Magnetic field-induced improvement in O2/N2 gas separation applications of simultaneously co-casted superparamagnetic mixed matrix membranes

Nahid Nikpour,Amir H. Montazer,Ali Khayatian 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

For industrial purposes and current challenges facing the world, the selective separation of oxygen andnitrogen gases from the air by polymer mixed matrix membranes is crucial. Due to the diamagnetic natureof water molecules used in the fabrication of the polymer membranes, the magnetic field (H) mayaffect the resulting separation performance. Here, using a simultaneous co-casting method, empty andsuperparamagnetic Fe3O4 nanoparticle-filled double-layer polyethersulfone (PES)/Pebax 1657 mixedmatrix membranes are fabricated under different external magnetic field intensities in the range ofH = 0–5000 Oe. The O2 and N2 permeances of the PES/Pebax membranes are found to increase withincreasing the magnetic field intensity, arising from an enhancement in the polymer chain mobility. The Fe3O4 nanoparticles form thick root-like superparamagnetic channels on the double-layer PES/Pebax surface at a magnetic field intensity of 4000 Oe, resulting in an O2/ N2 ideal selectivity of 3.59at a feed gas pressure of 10 bar. This indicates an improvement of 40% in the selectivity compared to asingle-layer Pebax membrane filled with Fe3O4 nanoparticles.

Curcumin-loaded Fe-MOF/PDMS porous scaffold: Fabrication, characterization, and biocompatibility assessment

Soghra Nikpour,Zeinab Ansari-Asl,Tahereh Sedaghat,Elham Hoveizi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-

Fabrication of biocompatible scaffolds that can facilitate the mending of damaged tissue has attractedmuch attention. In this study, the preparation and structural investigation of a curcumin-loaded Fe(II)metal–organic framework/polydimethylsiloxane sponge, Cur/Fe-MOF/PDMS, are reported. Various techniquessuch as FTIR (Fourier-transform infrared), XRD (X-ray diffraction), SEM (scanning electron microscope),TEM (transmission electron microscope), EDS (energy-dispersive X-ray spectroscopy) mapping,and XPS (X-ray photoelectron spectroscopy) have been used to investigate the as-fabricated materials. Results confirm the successful incorporation of curcumin and Fe-MOF into the PDMS matrix. Theobtained SEM images indicate the sponge-like structures of the PDMS and the Fe-MOF/PDMS composite. Indeed, the results from in vivo show animals all to be survived without any unusual responses to thetransplant. According to macroscopic observation, the Fe-MOF/PDMS and Cur/Fe-MOF/PDMS scaffoldsseem better confederates than the pure PDMS. H&E staining has confirmed enhanced healing and revascularizationin the Cur/Fe-MOF/PDMS than the PDMS and Fe-MOF/PDMS scaffolds. Additionally, a twostageprofile was observed for the release of curcumin into PBS (phosphate-buffered saline) solution. The hydrophilic property of the Fe-MOF resulted in fast release at the first stage. These results exhibit thatthe Cur/Fe-MOF/PDMS sponge can serve as a 3D porous substrate in the tissue engineering (TE) field.

Synthesis of new phosphate derivative of benzothiazole and its inhibiting effect on two series of human neuroblastoma cell growth

Mahshid Nikpour Nezhati,Gholam Hossein Riazi,Homayon Ahmad Panahi,Elham Moniri,Nasir Ahmad Rajabi,Mohammad Mehdi Sadughi,Natasha Rahmani Zaker,Robab Ardekani,Reihaneh Kooshkestani 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.3

The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H3PO3/POCl3. The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC50 value) ranging from 14-23 μM (corresponding to human neuroblastoma SK-BE (2)and SK-NM-C cells).

Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients

Farahani, Najmeh,Nikpour, Parvaneh,Emami, Mohammad Hassan,Hashemzadeh, Morteza,Zeinalian, Mehrdad,Shariatpanahi, Seyed Shervin,Salehi, Rasoul Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20. Materials and Methods: Colorectal patients with a positive history of familial cancers were selected by evaluating medical records. Based on Amsterdam II criteria for Lynch syndrome 20 families were short listed. DNA was extracted from formalin fixed paraffin embedded tumour and adjacent normal tissues resected from the index case in each family. Extracted DNA was subjected to MT1XT20 mononucleotide marker analysis and assessment with a commercially available five marker MSI testing kit (Promega, USA). IHC also was performed on tissue sections and the results were compared with PCR based data. Results: Eight (40%), seven (35%) and five (25%) cases were MSI positive using with the Promega kit, IHC and MT1XT20, respectively. Among the markers included in Promega kit, BAT26 marker showed instability in all 8 samples. NR24 and NR21 markers showed instability in 7 (87.5%), and BAT25 and MONO 27 in 6 (75%) and 5 (62.5%). Conclusions: Although MT1XT20 was earlier reported as a valid standalone marker for MSI testing in CRC patients, we could not verify this in our Iranian patients. Instead BAT26 among the markers included in Promega MSI testing kit showed instability in all 8 MSI-H CRC samples. Therefore, it seems BAT26 could act well as a single marker for MSI testing in Iranian CRC patients.

Poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] brushesgrafted onto siliceous support for preconcentration and determination of cobalt (II) in human plasma and environmental samples

Homayon Ahmad Panahi,Mahshid Nikpour Nezhati,Rohollah Abedini Kashkoieh,Elham Moniri,Igor Yu. Galaev 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.9

A chelating matrix prepared by surface grafting of polymer containing a functional monomer, poly[1-(N,Nbis-carboxymethyl)amino-3-allylglycerol-co-methylacrylamide] (poly(AGE/IDA-co-DMAA) onto a modified silica. The silica surface was modified by silylation with 3-mercaptopropyltrimethoxysilane followed by graft polymerization. Monomer of allyl glycidyl ether-iminodiacetic acid was synthesized by reaction of allyl glycidyl ether with iminodiacetic acid. The chelating sorbent can be reused for 15 cycles of sorption-desorption without any significant change in sorption capacity. The profile of cobalt uptake on the sorbent reflects good accessibility of chelating sites in poly(AGE/IDA-co-DMAA)-grafted silica gel. The equilibrium adsorption data of Co(II) on modified sorbent were analyzed by Langmuir, Freundlich, Temkin and Redlich-Peterson models. The method was applied for cobalt ions determination in human plasma and sea water sample with satisfactory results.

Synthesis, characterization and application of allyl phenol modified amberlite XAD-4 resin for preconcentration and determination of copper in water samples

Homayon Ahmad Panahi,Mahshid Nikpour Nezhati,Elham Moniri,Somayeh Rangbar Kelahrodi,Farah Assadian,Meghdad Karimi 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.4

A new chelating resin was prepared by coupling Amberlite XAD-4 with phenol through an azo spacer,then modified by allyl bromide and characterized (by elemental analysis and IR) and studied for preconcentration of Cu(II) using flame atomic absorption spectrometry (FAAS) for metal monitoring. The optimum pH value for sorption of the above mentioned metal ion was 4.5. The resin was subjected to chemical evaluation through batch binding and column chromatography of Cu(II). The chelating resin can be reused for 15 cycles of sorption-desorption without any significant change in sorption capacity. A recovery of 98% was obtained for the metal ion with 0.5M HNO3 as eluting agent. The equilibrium adsorption data of Cu(II) on modified resin were analyzed by Langmuir, Freundlich and Temkin models. Based on equilibrium adsorption data the Langmuir, Freundlich and Temkin constants were determined to be 0.061, 0.193 and 0.045 at pH 4.5 and 25 oC. The method was applied for the copper determination from industrial waste water sample.

Deregulation of MTDH Gene Expression in Gastric Cancer

Baygi, Modjtaba Emadi,Nikpour, Parvaneh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Aim: Gastric cancer is the third most frequent cause of cancer mortality worldwide. In Iran, it is one of the leading causes at the national level. Localized at chromosome 8q22, the human MTDH gene has been reported to be over-expressed in a spectrum of malignancies. However, since there is a lack of data concerning with expression in gastric cancer at the transcriptional level, in this study we evaluated MTDH expression in Iranian cases. Methods: Totally, thirty paired gastric samples were examined by quantitative real-time RT-PCR. Results: Although the mRNA expression was significantly elevated in 46.6% of the examined tumor tissues; its expression was low in others (36.6%). Moreover, there was only a marginal statistical difference between the MTDH gene expression of all tumor specimens compared to their paired non-tumor ones and no statistically significant association with the grades and types of the tumors. Conclusion: Taken together, our results demonstrated that expression of MTDH at the transcriptional level may be increased in gastric cancer tissue samples but with considerable heterogeneity. Due to this, it may have the potential to be used as a target for diagnostic/therapeutic purposes only in a subset of patients.

Polyamines, Affected the Nitrogen Partitioning, Protein Accumulation and Amino Acid Composition of Mung Bean Under Water Stress

Salar Farhangi-Abriz,Reza Faegi-Analou,Neda Nikpour-Rashidabad 한국작물학회 2017 Journal of crop science and biotechnology Vol.20 No.4

Field experiments were conducted in two growing seasons as a split plot based on a randomized complete block design with four replications. Irrigation intervals (irrigation after 70 and 170 mm evaporation from class A pan) were assigned to main plots and spraying of polyamines (putrescine 0.1 mM, spermidine 0.1 mM, and spermine 0.1 mM) were allocated to the subplots. T nitrogen and sulfur content of different parts of mung bean, nitrogen uptake, protein filling duration, protein percentage of grain, maximum protein content per grains, grain and protein yields per unit area, methionine and serine contents reduced under water limitation, but grain filling rate, isoleucine, leucine, threonine, aspartic acid, glutamic acid, glycine, proline, tyrosine and arginine contents in grains raised. Treatment of plants with polyamines improved the contents of nitrogen and sulfur, nitrogen uptake, protein-filling duration, protein percentage, grain and protein yield per unit area, and histidine, methionine, phenylalanine, threonine, aspartic acid, glutamic acid, tyrosine, and arginine contents in grain. Putrescine had the highest grain and protein yields. Our results clearly indicated that polyamines with improving histidine, methionine, phenylalanine, and threonine content in mung bean grains improved the quality of mung bean protein.

Lack of Evidence of the Role of APOA5 3’UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome

Samaneh Salehi,Modjtaba Emadi-Baygi,Majdaddin Rezaei,Roya Kelishadi,Parvaneh Nikpour 대한당뇨병학회 2018 Diabetes and Metabolism Journal Vol.42 No.1

Background: Metabolic syndrome (MetS) is a complex and multifactorial disorder characterized by insulin resistance, dyslipidaemia, hyperglycemia, abdominal obesity, and elevated blood pressure. The apolipoprotein A5 (APOA5) gene variants have been reported to correlate with two major components of MetS, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglyceride. In the present study, we explored the associations between five single nucleotide polymorphisms (SNPs) of APOA5 gene and the MetS risk. Methods: In a case-control design, 120 Iranian children and adolescents with/without MetS were genotyped by polymerase chain reaction-sequencing for these SNPs. Then, we investigated the association of SNPs, individually or in haplotype constructs, with MetS risk. Results: The rs34089864 variant and H1 haplotype (harboring the two major alleles of rs619054 and rs34089864) were associated with HDL-C levels. However, there was no significant association between different haplotypes/individual SNPs and MetS risk. Conclusion: These results presented no association of APOA5 3’UTR SNPs with MetS. Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group.