (control) animals were given distilled water as drinking water for forty-five days; while groups B-F animals were exposed to 12.5%, 25%, 50%, 75% and 100% leachate respectively via drinking water for forty-five days. The effect of the leachate was assessed on markers of oxidative stress in the liver, kidney and testes of rats; markers of liver function (Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined in the serum and the genotoxic effect of the leachate was investigated using micronucleus assay. Physicochemical and heavy metal analysis were also carried out on the leachate sample. Exposure to ALL resulted in increase in the activities of ALT and AST. A significant increase in malondialdehyde level as well as alterations in antioxidant status was observed in the liver, kidney and testes of the rats compared with control. There was also significant increase in micronuclei formation in the bone marrow of rats exposed to the leachate. Physicochemical and heavy metal analysis of the leachate revealed the presence of some heavy metals at high concentrations as well as other toxic constituents and the total number of active bacteria in the leachate sample were also high. In conclusion, ALL induced oxidative stress and genotoxicity in rats. This suggests that the leachate may be toxic to humans if exposure occurs.
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