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Statistical Process Analysis of Medical Incidents
Suzuki, Norio,Kirihara, Sojiro,Ootaki, Atsushi,Kitajima, Masanori,Nakamura, Shinobu 한국품질경영학회 2001 The Asian Journal on Quality Vol.2 No.2
Personnel engaged in the medical field have implemented continual improvement by team activities in an effort to construct a system that reduces the risks involved in medical care. Knowledge in total quality management (TQM), especially statistical quality control (SQC) developed for industry, seems to be applicable to medical care. This paper describes the application of SQC to continual improvement in medical care.
사방오리 잎의 Triterpenoid 및 Flavonoid 화합물
유영법,Norio Nakamura,Hirotsugu Miyashiro,Masao Hattori,박종철 한국생약학회 2007 생약학회지 Vol.38 No.1
Abstract − In this study, three triterpenoids, two steroids and nine flavonoids were isolated from the leaves of Alnus firma Sieb. et Zucc. On the basis of spectroscopic evidences, the structures of these compounds were established as β-amyrin acetate, β- amyrin, β-sitosterol, alnustic acid methyl ester, β-sitosterol glucoside, pinocembrin, alnustinol, quercetin, quercetin-3-O-α-Larabinofuranoside, quercetin-3-O-α-L-rhamnopyranoside, quercetin-3-O-β-D-glucopyranoside, myricetin-3-O-β-D-galactopyranoside, (+)-catechin and (−)-epicatechin.
Effects of Triterpenoids and Flavonoids Isolated from Alnus firma on HIV-1 Viral Enzymes
유영법,Hirotsugu Miyashiro,Norio Nakamura,Masao Hattori,박종철 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Triterpenoids and flavonoids isolated from Alnus firma S. Z. were found to inhibit HIV-1 virus replication and controlled its essential enzymes. In this study, the inhibition of HIV-1 viral replication and its essential enzymes, such as reverse transcriptase, protease and α-glucosidase, were observed using 18 Korean plant extracts. Among the extracts, the methanol extract of Alnus firma leaves showed potent inhibition against the HIV-1 induced cytopathic effect (CPE) in MT-4 cells on microscopic observation (the minimum concentration for complete inhibition of HIV-1 induced CPE, IC=50 µg/mL). Thus, 14 compounds were isolated and identified from the methanol extract of Alnus firma leaves. Of these compounds, the alnustic acid methyl ester exhibited inhibition against HIV-1 protease, with an IC50 of 15.8 µM, and quercetin, quercitrin and myricetin 3-O-β-D-galactopyranoside displayed inhibition against HIV-1 reverse transcriptase, all with IC50 values of 60 µM. Based on these results, the viral replication inhibition of the methanol extract of Alnus firma leaves was adjudged to be acutely related to the protease inhibition activation of the alnustic acid methyl ester as well as the reverse transcriptase inhibition activation of flavonoids.
MIN, Byung-Sun,NAKAMURA, Norio,MIYASHIRO, Hirotsugu,BAE, Ki-Whan,HATTORI, Masao 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid β, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3β,7β-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid β, (24S)-lanosta-7,9(11)-diene-3β.24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC_50 values of 20-90 μM.
Effects of Triterpenoids and Flavonoids Isolated from Alnus firma on HIV-1 Viral Enzymes
Yu, Young-Beob,Miyashiro, Hirotsugu,Nakamura, Norio,Hattori, Masao,Park, Jong-Cheol 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Triterpenoids and flavonoids isolated from Alnus firma S. Z. were found to inhibit HIV-1 virus replication and controlled its essential enzymes. In this study, the inhibition of HIV-1 viral replication and its essential enzymes, such as reverse transcriptase, protease and ${\alpha}-glucosidase$, were observed using 18 Korean plant extracts. Among the extracts, the methanol extract of Alnus firma leaves showed potent inhibition against the HIV-1 induced cytopathic effect (CPE) in MT-4 cells on microscopic observation (the minimum concentration for complete inhibition of HIV-1 induced CPE, IC=50 ${\mu}g/mL$). Thus, 14 compounds were isolated and identified from the methanol extract of Alnus firma leaves. Of these compounds, the alnustic acid methyl ester exhibited inhibition against HIV-1 pretense, with an $IC_{50}$ of 15.8 ${\mu}M$, and quercetin, quercitrin and myricetin $3-O-{\beta}-D-galactopyranoside$ displayed inhibition against H IV-1 reverse transcriptase, all with $IC_{50}$ values of 60 ${\mu}M$. Based on these results, the viral replication inhibition of the methanol extract of Alnus firma leaves was adjudged to be acutely related to the protease inhibition activation of the alnustic acid methyl ester as well as the reverse transcriptase inhibition activation of flavonoids.
Inhibitory Effect of Triterpenes from Crataegus pinatifida on HIV-I Protease
Min, Byung Sun,Jung, Hyun Ju,Lee, Jun Sung,Kim, Young Ho,Bok, Song Hae,Ma, Chao Mei,Nakamura, Norio,Hattori, Masao,Bae, KiHwan 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100㎍/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol(1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV-1 protease with IC_50 values of 5.5 and 8.0μM, respectively.
Anti-Human Immunodeficiency Virus-Type 1 Activity of Constituents from Juglans mandshurica
Min, Byung-Sun,Lee, Hyeong-Kyu,Lee, Sang-Myung,Kim, Young-Ho,Bae, Ki-Hwan,Otake, Toru,Nakamura, Norio,Hattori, Masao The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.4
Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark of Juglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration ($IC_{100}$) value of $25{\;}{\mu\textrm{g}}/ml$ and maximum cytotoxic concentration ($CC_{100}$) value of above $100{\;}{\mu\textrm{g}}/ml$. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.