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Norberg, Erik,Lako, Ana,Chen, Pei-Hsuan,Stanley, Illana A,Zhou, Feng,Ficarro, Scott B,Chapuy, Bjoern,Chen, Linfeng,Rodig, Scott,Shin, Donghyuk,Choi, Dong Wook,Lee, Sangho,Shipp, Margaret A,Marto, Jarr Macmillan Publishers Limited, part of Springer Nat 2017 CELL DEATH AND DIFFERENTIATION Vol.24 No.2
<P>Diffuse large B-cell lymphomas (DLBCLs) are a highly heterogeneous group of tumors in which subsets share molecular features revealed by gene expression profiles and metabolic fingerprints. While B-cell receptor (BCR)-dependent DLBCLs are glycolytic, OxPhos-DLBCLs rely on mitochondrial energy transduction and nutrient utilization pathways that provide pro-survival benefits independent of BCR signaling. Integral to these metabolic distinctions is elevated mitochondrial electron transport chain (ETC) activity in OxPhos-DLBCLs compared with BCR-DLBCLs, which is linked to greater protein abundance of ETC components. To gain insights into molecular determinants of the selective increase in ETC activity and dependence on mitochondrial energy metabolism in OxPhos-DLBCLs, we examined the mitochondrial translation pathway in charge of the synthesis of mitochondrial DNA encoded ETC subunits. Quantitative mass spectrometry identified increased expression of mitochondrial translation factors in OxPhos-DLBCL as compared with the BCR subtype. Biochemical and functional assays indicate that the mitochondrial translation pathway is required for increased ETC activity and mitochondrial energy reserves in OxPhos-DLBCL. Importantly, molecular depletion of several mitochondrial translation proteins using RNA interference or pharmacological perturbation of the mitochondrial translation pathway with the FDA-approved inhibitor tigecycline (Tigecyl) is selectively toxic to OxPhos-DLBCL cell lines and primary tumors. These findings provide additional molecular insights into the metabolic characteristics of OxPhos-DLBCLs, and mark the mitochondrial translation pathway as a potential therapeutic target in these tumors.</P>
Groupdynamics -How to strengthen the success of projects?
( Monica Norberg(msc Pedagogy) ),( Mia Ljungblom(msc Pedagogy) ) 한국품질경영학회 2015 한국품질경영학회 학술대회 Vol.2015 No.2
Background To improve the efficiency, to reduce costs, but still maintain or even increase the quality is a necessity for organizations today. To meet the demands and needs organizations implement various improvement models which often are carried out in different projects. Research shows that 60% of projects fail due to a lack of cooperation within the project team. How a group works together affects effectiveness and performance of the work. Research also shows that effectiveness of a group is achieved only if the group reaches a certain stage of the group dynamic process. Various group dynamic processes describe how a team develops over time where Wheelan’s model focuses on relationships/tasks, but also efficiency, structures, and goals. SPGR, a group dynamic theory by Sjøvold lifts, in addition to group dynamics the individual perspective; how individuals are included in a group. If a group should be functional and effective; is it enough to be aware of the group process and to use a measuring tool to see how the group develops? Purpose The purpose with the study is to explore, during a three-year-period, if it is possible to follow a group’s development with the support of measurement tools, and based on the measurement actively work with group development. Methodology The study is longitudinal and will continue for three years, but in this first report, the first year’s results will be presented. In September 2014, 48 students began a program at a Swedish university. The program is focused on leadership, quality, and improvement. The students are divided in 9 groups with 3-6 people in each group. At three occasions during the academic year; at the beginning of October 2014, in the beginning of December, and in May 2015, each student completed two surveys: GDQ and SPGR. During the year, several observations of the groups implemented as a complement to the survey responses. Findings The result so far has shown how groups evolve differently over time and with the support of the two different measurement tools, it provides a good basis for group development. The groups have come into different phases of a group which has impacted on how they act in the group and effectiveness has been affected. The results also demonstrate that it seems not enough to use one measurement method to achieve a good picture of the group development. Research Limitation/implication Although efforts to maintain each group intact, it has been impossible when students have stopped or changed program. All changes in the groups have been attempted to be made with minimal impact on as few groups as possible. Originality/Value We can right now see the use of only one measurement is not enough to determine a group’s development. The result demonstrates that it is possible to note how different groups develop and how it is visible in the result.
HD 기체에서의 수소 및 중수소 원자핵 스핀 - 격자 완화시간에 관한 핵자기공명 연구
유종훈(Jonghun Lyou),R. E. Norberg(R. E. Norberg) 한국자기학회 1994 韓國磁氣學會誌 Vol.4 No.1
The proton and deuteron spin-lattice relaxation times, T₁(H) and T₁(D), have been measured in HD between 30 K and 313 K in the pressure of 0.67 - 1.92 atm. The nuclear magnetic resonance frequencies are respectively 358.012 ㎒ for a proton and 58.958 ㎒ for a deuteron. From the measurements of T₁(H) and T₁(D) the ratio of the correlation times τ₁ and τ₂ that are associated with the molecular angular momentum operators was obtained. The nuclear spin-lattice relaxation time at J = 1 state has been observed to have a temperature dependence being proportional to T^(0.25).