The effective model of the human Acetyl-CoA Carboxylase inhibition by aromatic-structure inhibitors

Nguyen Truong Cong Minh,Bui Tho Thanh,Le Xuan Truong,Nguyen Thi Bang Suong,Le Thi Xuan Thao 한국전기전자학회 2017 전기전자학회논문지 Vol.21 No.3

The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor (IC50) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology – Jadavpur University – India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.

The effective model of the human Acetyl-CoA Carboxylase inhibition by aromatic-structure inhibitors

Minh, Nguyen Truong Cong,Thanh, Bui Tho,Truong, Le Xuan,Suong, Nguyen Thi Bang,Thao, Le Thi Xuan Institute of Korean Electrical and Electronics Eng 2017 전기전자학회논문지 Vol.21 No.3

The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor ($IC_{50}$) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology - Jadavpur University - India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.

A novel control method to maximize the energy-harvesting capability of an adjustable slope angle wave energy converter

Tri, Nguyen Minh,Truong, Dinh Quang,Thinh, Do Hoang,Binh, Phan Cong,Dung, Dang Tri,Lee, Seyoung,Park, Hyung Gyu,Ahn, Kyoung Kwan Elsevier 2016 RENEWABLE ENERGY Vol.97 No.-

<P><B>Abstract</B></P> <P>This paper introduces a novel control approach to maximizing the output energy of an adjustable slope angle wave energy converter (ASAWEC) with oil-hydraulic power take-off. Different from typical floating-buoy WECs, the ASAWEC is capable of capturing wave energy from both heave and surge modes of wave motions. For different waves, online determination of the titling angle plays a significant role in optimizing the overall efficiency of the ASAWEC. To enhance this task, the proposed method was developed based on a learning vector quantitative neural network (LVQNN) algorithm. First, the LVQNN-based supervisor controller detects wave conditions and directly produces the optimal titling angles. Second, a so-called efficiency optimization mechanism (EOM) with a secondary controller was designed to regulate automatically the ASAWEC slope angle to the desired value sent from the supervisor controller. A prototype of the ASAWEC was fabricated and a series of simulations and experiments was performed to train the supervisor controller and validate the effectiveness of the proposed control approach with regular waves. The results indicated that the system could reach the optimal angle within 2s and subsequently, the output energy could be maximized. Compared to the performance of a system with a vertically fixed slope angle, an increase of 5% in the overall efficiency was achieved. In addition, simulations of the controlled system were performed with irregular waves to confirm the applicability of the proposed approach in practice.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper proposes a novel energy maximization algorithm of a sliding-buoy wave energy converter (SBWEC). </LI> <LI> An efficiency optimization mechanism is designed and integrated into the SBWEC. </LI> <LI> The control logic is based on a learning vector quantitative neural network for classifying the wave information. </LI> <LI> The effectiveness of the proposed approach is verified through both simulations and experiments. </LI> </UL> </P>

A study on modeling of a hybrid wind wave energy converter system

Tri Dung Dang,Cong Binh Phan,Hoai Vu Anh Truong,Chau Duy Le,Minh Tri Nguyen,Kyoung-Kwan Ahn 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10

A model of a hybrid wind wave energy converter (HWWEC) system is proposed in this paper. The HWWEC includes two wave buoys and a vertical axis wind turbine (VAWT) system, which co-works to drive a generator. Wave buoys are arranged in an arc pattern to capture efficiently wave energy from many directions. The hydrodynamic forces are calculated by the Wave Analysis at Massachusetts Institute of Technology WAMIT software. In order to bring the system into resonance with the incident wave frequencies, a variable inertia hydraulic flywheel is employed so that the power output is maximized. Specifications and working principle of the whole system are presented and described. WEC unit model and hybrid mechanism are also presented. Simulations are carried out to evaluate the performance the HWWEC with the given specifications. Then, simulation results under some phase differences are taken to investigate the influence on the overall efficiency.

Aerodynamic drag of axisymmetric models with different boattail angles under subsonic and supersonic flow conditions

The Hung Tran,Cong Truong Dao,Dinh Anh Le,Van Khiem Pham,Van Minh Do,Trang Minh Nguyen 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12

This study examines the drag trend and flow behavior of axisymmetric models with conical boattails under subsonic and supersonic conditions by using a numerical approach. Mach numbers ranging from 0.1 to 3.0 and boattail angles varying from 0° to 24° are investigated. The numerical results are validated by experimental data under identical flow conditions. The flow behavior around the boattail body, the total drag, and the pressure distribution are analyzed in detail. The drag components acting on the boattail surface are examined to determine the reason for the change in drag due to different boattail angles and Mach number conditions. Results show that the minimum drag is around 14° for subsonic flow, but this value suddenly decreases to around 7° for supersonic flow. Formalization of the expansion and oblique shocks on the boattail is the main cause of changes in the pressure distribution on the surfaces, which in turn affect the drag trend. Moreover, the relationships among boattail angle, flow conditions, and four flow types on the boattail surface are presented in detail.

Modeling and Energy Management Strategy in Energetic Macroscopic Representation for a Fuel Cell Hybrid Electric Vehicle

TOXUAN DINH,Le Khac Thuy,Nguyen Thanh Tien,Tri Dung Dang,Cong Minh Ho,Hoai Vu Anh Truong,Hoang Vu Dao,Tri Cuong Do,안경관 사단법인 유공압건설기계학회 2019 드라이브·컨트롤 Vol.16 No.2

Fuel cell hybrid electric vehicle is an attractive solution to reduce pollutants, such as noise and carbon dioxide emission. This study presents an approach for energy management and control algorithm based on energetic macroscopic representation for a fuel cell hybrid electric vehicle that is powered by proton exchange membrane fuel cell, battery and supercapacitor. First, the detailed model of the fuel cell hybrid electric vehicle, including fuel cell, battery, supercapacitor, DC-DC converters and powertrain system, are built on the energetic macroscopic representation. Next, the power management strategy was applied to manage the energy among the three power sources. Moreover, the control scheme that was based on back-stepping sliding mode control and inversed-model control techniques were deduced. Simulation tests that used a worldwide harmonized light vehicle test procedure standard driving cycle showed the effectiveness of the proposed control method.

Modeling and Energy Management Strategy in Energetic Macroscopic Representation for a Fuel Cell Hybrid Electric Vehicle

Dinh, To Xuan,Thuy, Le Khac,Tien, Nguyen Thanh,Dang, Tri Dung,Ho, Cong Minh,Truong, Hoai Vu Anh,Dao, Hoang Vu,Do, Tri Cuong,Ahn, Kyoung Kwan The Korean Society for Fluid Power and Constructio 2019 드라이브·컨트롤 Vol.16 No.2

Fuel cell hybrid electric vehicle is an attractive solution to reduce pollutants, such as noise and carbon dioxide emission. This study presents an approach for energy management and control algorithm based on energetic macroscopic representation for a fuel cell hybrid electric vehicle that is powered by proton exchange membrane fuel cell, battery and supercapacitor. First, the detailed model of the fuel cell hybrid electric vehicle, including fuel cell, battery, supercapacitor, DC-DC converters and powertrain system, are built on the energetic macroscopic representation. Next, the power management strategy was applied to manage the energy among the three power sources. Moreover, the control scheme that was based on back-stepping sliding mode control and inversed-model control techniques were deduced. Simulation tests that used a worldwide harmonized light vehicle test procedure standard driving cycle showed the effectiveness of the proposed control method.

Effects of non-vertical linear motions of a hemispherical-float wave energy converter

Do, Hoang-Thinh,Dinh, Quang-Truong,Nguyen, Minh-Tri,Phan, Cong-Binh,Dang, Tri-Dung,Lee, Seyoung,Park, Hyung-Gyu,Ahn, Kyoung-Kwan Elsevier 2015 Ocean engineering Vol.109 No.-

<P><B>Abstract</B></P> <P>The hydraulic power-take-off mechanism (HPTO) is one of the most popular methods in wave energy converter (WECs). However, the conventional HPTO with only one direction motion has some drawbacks which limit its power capture capability. This paper proposes an <I>adjustable slope angle wave energy converter</I> (ASAWEC) and investigates the effect of slope angle on the performance of the proposed wave energy converter to find the optimal slope angle with the purpose to increase the power capture capability as well as energy efficiency. A mathematical model of components from a floating buoy to a hydraulic motor was modeled. A small scale WEC test rig was fabricated to verify the power capture capability and efficiency of the proposed system throughout experiments.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper proposed an adjustable moving angle wave energy converter (AMAWEC). </LI> <LI> Mathematical model of AMAWEC was presented and simulated. </LI> <LI> An AMAWEC test rig were fabricated to do the experiment in variety of wave conditions and moving angle in the water tank. </LI> <LI> The effect of moving angle on the performance of a wave energy converter was investigated to find the optimal moving angle in each wave condition. </LI> <LI> Finally, the effectiveness of AMAWEC has been verified by experimental results. </LI> </UL> </P>