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The strategies for scientific literacy in Indonesia
Prakoso Bhairawa Putera,Sinta Ningrum,Suryanto Suryanto,이다 위디아닝시,Yan Rianto 아시아기술혁신학회 2022 Asian Journal of Innovation and Policy Vol.11 No.2
The historical aspects, policies, institutions, awards and measurement results of scientific literacy and scientific culture development in Indonesia have currently attracted further exploration. This paper utilizes secondary data research, further analyzed by employing the Supplementary Analysis technique. The results revealed that the tradition of writing and publishing scientific journals in Indonesia has existed ever since the Dutch East Indies with the journal's publication entitled 'Natuurkundig tijdschrift voor Nederlandsch Indië' in 1850. To date, Indonesia has owned 5,990 nationally accredited journals. Policy support has been provided at the national and regional levels, despite limitations in cultivating literacy and reading habit. From the institutional perspective, Indonesia provides a wide array of public support, including the effort of the Ministry of Education and Culture for advocating the national literacy movement and the availability of a reference database and scientific access established by the National Library; the Indonesian Institute of Sciences, and the Ministry of Research and Technology. Similarly, in the award-related perspective, the Indonesia government has granted awards to individuals or groups and local governments engaging in the cultivation of scientific literacy and scientific culture. However, among the global measurements for literacy development in Indonesia (in 2020) recorded that three indicators scored less than those in 2019.
The Dynamics of Research Output by Indonesian Scientist, Period of 1945-2021
Prakoso Bhairawa Putera,이다 위디아닝시,Sinta Ningrum,Suryanto Suryanto,Yan Rianto 아시아기술혁신학회 2022 Asian Journal of Innovation and Policy Vol.11 No.3
This research was conducted by applying a bibliometric analysis to determine the dynamics of research topics from ten percent of research output (international publications) generated by Indonesian scientists from the period of 1945-2021. This study utilizes VOSviewers version 1.6.18 for analysis and visualization of bibliometric networks. The research results indicate that 50.24% of Indonesian international publications are published in the form of articles, with subjects such as: Agricultural and Biological Sciences, Medicine, and Earth and Planetary Sciences as the most dominating subject areas. Regarding the author, Tjia, MO from Bandung Institute of Technology was acknowledged as the top author in terms of the number of publications produced for two periods. The article entitled "Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013" (Ng et al., 2014) became the most cited one.
Five clusters of flood management articles in Scopus from 2000 to 2019 using social network analysis
Rosy Riani Kusuma,Ida Widianingsih,Sinta Ningrum,Rita Myrna 한국과학학술지편집인협의회 2021 Science Editing Vol.8 No.1
Purpose This study aimed to analyze the bibliographic characteristics and content of articles on flood management published in journals indexed by Scopus written by researchers from throughout the world from 2000 to 2019. Methods We obtained data from the Scopus database on October 2, 2020. “Flood management” was used to search across several categories, including article title, abstract, and keywords, filtered by subject area (social science; environmental science; and business, management, and accounting). We only retrieved articles written in English. We conducted content analysis using the VOSviewer software and visualized the co-occurrence of keywords and bibliographic coupling of sources and countries. Results Following the study protocol, we found 984 articles on flood management over the past 20 years. Among the three subject areas, environmental science was the most productive field for publishing flood management articles. Flood control, flood management, and risk assessment were the top three most popular topics. Flood management publications were published in 266 journals. In total, 86 countries collaborated to produce research related to flood management. Natural Hazard Journal and Journal of Flood Risk Management were the most prominent journals. Institutions from Europe ominated the top 10 institutions with the most publications by affiliated researchers. Conclusion From a global perspective, flood management research in the past two decades has increased significantly. There were five major topic clusters, and European-published journals ominated publications. Thus, Asian institutions need to conduct more active research on this topic.
Mustopa, Apon Zaenal,Wijaya, Sri Kartika,Ningrum, Ratih Asmana,Agustiyanti, Dian Fitria,Triratna, Lita,Alfisyahrin, Wida Nurul The Korean Society for Microbiology and Biotechnol 2019 한국미생물·생명공학회지 Vol.47 No.3
Hepatitis B treatments using immune therapy are gaining interest because of the improvements in dendritic cell performance for antigen presentation, which induces an appropriate immune response and raises patient survival rates. This research aims to produce a significant amount of the HBcAg antigen, which can induce an immune response and have a curative effect on HBV infection. In this study, the HBV subgenotype B3 of the HBcAg gene was used, which is dominant in Indonesia. Further, Lactococcus lactis bacteria was used as the host because of its safety and tightly regulated protein expression. The codon usage for the HBcAg gene was optimized to improve protein expression in L. lactis, which is important because a codon is not random between species. The HBcAg gene is attached to a pNZ8148 plasmid and transformed into the L. lactis NZ3900 expression host. The results confirm that a positive protein band (21 kDa) in two fractions of purified HBcAg was recognized by both western blotting and dot blot hybridization, even if the HBcAg optimized codon has higher GC contents than that suggested for L. lactis expression. Overall, this research strengthens the broad use of L. lactis bacteria for any protein expression, including higher protein expression of codon optimized HBcAg gene compared to non-optimized genes. Furthermore, the improvement in the codon optimization of the HBcAg gene significantly increases the total protein expression by 10-20%, and the expression level of the codon optimized HBcAg increases 1.5 to 3.2-times that of the native HBcAg.
Prakoso Bhairawa Putera,Suryanto Suryanto,Sinta Ningrum,Ida Widianingsih 한국과학학술지편집인협의회 2020 Science Editing Vol.7 No.2
Purpose: The aim of this study was to analyze the bibliometric characteristics of articles on innovation systems published in Scopus-indexed journals by authors with Indonesian affiliations from 1998 to 2019, in comparison with those published by authors from Singapore and Malaysia. Methods: We conducted a bibliometric and content analysis of publications in the Scopus database. A total of 138 articles from Indonesia, 209 articles from Singapore, and 309 articles from Malaysia were analyzed. They were classified by publication year, authors, co-authors’ country, affiliation, keywords, and journal title. Results: Authors with affiliations from Malaysia were more productive than authors from Singapore and Indonesia during 1998 to 2019. In terms of the quality of papers, Singapore had more productive authors than Malaysia and Indonesia based on the citation frequency. Conclusion: Although fewer articles on innovation systems were published by authors from Indonesia than by those from Malaysia and Singapore, the recent increase in the number of publications by Indonesian authors suggests that number of articles from Indonesia will soon surpass those from the other two countries. International collaboration will help accelerate the number of publications.
( Apon Zaenal Mustopa ),( Sri Kartika Wijaya ),( Ratih Asmana Ningrum ),( Dian Fitria Agustiyanti ),( Lita Triratna ),( Wida Nurul Alfisyahrin ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 한국미생물·생명공학회지 Vol.47 No.3
Hepatitis B treatments using immune therapy are gaining interest because of the improvements in dendritic cell performance for antigen presentation, which induces an appropriate immune response and raises patient survival rates. This research aims to produce a significant amount of the HBcAg antigen, which can induce an immune response and have a curative effect on HBV infection. In this study, the HBV subgenotype B3 of the HBcAg gene was used, which is dominant in Indonesia. Further, Lactococcus lactis bacteria was used as the host because of its safety and tightly regulated protein expression. The codon usage for the HBcAg gene was optimized to improve protein expression in L. lactis, which is important because a codon is not random between species. The HBcAg gene is attached to a pNZ8148 plasmid and transformed into the L. lactis NZ3900 expression host. The results confirm that a positive protein band (21 kDa) in two fractions of purified HBcAg was recognized by both western blotting and dot blot hybridization, even if the HBcAg optimized codon has higher GC contents than that suggested for L. lactis expression. Overall, this research strengthens the broad use of L. lactis bacteria for any protein expression, including higher protein expression of codon optimized HBcAg gene compared to non-optimized genes. Furthermore, the improvement in the codon optimization of the HBcAg gene significantly increases the total protein expression by 10-20%, and the expression level of the codon optimized HBcAg increases 1.5 to 3.2-times that of the native HBcAg.
( Lita Meilina ),( Sri Budiarti ),( Apon Zaenal Mustopa ),( Huda Shalahudin Darusman ),( Lita Triratna ),( Muhammad Ajietuta Nugraha ),( Muhammad Sabiq Bilhaq ),( Ratih Asmana Ningrum ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 한국미생물·생명공학회지 Vol.49 No.1
Type I Interferons (IFNα) are known for their role as biological anticancer agents owing to their cell-apoptosis inducing properties. Development of an appropriate, cost-effective host expression system is crucial for meeting the increasing demand for proteins. Therefore, this study aims to develop codon-optimized IFNα-2b in L. lactis NZ3900. These cells express extracellular protein using the NICE system and Usp<sub>45</sub> signal peptide. To validate the mature form of the expressed protein, the recombinant IFNα-2b was screened in a human colorectal cancer cell line using the cytotoxicity assay. The IFNα-2b was successfully cloned into the pNZ8148 vector, thereby generating recombinant L. lactis pNZ8148-SPU<sub>sp45</sub>-IFNα-2b. The computational analysis of codon-optimized IFNα-2b revealed no mutation and amino acid changes; additionally, the codon-optimized IFNα-2b showed 100% similarity with native human IFNα-2b, in the BLAST analysis. The partial size exclusion chromatography (SEC) of extracellular protein yielded a 19 kDa protein, which was further confirmed by its positive binding to anti-IFNα-2b in the western blot analysis. The crude protein and SEC-purified partial fraction showed IC<sub>50</sub> values of 33.22 μg/ml and 127.2 μg/ml, respectively, which indicated better activity than the metabolites of L. lactis NZ3900 (231.8 μg/ml). These values were also comparable with those of the regular anticancer drug tamoxifen (105.5 μg/ml). These results demonstrated L. lactis as a promising host system that functions by utilizing the pNZ8148 NICE system. Meanwhile, codon-optimized usage of the inserted gene increased the optimal protein expression levels, which could be beneficial for its large-scale production. Taken together, the recombinant L. lactis IFNα-2b is a potential alternative treatment for colorectal cancer. Furthermore, its activity was analyzed in the WiDr cell line, to assess its colorectal anticancer activities in vivo.