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Nicholas Y. Duvernay 고려대학교 언어정보연구소 2018 언어정보 Vol.26 No.-
Duvernay, Nicholas Y. 2018. Learner Aptitude Variables in L2 Learners' Strategy Frame Shift: A Comparative Study on the Effects of Collaborative Group Discussion. Language Information 26. 129-152. This study expands upon the previous research (Duvernay & You, 2017) made to investigate the Collaborative Group Discussion** method and its effects on learning strategy use as described in the Strategy Inventory for Language Learning (SILL, Oxford 1995). In the current study, additional factors in the form of learner types—including personality, gender and learner aptitude—have been included as variables that may affect L2 learners' Strategy Inventory Frame Shift*** after a semester of classroom CGD sessions. The study found that learner types have a significant impact on variations in CGD Strategy Frame Shift (SFS) results and that the three main factors indicate interconnected correlations. In particular, introverted personalities, females and language learners of lower language-learning aptitude all demonstrated SFS in the form of improvements in metacognitive, affective and social strategy use.
Treuheit Nicholas A.,Crawford Nicholas F.,Maki Steven,Payne Jason,Allen Jeff 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.4
Purpose Biosimilars can effectively reduce the cost of healthcare by providing a new source of competition for original drugs. A cornerstone of biosimilar development is assembling a comprehensive package of analytical data that demonstrates physicochemical biosimilarity to justify a shorter regimen of clinical trials. The purpose of the present work was to present part of a biosimilarity data package comparing Pfenex pegfilgrastim to its reference, Amgen’s Neulasta™ and to highlight a deuterium exchange experiment that can be used as part of the analytical tool box to demonstrate biosimilarity. Methods We used circular dichroism (CD), fluorescence, biolayer interferometry (BLI), and hydrogen–deuterium exchange (HDX) mass spectrometry experiments to analyze structural similarity between Pfenex pegfilgrastim and its reference, Amgen’s Neulasta™. In particular, we incorporated a novel HDX experiment comparing binding to the receptor by Pfenex pegfilgrastim or Neulasta™. Results The characterization experiments showed a high degree of similarity between the molecules, from secondary structure (CD/fluorescence), binding (BLI), and deuterium uptake in free and bound forms (HDX). Notably, the receptor-binding experiment found seven peptides that were similarly protected upon binding to both pegfilgrastim molecules. Conclusion These select experiments are a subset of the required characterization to demonstrate similarity, but they represent a progression of structural analysis that is enhanced and strengthened by a novel HDX experiment. This method improves our understanding of this interaction and gives us another analytical tool for demonstrating biosimilarity that should be adaptable for use with other biosimilar products in the future.
Nicholas F. Bugai(니콜라이 부가이) 한국외국어대학교 역사문화연구소 2001 역사문화연구 Vol.14 No.-
Развитие национальных процесов в стране в первой половине 20 -х годов и, особенно, после образования Союза ССР(l922 г.), связанных с приятием государством в качестве новой народнохозайственной политики-НЭПа(новая экономическая политика), началом реализации новых планов несомиенно способствовали политическому обновлению общества в целом. В этот период наблюдается и этническая мобилизация. Представители разных национальностей все активнее включались в производственный процесс, в политическую работу, стремясь принести пользу развивающемуся на совершенно новых основах обществу. 3то в полной мере относилось и к корейскому этническому меньшинству. в зтой с т атье рассмотрены формы и методы работы Союза корейцев, поживающих на территории СССР в 1920гг . Страктypbl и главные фигуры Союз а тоже отмеченны .
The Grammaticalization of Demonstratives: A Comparative Analysis
Nicholas Catasso 세종대학교 언어연구소 2011 Journal of Universal Language Vol.12 No.1
An article, irrespective of its distribution across natural languages,dialects and varieties, is a member of the class of determiners which particularizes a noun according to language-specific principles of grammatical and semantic structuring. Definite articles in Indo-European languages – in those grammatical systems where they are present – are derived from ancient demonstratives through a grammaticalization process: given that demonstratives are deictic expressions (i.e. they depend on a frame of reference which is external to that of the speaker and of the interlocutor) with the role of selecting a referent or a set of referents, it is easy to understand what the role of “universal quantifier” of the, which is in English the prototypical – but questionable – example of definiteness, is due to. Demonstratives are frequently reanalyzed across languages as grammatical markers (very often as definite articles, but also as copulas, relative and third person pronouns, sentence connectives, focus markers, etc.). In this article I concentrate on the grammaticalization of the definite article in English, adopting a comparative-contrastive approach (including a wide range of Indo-European languages), given the complexity of the article.
Nicholas George Mowbray,Carven Chin,Patricia Duncan,David O’Reilly,Zsolt Kaposztas,Sameer Junnarkar,Nagappan Kumar 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.1
Backgrounds/Aims: As populations age, an increased incidence of colorectal cancer will generate an increase in colorectal cancer liver metastases (CRLM). In order to guide treatment decisions, this study aimed to identify the contemporary complication rates of elderly patients undergoing liver resection for CRLM in a, centralised, UK centre. Methods: All patients undergoing operative procedures for CRLM between January 2013 and January 2019 were included. Patient, tumour and operative data were analysed, including the prognostic marker; tumour burden score. Results: 339 operations were performed on 289 consecutive patients with CRLM (272 patients <75 years old, 67 patients ≥75 years old). Median age was 66 years (range 20-93). There was no difference in major complication rates between the two age cohorts (6.65 vs. 6.0%, p=0.847) or operative mortality (1.1% vs. 1.4%, p=0.794). Younger patients had higher R1 resection rates (20.4% vs. 4.5%, p=0.002) and post-operative chemotherapy rates (60.3% vs. 35.8%, p< 0.001). The 1, 3 and 5-year OS was 90.2%, 70.5% and 52.3% respectively, median 70 months, with no difference between age cohorts (p=0.772). Tumour Burden score and operation type were independent predictors of overall survival. Conclusions: Liver resection for CRLM in patients 75 years and older is feasible, safe and confers a similar 5-year survival rate to younger patients. The current outcomes from surgery are better than historical datasets.