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- 저자 : Ni Xiangdong (검색결과 2 건)
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Ni Heliang,Hu Xiangdong,Yang Nannan,Liu Xiaoyang,Cai Wenyang,Zhong Rui,Wang Tiancheng,Yu Mingxi,Tang Shuang 한국독성학회 2024 Toxicological Research Vol.40 No.3
Roundup, a glyphosate-based herbicide widely used in agriculture, has raised concerns regarding its potential impact on human health due to the detection of its residues in human urine and serum. Granulosa cells are essential for oocyte growth and follicle development. Previous research has shown that Roundup could affect steroid synthesis, increases oxidative stress, and induces apoptosis in granulosa cells. However, little is known about the effects of Roundup on NLRP3 (nucleotide binding oligomerization domain-like receptor family pyrin-containing domain protein 3) inflammasome activation and cellular senescence in granulosa cells. Here, we provided evidence that exposure to Roundup induced premature senescence in mouse granulosa cells through the activation of NLRP3 inflammasome triggered by mitochondrial ROS. Our findings demonstrated that Roundup significantly reduced the viability of granulosa cells under in vitro culture conditions. It also disrupted mitochondrial function and induced oxidative stress in these cells. Subsequent investigations showed that NLRP3 inflammasome was activated in treated granulosa cells, as evidenced by the upregulation of inflammasome-related genes and the processing of inflammatory cytokines IL-1β and IL-1α into their mature forms. Consequently, premature cellular senescence occurred in response to the challenge posed by Roundup. Notably, direct inhibition of NLRP3 inflammasome with MCC950 does not alleviate mitochondrial damage and oxidative stress. However, supplementation of resveratrol, which has been known to attenuate mitochondrial damage and oxidative stress, effectively mitigated the inflammatory response and the expression of senescence-related markers, and prevented the senescence in granulosa cells. These results suggested that mitochondrial function and oxidative homeostasis might play pivotal roles as upstream regulators of NLRP3 inflammasome. In summary, our findings indicated that the premature senescence of granulosa cells caused by mitochondrial ROS-triggered NLRP3 inflammasome activation might contribute to the ovarian toxicity of Roundup, in addition to its known effects on steroidogenesis and apoptosis.
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MAXIMUM CORRENTROPY EXTENDED KALMAN FILTER FOR VEHICLE STATE OBSERVATION
Qi Dengliang,Feng Jingan,Ni Xiangdong,Wang Lei 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.2
For vehicle state estimation, the conventional Kalman filter performs well under the Gaussian assumption, but in the real non-Gaussian situation (especially when the noise is non-Gaussian heavy-tailed), it shows poor accuracy and robustness. In this paper, an extended Kalman filter (EKF) algorithm based on the maximum correntropy criterion (MCC) is proposed (MCCEKF), and a lateral-longitudinal coupled vehicle model is established, while a state observer containing the yaw rate, vehicle sideslip angle, and longitudinal vehicle speed is designed using the easily available measurement information of on-board sensors. After analyzing the complexity of the proposed algorithm, the new algorithm is verified on the Simulink/CarSim simulation experimental platform by Double Lane Change and Sine Sweep Steer Torque Input maneuver. Experimental results show that the MCC-based EKF algorithm has stronger robustness and better estimation accuracy than the traditional EKF algorithm in the case of non-Gaussian noise, and the MCCEKF is more applicable for vehicle state estimation in practical situations.
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