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Simulation of Subassembly Production at Shipyards
Hertel, Erik,Nienhuis, Ubald,Steinhauer, Dirk Society for Computational Design and Engineering 2006 International Journal of CAD/CAM Vol.6 No.1
To survive in the current shipbuilding industry it is of vital importance for shipyards to achieve an optimal utilization of resources, make an achievable planning and ensure that this planning is kept. Possible problems should be eliminated before production starts and if unexpected disturbances occur in the actual production the right measures should be taken. Due to the dynamic nature of the production process, the continuous variation in products and the complexity of both, all this can hardly be achieved with conventional static planning and analysis systems. Simulation provides a solution here, since this enables the modelling and evaluation of the dynamic relations between product and production process. After a global introduction to production simulation in general and the application of simulation at the Flensburger shipyard, this paper presents a tool that has been developed to simulate the various complex assembly processes taking place at shipyards. Subsequently the simulation model for the subassembly production at Flensburger, in which this tool is applied, will be discussed.
Kim, Yoo-Jin,Kim, Yoon-Sang,Larochelle, Andre,Renaud, Gabriel,Wolfsberg, Tyra G.,Adler, Rima,Donahue, Robert E.,Hematti, Peiman,Hong, Bum-Kee,Roayaei, Jean,Akagi, Keiko,Riberdy, Janice M.,Nienhuis, Ar American Society of Hematology 2009 Blood Vol.113 No.22
<B>Abstract</B><P>We previously reported that lentiviral vectors derived from the simian immunodeficiency virus (SIV) were efficient at transducing rhesus hematopoietic repopulating cells. To evaluate the persistence of vector-containing and -expressing cells long term, and the safety implications of SIV lentiviral vector-mediated gene transfer, we followed 3 rhesus macaques for more than 4 years after transplantation with transduced CD34+ cells. All 3 animals demonstrated significant vector marking and expression of the GFP transgene in T cells, B cells, and granulocytes, with mean GFP+ levels of 6.7% (range, 3.3%-13.0%), 7.4% (4.2%-13.4%), and 5.6% (3.1%-10.5%), respectively. There was no vector silencing in hematopoietic cells over time. Vector insertion site analysis of granulocytes demonstrated sustained highly polyclonal reconstitution, with no evidence for progression to oligoclonality. A significant number of clones were found to contribute at both 1-year and 3- or 4-year time points. No vector integrations were detected in the MDS1/EVI1 region, in contrast to our previous findings with a γ-retroviral vector. These data show that lentiviral vectors can mediate stable and efficient long-term expression in the progeny of transduced hematopoietic stem cells, with an integration profile that may be safer than that of standard Moloney murine leukemia virus (MLV)-derived retroviral vectors.</P>